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【medical-news】一种检测乳腺癌的新仪器

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Breast Cancer Detection: A Simpler Alternative To Mammograms?

Whether a painless, portable device that uses electrical current rather than X-ray to look for breast cancer could be an alternative to traditional mammograms is under study at the Medical College of Georgia.
MCG is one of 20 centers internationally and the only place in Georgia studying new technology developed by Z-Tech Inc., to compare traditional mammograms with impedence scanning, a technique based on evidence that electrical current passes through cancerous tissue differently than through normal tissue.
This phase of the study will focus on women age 40-50. Older women have less dense breast tissue so cancer is easier to find, says Dr. James Craft, MCG radiologist and principal investigator on the study. Mammograms, also performed in the study, are more accurate in this population, so this phase will be a tougher test of the new technology, he says. The first phase of the study, which began in 2005, was open to women of all ages.
“Normal breast tissue is very dense, especially in younger women, and can hide tumors,” Dr. Craft says. “While we’ve known for a while that water flows more freely through cancerous cells, we also know that electrical current flows easier through cancerous and tumor tissue.”
The Z-Tech scan works by placing a flower-shaped grouping of electrodes over each breast and sending a small, painless amount of electricity through them. Unlike traditional mammography, the scan does not involve breast compression or radiation.
“It’s like doing an EKG of the breast,” Dr. Craft says.
A computer immediately calculates and presents a report based on the electrical signature of the breast tissue. Rather than waiting on breast image from a traditional mammogram, the computer immediately notes whether the scan is positive or negative for cancer.
However, for study purposes, neither Dr. Craft nor the patient will know the results. Patients must undergo a mammogram within 90 days, which Dr. Craft interprets. Z-Tech compares those results to the electrical study.
The hope is that the new test – called HEDA for Homologous Electrical Difference Analysis – will provide an alternative to mammograms. While Dr. Craft believes that having this test should help find more cancers, he doesn’t think it will replace traditional mammography.
“This method doesn’t use radiation, is portable and there is no pain associated with the squeezing that mammograms require,” he says. “I can see it being used as an additional test. I don’t think it will replace mammography, but it could increase our chances of catching breast cancer.”
The second phase of the Z-Tech trial is open to women age 40-50 having routine mammograms as well as those who have a suspicious lump scheduled for biopsy.
http://www.sciencedaily.com/releases/2008/07/080722113019.htm

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2008-07-27 10:41 浏览 : 685 回复 : 3

