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【medical-news】长期使用非甾体类抗炎药可降低Alzheimer风险

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Ibuprofen May Cut Alzheimer's Risk

Study Shows Use of Ibuprofen for 5 Years Lowers Chances of Getting Alzheimer's

May 5, 2008 -- The long-term use of ibuprofen and possibly other nonsteroidal anti-inflammatory pain relievers may help protect against Alzheimer's disease, but it is still not clear if the risks outweigh the potential benefits.

Use of ibuprofen pain relievers like Advil and Motrin for more than five years reduced Alzheimer's risk by 44% in a study reported in the May issue of Neurology.

Long-term users of several other types of nonsteroidal anti-inflammatory drugs (NSAIDs) also had a lower than expected risk of Alzheimer's.

Ibuprofen users seemed to derive the most protection after five years of use, but researcher Steven C. Vlad, MD, of Boston University School of Medicine, says it is far too soon to recommend the use of this or any other NSAID to lower Alzheimer's risk.

"I would not advise patients to start taking an NSAID to prevent Alzheimer's," Vlad tells WebMD. "There are too many known risks associated with this class of medications, and we would need a lot more research to figure out the risk-benefit ratio."

(Have a family history of Alzheimer's and worried about yourself? Tell us how you're fighting back on WebMD's Alzheimer's Disease Support Group.)

NSAIDs and Alzheimer's
Researchers have long sought to prove that NSAIDs prevent or delay Alzheimer's by reducing the inflammation that is thought to play a major role in the disease.

But the investigations have been contradictory, with some suggesting a protective benefit for NSAID use and others showing no benefit.

In the newly published study, Vlad and colleagues examined the prescription records of more than 49,000 U.S. veterans with Alzheimer's and almost 197,000 age-matched veterans without the disease.

The average age of the people included in the study was 74; 97% were male.

Overall, the regular use of nonsteroidal pain relievers for more than five years was associated with a 24% reduction in the risk of Alzheimer's disease.

Use for less than five years was not as protective, and some of the pain relievers did not appear to be protective at all.

The Cox-2 inhibitors Celebrex and Vioxx showed no evidence of benefit. Vioxx is no longer available in the U.S.

"In our study ibuprofen was protective, but the Cox-2s weren't," he says. "For some of the other drugs we looked at, it wasn't really clear."

Risks vs. Benefits
Longtime Alzheimer's researcher David A. Bennett, MD, of Chicago's Rush University calls the findings "one more piece of evidence" suggesting that at least some NSAIDs help protect against Alzheimer's.

But he adds that more study is needed to confirm the findings and determine if the benefits of long-term use outweigh the potential harm.

Regular, long-term use of NSAIDs is associated with an increased risk of ulcers and potentially life-threatening stomach bleeding, especially in people over the age of 65.

Bennett directs the Rush Alzheimer's Disease Center and is a professor of neurological sciences.

"I would not prescribe ibuprofen or any NSAID based on the current data," Bennett tells WebMD. "In addition to the safety issues, we really don't know when NSAIDs would have to be used to see this benefit. There are just too many unanswered questions."

http://www.webmd.com/alzheimers/news/20080505/ibuprofen-may-cut-alzheimers-risk

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2008-05-06 16:53 浏览 : 2118 回复 : 5

