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【drug-news】求助：关于二型糖尿病文摘的翻译

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这个帖子发布于12年零262天前，其中的信息可能已发生改变或有所发展。

我在翻译以下关于二型糖尿病的文摘中遇到了难题，急求大家帮助解决，谢谢啊！

Our collective knowledge base of pathways and discrete proteins that contribute to distinctive pathophysiological traits underlying the metabolic syndrome and type 2 diabetes is expanding rapidly. This momentum is fuelled by the quantum leap in potential ‘players’ provided by the annotated human genome sequence databases and molecular techniques such as DNA microarrays and gene knockouts, and the identification of potential disease genes in humans and model species. The examples of recently discovered drug targets described above strongly suggest that this increase in newly identified components of disease susceptibility will yield an even wider array of potential approaches for therapeutic intervention. In addition to small-molecule modulators of ‘classical’ receptor or enzyme targets, research could identify additional protein therapeutics, such as GLP-1 analogues, and even more novel approaches, such as antisense oligonucleotide-based therapies.
我们对于途径和个别蛋白这些导致代谢综合症和Ⅱ型糖尿病的潜在并立生理学特征的知识库正迅速扩充。人类基因序列库和诸如DNA微数列和基因敲除的分子技术使得这一领域大步向前迈进，人类和疾病模型中的潜在的疾病基因也将得到识别。以上谈到的最近新发现的药物靶点的例子将给我们为疾病易感性坚定组分带来更广泛的潜在治疗干预途径。除了经典受体或酶靶点的小分子调节剂，我们的研究也将鉴定出其他的蛋白治疗方法，例如GLP-1分析以及甚至更多的新颖的途径，如基于反义寡核苷酸的治疗。

Intensive study of the mechanisms of action of older drugs has provided further validation of several recently identified drug targets. Further efforts in this direction are likely to be fruitful. Given the multifactorial nature of the genetic and environmental factors that contribute to the genesis of metabolic syndrome and type 2 diabetes, it is probable that further efforts to characterize disease ‘sub-phenotypes’ and specific genetic markers will translate into more selective therapies tailor-made for distinct subgroups of patients or those at risk of developing disease. These individuals may be identified on the basis of specific genotypes or more specific clinical markers of distinct physiological derangements.
对老药作用机制的广泛的研究将为新近发现的药物靶点提供更多的证据。这一方向的进一步研究将是硕果累累。假定导致代谢综合症和Ⅱ型糖尿病发病的基因和环境因素的多因子本质得以阐述，很可能对于鉴定疾病“亚表观型”和特异性遗传标记的工作将带来不同亚群病人或者处于疾病发展途中的人们更多选择性治疗途径。这些个人可能基于特异性基因型或者更多特异性不同生理学紊乱的临床标记。

谢谢大家了啊！

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