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frozenme

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2008-07-27 21:18

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Breast Cancer Detection: A Simpler Alternative To Mammograms?
乳腺癌检测：一种检测乳腺癌的新仪器？
Whether a painless, portable device that uses electrical current rather than X-ray to look for breast cancer could be an alternative to traditional mammograms is under study at the Medical College of Georgia.
乔治亚州立大学医学院正在进行一项改变传统乳腺影像学检测方法的研究：是否能用一种无痛的易携带的电流仪器来代替现在X射线的方法来检测乳腺癌。
MCG is one of 20 centers internationally and the only place in Georgia studying new technology developed by Z-Tech Inc., to compare traditional mammograms with impedence scanning, a technique based on evidence that electrical current passes through cancerous tissue differently than through normal tissue.
乔治亚州立大学医学院（MCG）由Z-Tech有限公司在世界上设立的开发新技术项目的20个中心之一，也是乔治亚州唯一的研究中心。与传统应用阻抗扫描的影像学检查相比，一项新的技术可以利用电流通过肿瘤组织与正常组织的不同来检测肿瘤。
This phase of the study will focus on women age 40-50. Older women have less dense breast tissue so cancer is easier to find, says Dr. James Craft, MCG radiologist and principal investigator on the study. Mammograms, also performed in the study, are more accurate in this population, so this phase will be a tougher test of the new technology, he says. The first phase of the study, which began in 2005, was open to women of all ages.
乔治亚州立大学医学院的放射学家同时兼任本项研究的主要研究者Dr. James Craft说：“现阶段的研究主要集中在年龄40-50岁的妇女。因为年龄较大的妇女乳腺组织密度低，所以肿瘤比较容易发现。研究也包括乳腺的影像学检查，在这部份人群中影像学检查在诊断上表现得更为准确，因而这项新技术在现阶段测验更有难度。
“Normal breast tissue is very dense, especially in younger women, and can hide tumors,” Dr. Craft says. “While we’ve known for a while that water flows more freely through cancerous cells, we also know that electrical current flows easier through cancerous and tumor tissue.”
“正常乳腺组织密度比较高，尤其是年轻女性，这种情况下可能会掩盖肿瘤，”Dr Craft说，“而我们已经知道水流通过肿瘤细胞比较容易，而电流通过肿瘤细胞和肿瘤组织也比较容易。”
The Z-Tech scan works by placing a flower-shaped grouping of electrodes over each breast and sending a small, painless amount of electricity through them. Unlike traditional mammography, the scan does not involve breast compression or radiation.
Z-Tech扫描仪通过将一组花形的电极置于每一个乳房上，并释放一组很小的无痛剂量的电流通过乳房。不像传统的乳腺影像学检查那样，这种扫描仪检查不需要压缩乳房或者射线辐射。
“It’s like doing an EKG of the breast,” Dr. Craft says.
Dr. Craft说：“就像是给乳房做心电图一样。”
A computer immediately calculates and presents a report based on the electrical signature of the breast tissue. Rather than waiting on breast image from a traditional mammogram, the computer immediately notes whether the scan is positive or negative for cancer.
电脑很快就能计算出结果并提供一个关于乳腺组织电流特征的报告。这种检查不需要象传统的乳腺影像学检查那样去等待乳房影像，电脑即刻就可以给出这次肿瘤扫描是阳性或者是阴性的结果。
However, for study purposes, neither Dr. Craft nor the patient will know the results. Patients must undergo a mammogram within 90 days, which Dr. Craft interprets. Z-Tech compares those results to the electrical study.
然而，基于研究本身的目的，Dr. Craft和参与研究的病人都不知道检查的结果。DR. Craft解释说：“病人在90天内必须接受乳腺影像学检查，而Z-Tech公司会将影像学检查的结果与电流学研究的结果作比较分析。”
The hope is that the new test – called HEDA for Homologous Electrical Difference Analysis – will provide an alternative to mammograms. While Dr. Craft believes that having this test should help find more cancers, he doesn’t think it will replace traditional mammography.
新的方法———同源染色体电流区别分析法（HEDA）将会给乳腺影像学检查方法的改进带来希望。Dr. Craft相信通过这种检测有利于发现更多的肿瘤，但是他认为这并不能替代传统的乳腺影像学检查。
“This method doesn’t use radiation, is portable and there is no pain associated with the squeezing that mammograms require,” he says. “I can see it being used as an additional test. I don’t think it will replace mammography, but it could increase our chances of catching breast cancer.”
他还指出：“这种方法不需要使用射线，具有便携性，而且没有乳腺影像学检查时要求的挤压带来的疼痛感，我能想象到它能成为一种辅助检查方法，但它并不能完全替代乳腺的影像学检查，但是它能增加我们发现乳腺癌的机会。”
The second phase of the Z-Tech trial is open to women age 40-50 having routine mammograms as well as those who have a suspicious lump scheduled for biopsy.
第二阶段的Z-Tech试验的对象包括年龄在40-50岁的接受过常规乳腺影像学检查的妇女以及那些患有乳腺包块等待常规病理切片的妇女。