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• 突发！传闻浙一有人投炸弹了，4人受伤

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2008-05-06 22:59

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• 医院试工害怕被「白嫖」怎么办？究竟去还是不去？

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Ibuprofen May Cut Alzheimer's Risk
布洛芬可能会降低阿尔茨海默氏症的风险
Study Shows Use of Ibuprofen for 5 Years Lowers Chances of Getting Alzheimer's
研究显示使用布洛芬5年可降低患阿尔茨海默氏症的风险
May 5, 2008 -- The long-term use of ibuprofen and possibly other nonsteroidal anti-inflammatory pain relievers may help protect against Alzheimer's disease, but it is still not clear if the risks outweigh the potential benefits.
2008年5月5日-长期使用布洛芬和其他抗炎解热镇痛药可能有助于防止老年痴呆症，但仍不明确其风险是否大于潜在的好处。
Use of ibuprofen pain relievers like Advil and Motrin for more than five years reduced Alzheimer's risk by 44% in a study reported in the May issue of Neurology.
5月Neurology中的一项研究报告指出，服用布洛芬解热镇痛药如Advil和Motrin， 5年以上可降低患老年痴呆症的风险44 ％。
Long-term users of several other types of nonsteroidal anti-inflammatory drugs (NSAIDs) also had a lower than expected risk of Alzheimer's.
长期服用其他几类非甾体抗炎药也可降低较预期的阿尔茨海默氏症风险。
Ibuprofen users seemed to derive the most protection after five years of use, but researcher Steven C. Vlad, MD, of Boston University School of Medicine, says it is far too soon to recommend the use of this or any other NSAID to lower Alzheimer's risk.
服用布洛芬五年者似乎效果最好，但研究者波士顿大学医学院的Steven C. Vlad博士，指出推荐使用这种或其他非甾体抗炎药以降低老年痴呆症的风险，目前为止还为时过早。
"I would not advise patients to start taking an NSAID to prevent Alzheimer's," Vlad tells WebMD. "There are too many known risks associated with this class of medications, and we would need a lot more research to figure out the risk-benefit ratio."
“我不会建议病人开始采取非甾体抗炎药以预防阿尔茨海默氏症， ” Vlad向WebMD表示。 “有太多的已知风险与此类药物相关，我们将需要进一步的研究，以指出的风险-效益比” 。
(Have a family history of Alzheimer's and worried about yourself? Tell us how you're fighting back on WebMD's Alzheimer's Disease Support Group.)
（您会担心自己的阿尔茨海默氏症家族病史吗？请告诉我们，您是如何对抗webmd的阿尔茨海默病支持小组的）。
NSAIDs and Alzheimer's
Researchers have long sought to prove that NSAIDs prevent or delay Alzheimer's by reducing the inflammation that is thought to play a major role in the disease.
非甾体抗炎药和阿尔茨海默氏症
研究人员很早就试图证明非甾体抗炎药通过减少在阿尔茨海默氏症中发挥了重要作用的炎症可防止或延缓这种疾病。
But the investigations have been contradictory, with some suggesting a protective benefit for NSAID use and others showing no benefit.
但调查结果一直存在矛盾，有些提示使用非甾体抗炎药有利于预防但其他显示没有任何好处。
In the newly published study, Vlad and colleagues examined the prescription records of more than 49,000 U.S. veterans with Alzheimer's and almost 197,000 age-matched veterans without the disease.
在新出版的研究中，Vlad和同事研究了超过4.9万患阿尔茨海默氏症的美国退伍军人和近197000例年龄配伍的无此疾患的退伍军人的处方纪录。
The average age of the people included in the study was 74; 97% were male.
研究对象的平均年龄为74岁，其中97 ％为男性。
Overall, the regular use of nonsteroidal pain relievers for more than five years was associatedwith a 24% reduction in the risk of Alzheimer's disease.
整体来说，规律副用非甾体抗炎药5年以上者可降低24 ％的阿尔茨海默病风险。
Use for less than five years was not as protective, and some of the pain relievers did not appear to be protective at all.
使用不足五年者不具有预防作用，并且有些镇痛药缺乏似乎缺乏预防作用。
The Cox-2 inhibitors Celebrex and Vioxx showed no evidence of benefit. Vioxx is no longer available in the U.S.
没有证据显示Cox-2抑制剂Celebrex和Vioxx具有益处。 Vioxx已不再在美国使用。
"In our study ibuprofen was protective, but the Cox-2s weren't," he says. "For some of the other drugs we looked at, it wasn't really clear."
“在我们的研究中布洛芬具有预防作用，但Cox-2类没有， ”他说。 “其他一些药物的作用目前尚不清楚” 。
Risks vs. Benefits
Longtime Alzheimer's researcher David A. Bennett, MD, of Chicago's Rush University calls the findings "one more piece of evidence" suggesting that at least some NSAIDs help protect against Alzheimer's.
风险与好处
长期从事老年痴呆症研究芝加哥Rush大学的David A. Bennett博士，回应这一结论， “又一项证据”表明至少某些非甾体抗炎药有助于防止老年痴呆症。
But he adds that more study is needed to confirm the findings and determine if the benefits of long-term use outweigh the potential harm.
但他补充说，还需要进行更多的研究来确认结果，并确定长期使用所带来的好处是否大于潜在的危害。
Regular, long-term use of NSAIDs is associated with an increased risk of ulcers and potentially life-threatening stomach bleeding, especially in people over the age of 65.
规律，长期使用非甾体抗炎药增加了溃疡和潜在可危及生命的胃出血的相关风险，特别是超过65岁者。
Bennett directs the Rush Alzheimer's Disease Center and is a professor of neurological sciences.
Bennett作为一名神经科学专家并领导着Rush的阿尔茨海默病中心。
"I would not prescribe ibuprofen or any NSAID based on the current data," Bennett tells WebMD. "In addition to the safety issues, we really don't know when NSAIDs would have to be used to see this benefit. There are just too many unanswered questions."
“基于目前的资料，我不会处方布洛芬或任何非甾体抗炎药 ” Bennett向WebMD表示。 “除了安全问题，我们还不清楚，使用非甾体抗炎药是否有益处。有太多悬而未决的问题” 。

