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【medical-news】有关先兆子痫的研究取得重要进展

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Research on pre-eclampsia in mice may have important implications for humans

Published: Sunday, 27-Jul-2008

In a new March of Dimes-funded study of pre-eclampsia, a serious and potentially deadly disorder that affects about 5 percent of pregnancies, researchers have found results in mice that may have important implications for diagnosis and treatment in humans.
Yang Xia, M.D., Ph.D., and Rodney E. Kellems, Ph.D., Department of Biochemistry and Molecular Biology; and Susan M. Ramin, M.D., Department of Obstetrics, Gynecology and Reproductive Science, all at the University of Texas-Houston Medical School, and colleagues report today in the journal Nature Medicine that they induced pre-eclampsia in mice by injecting them with certain human autoantibodies that have been found in women with pre-eclampsia. The mice showed multiple features of the disorder, including dangerously high blood pressure, protein in the urine, and placental abnormalities. Then the researchers gave the mice a substance that blocks the action of the autoantibodies; this prevented the development of pre-eclampsia.

The investigators say they demonstrated an important pathway of pre-eclampsia as well as a potential new approach to diagnosis and treatment.

Pre-eclampsia may require pre-term delivery (birth before 37 completed weeks gestation) to prevent severe complications to mother and baby, because delivery is the only cure for the disorder.

Preterm birth is a serious and costly health problem and the leading cause of death in the first month of life. More than a half million babies - one out of every eight - are born too soon each year in the United States. Babies who survive face the risk of serious life-long health problems including learning disabilities, cerebral palsy, blindness, hearing loss, and other chronic conditions including asthma. Even infants born just a few weeks too soon have a greater risk of breathing problems, feeding difficulties, temperature instability (hypothermia), jaundice and delayed brain development.

The March of Dimes also is helping to support a large World Health Organization study to evaluate whether a new screening test is in fact a reliable predictor of the development of pre-eclampsia, as well as the feasibility of doing testing in developing nations where pre-eclampsia causes a significant number of deaths among pregnant women and babies.

http://www.marchofdimes.com/

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2008-07-28 21:53 浏览 : 816 回复 : 5

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2008-07-28 22:57

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先兆子痫的动物研究取得重要进展（2008年7月27日最新消息）
In a new March of Dimes-funded study of pre-eclampsia, a serious and potentially deadly disorder that affects about 5 percent of pregnancies, researchers have found results in mice that may have important implications for diagnosis and treatment in humans.
先兆子痫是一种严重的具有潜在致死性的疾病，它威胁着5%的孕产妇。在最新的一项由March of Dimes资助的研究中，科学家们在老鼠身上的研究结果也许在诊断和治疗该疾病方面对于人类具有重要意义。
Yang Xia, M.D., Ph.D., and Rodney E. Kellems, Ph.D., Department of Biochemistry and Molecular Biology; and Susan M. Ramin, M.D., Department of Obstetrics, Gynecology and Reproductive Science, all at the University of Texas-Houston Medical School, and colleagues report today in the journal Nature Medicine that they induced pre-eclampsia in mice by injecting them with certain human autoantibodies that have been found in women with pre-eclampsia. The mice showed multiple features of the disorder, including dangerously high blood pressure, protein in the urine, and placental abnormalities. Then the researchers gave the mice a substance that blocks the action of the autoantibodies; this prevented the development of pre-eclampsia.
一个由德克萨斯——休斯顿医科大学生物化学和分子生物学部的Yang Xia博士，Rodney E. Kellems博士和妇产科学和生殖科学部的Susan M. Ramin博士组成的团队今天在《自然医学》杂志上发表文章称:他们通过在小鼠身上注入一种在人类先兆子痫患者体内发现的一种自身抗体，从而诱导小鼠的先兆子痫模型。这些小鼠出现了各种各样的症状，包括严重的高血压，蛋白尿和胎盘的异常。紧接着，研究人员给小鼠注射了一种中和这种抗体的物质。这一措施阻断了先兆子痫病程的进一步发展。
The investigators say they demonstrated an important pathway of pre-eclampsia as well as a potential new approach to diagnosis and treatment.
科学家们说，他们证实了先兆子痫发病的重要途径，也许这还是一种诊断和治疗该疾病的一种潜在方法。
Pre-eclampsia may require pre-term delivery (birth before 37 completed weeks gestation) to prevent severe complications to mother and baby, because delivery is the only cure for the disorder.
先兆子痫需要提前分娩来避免对母婴带来的更严重的并发症，因为提前分娩是治疗该疾病的唯一方法。
Preterm birth is a serious and costly health problem and the leading cause of death in the first month of life. More than a half million babies - one out of every eight - are born too soon each year in the United States. Babies who survive face the risk of serious life-long health problems including learning disabilities, cerebral palsy, blindness, hearing loss, and other chronic conditions including asthma. Even infants born just a few weeks too soon have a greater risk of breathing problems, feeding difficulties, temperature instability (hypothermia), jaundice and delayed brain development.
早产是一个严重而且费钱的健康问题，也是导致产后第一个月新生儿死亡的重要原因。在美国，每年有50万早产儿，相当于八个新生儿中就有一个早产儿。幸存下来的早产儿面临着严重的，终身的健康问题，比如智力低下，脑瘫，失明，失聪和一些包括哮踹在内的慢性疾病。甚至在产后的最初几周内也面临着严重的健康威胁。包括呼吸抑制，喂养困难，体温不稳（低体温），新生儿黄疸和大脑发育迟缓等。
The March of Dimes also is helping to support a large World Health Organization study to evaluate whether a new screening test is in fact a reliable predictor of the development of pre-eclampsia, as well as the feasibility of doing testing in developing nations where pre-eclampsia causes a significant number of deaths among pregnant women and babies.
March of Dimes 组织还参与支持了一项世界卫生组织的研究，该研究评估一项新的关于先兆子痫的筛选试验是否可靠，以及该试验用于那些饱受该疾病困扰的发展中国家的可行性。

2008-07-29 13:27

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mikeliu 编辑于 2008-07-29 18:16

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背景知识
1.先兆子痫(也称为子痫前期)以前也叫妊娠毒血症和妊高症，是一种较为复杂的疾病，影响到5%～8%怀孕女性。你如果在怀孕20周后出现高血压和尿蛋白，就会被诊断为先兆子痫。这种病症大多数在37周后才开始有所表现，但也可以在怀孕的后半期、分娩时、甚至产后(一般是在产后24～48小时)的任何时间内表现出来。在怀孕的前20周内也有可能发生先兆子痫，但这种情况很少
2.先兆子痫进一步发展还会引起抽搐，这被称为子痫。抽搐后死亡率相当高。
3.关于March of Dimes ，是一个组织。该组织致力于母婴健康方面的研究和工作。（The first great polio epidemic in the U.S. was in 1916. The disease infected mostly children, killing thousands and leaving many more paralyzed. On a summer day in 1921, Franklin D. Roosevelt became one of its victims and the March of Dimes was born.）

2008-07-29 13:35

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