编译：

乳腺癌检测：一种检测乳腺癌的新仪器？

乔治亚州立大学医学院正在进行一项改变传统乳腺影像学检测方法的研究：是否能用一种无痛的易携带的电流仪器来代替现在X射线的方法来检测乳腺癌。
乔治亚州立大学医学院的放射学家同时兼任本项研究的主要研究者---Dr. James Craft说：“现阶段的研究主要集中在年龄40-50岁的妇女。因为年龄较大的妇女乳腺组织密度低，所以肿瘤比较容易发现。研究也包括乳腺的影像学检查，在这部份人群中影像学检查在诊断上表现得更为准确，因而这项新技术在现阶段测验更有难度。
“正常乳腺组织密度比较高，尤其是年轻女性，这种情况下可能会掩盖肿瘤的表现，”Dr Craft说，“而我们已经知道水流通过肿瘤细胞比较容易，而电流通过肿瘤细胞和肿瘤组织也比较容易。” Z-Tech扫描仪通过将一组花形的电极置于每一个乳房上，并释放一组很小的无痛剂量的电流通过乳房。不像传统的乳腺影像学检查那样，这种扫描仪检查不需要压缩乳房或者射线辐射。Dr. Craft说：“就像是给乳房做心电图一样。”电脑很快就能计算出结果并提供一个关于乳腺组织电流特征的报告。这种检查不需要象传统的乳腺影像学检查那样去等待乳房影像，电脑即刻就可以给出这次肿瘤扫描是阳性或者是阴性的结果。
然而，基于研究本身的目的，Dr. Craft和参与研究的病人都不知道检测的结果。DR. Craft解释说：“病人在90天内必须接受乳腺影像学检查，而Z-Tech公司会将影像学检查的结果与电流学研究的结果作比较分析。”
新的方法---同源染色体电流区别分析法（HEDA）将会给从传统乳腺影像学检查方法的改进带来希望。Dr. Craft相信通过这种检测将有利于发现更多的肿瘤，但是他认为这并不能替代传统的乳腺影像学检查。他指出：“这种方法不需要使用射线，具有便携性，而且没有那种象乳腺影像学检查时所要求的挤压而带来的疼痛感，我能想象到它将能成为一种有用的辅助检查方法，但是它并不能完全替代乳腺的影像学检查，不过它的确能够增加我们发现乳腺癌的机会。”
第二阶段的Z-Tech试验的对象包括年龄在40-50岁的接受过常规乳腺影像学检查的妇女以及那些患有乳腺包块等待常规病理切片的妇女。

2008-07-28 21:03

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xunan2005

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frozenme战友翻译的已经很好，吹毛求疵一下

“This method doesn’t use radiation, is portable and there is no pain associated with the squeezing that mammograms require,” he says. “I can see it being used as an additional test. I don’t think it will replace mammography, but it could increase our chances of catching breast cancer.”
他还指出：“这种方法不需要使用射线，具有便携性，而且没有乳腺影像学检查时要求的挤压带来的疼痛感，我能想象到它能成为一种辅助检查方法，但它并不能完全替代乳腺的影像学检查，但是它能增加我们发现乳腺癌的机会。”
这种检测技术不需使用射线，具有便携性，而且不会像乳腺X线射影那样检查需要挤压而产生疼痛

The second phase of the Z-Tech trial is open to women age 40-50 having routine mammograms as well as those who have a suspicious lump scheduled for biopsy.
第二阶段的Z-Tech试验的对象包括年龄在40-50岁的接受过常规乳腺影像学检查的妇女以及那些患有乳腺包块等待常规病理切片的妇女。
...以及发现可疑肿块拟行活检的女性

另外，我对这篇文章所介绍内容的一点看法：
这项技术的原理是利用血流的差异造成电阻的不同，从而产生导出电流信号的差异，1.具体的评价标准是怎样？2.检测结果的表述是怎样，图形还是数字？会不会比较抽象不如B超、X线直观？3.不同病人乳腺组织密度不同，含“水”量不同（年轻、哺乳期、老年），同一病人不同部位乳腺组织厚度不同，这些因素造成的电流传导差异怎样校正？
不知道这项技术的性价比怎么样，如果效果像乳腺红外线那样，到头来还是需要依靠B超、X线来帮助诊断，徒增患者经济负担，恐怕它的临床应用前景不会很好。

2008-07-29 18:32

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xunan2005 编辑于 2008-07-30 00:37

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