2008-05-07 00:13

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• 浙一咋了？？爆炸了？？？

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布洛芬可能会降低阿尔茨海默氏症的风险
研究显示使用布洛芬5年可降低患阿尔茨海默氏症的风险
2008年5月5日-长期使用布洛芬和其他抗炎解热镇痛药可能有助于防止老年痴呆症，但仍不明确其风险是否大于潜在的好处。
5月Neurology中的一项研究报告指出，服用布洛芬解热镇痛药如Advil和Motrin， 5年以上可降低患老年痴呆症的风险44 ％。长期服用其他几类非甾体抗炎药也可降低较预期的阿尔茨海默氏症风险。服用布洛芬五年者似乎效果最好，但研究者波士顿大学医学院的Steven C. Vlad博士，指出推荐使用这种或其他非甾体抗炎药以降低老年痴呆症的风险，目前为止还为时过早。“我不会建议病人开始采取非甾体抗炎药以预防阿尔茨海默氏症， ” Vlad向WebMD表示。 “有太多的已知风险与此类药物相关，我们将需要进一步的研究，以指出的风险-效益比” 。
（您会担心自己的阿尔茨海默氏症家族病史吗？请告诉我们，您是如何对抗webmd的阿尔茨海默病支持小组的）。
非甾体抗炎药和阿尔茨海默氏症
研究人员很早就试图证明非甾体抗炎药通过减少在阿尔茨海默氏症中发挥了重要作用的炎症可防止或延缓这种疾病。但调查结果一直存在矛盾，有些提示使用非甾体抗炎药有利于预防但其他显示没有任何好处。在新出版的研究中，Vlad和同事研究了超过4.9万患阿尔茨海默氏症的美国退伍军人和近197000例年龄配伍的无此疾患的退伍军人的处方纪录。研究对象的平均年龄为74岁，其中97 ％为男性。整体来说，规律副用非甾体抗炎药5年以上者可降低24 ％的阿尔茨海默病风险。使用不足五年者不具有预防作用，并且有些镇痛药缺乏似乎缺乏预防作用。没有证据显示Cox-2抑制剂Celebrex和Vioxx具有益处。 Vioxx已不再在美国使用。“在我们的研究中布洛芬具有预防作用，但Cox-2类没有， ”他说。 “其他一些药物的作用目前尚不清楚” 。
风险与好处
长期从事老年痴呆症研究芝加哥Rush大学的David A. Bennett博士，回应这一结论， “又一项证据”表明至少某些非甾体抗炎药有助于防止老年痴呆症。但他补充说，还需要进行更多的研究来确认结果，并确定长期使用所带来的好处是否大于潜在的危害。规律，长期使用非甾体抗炎药增加了溃疡和潜在可危及生命的胃出血的相关风险，特别是超过65岁者。
Bennett作为一名神经科学专家并领导着Rush的阿尔茨海默病中心。
“基于目前的资料，我不会处方布洛芬或任何非甾体抗炎药 ” Bennett向WebMD表示。 “除了安全问题，我们还不清楚，使用非甾体抗炎药是否有益处。有太多悬而未决的问题” 。

2008-05-07 00:17

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