• 论坛首页
  • 我的丁香客
  • 找人
    查找好友
  • 更多
    丁香园
    丁香通
    丁香人才
    丁香会议
    丁香搜索
    丁香医生
    丁香无线
    丁香导航
    丁当铺
    文献求助
    医药数据库
    丁香诊所
    来问医生
登录 注册

科技动态

关注今日：0 | 主题：423412
论坛首页  >  医药生命科学动态跟踪
  • 发帖
    每发1个新帖
    可以获得0.5个丁当奖励
  • 回帖

分享到：

  • 微信

    微信扫一扫

  • 微博
  • 丁香客
  • 复制网址

【medical-news】戴维病在莫桑比克发病情况的种族调查研究

  • 只看楼主
  • 页码直达：
  • 直达末页
楼主 宝宝doctor
宝宝doctor
质控科
铁杆站友

  • 35
    积分
  • 38
    得票
  • 260
    丁当
  • 1楼
这个帖子发布于12年零286天前，其中的信息可能已发生改变或有所发展。
A Population Study of Endomyocardial Fibrosis in a Rural Area of Mozambique

ABSTRACT

Background Endomyocardial fibrosis is the most common restrictive cardiomyopathy worldwide. It has no specific treatment and carries a poor prognosis, since most patients present with advanced heart failure. On the basis of clinical series, regional variations in distribution have been reported within several countries in Africa, Asia, and South America, but large-scale data are lacking on the epidemiologic features and early stages of the disease.

Methods We used transthoracic echocardiography to determine the prevalence of endomyocardial fibrosis in a rural area of Mozambique. We screened a random sample of 1063 subjects of all age groups selected by clustering. Major and minor diagnostic criteria were defined, and a severity score was developed and applied. Cases were classified according to the distribution and severity of the lesions in the heart.

Results The estimated overall prevalence of endomyocardial fibrosis was 19.8%, or 211 of 1063 subjects (95% confidence interval [CI], 17.4 to 22.2). The prevalence was highest among persons 10 to 19 years of age (28.1%, or 73 of 260 subjects [95% CI, 22.6 to 33.6]) and was higher among male than among female subjects (23.0% vs. 17.5%, P=0.03). The most common form was biventricular endomyocardial fibrosis (a prevalence of 55.5%, or 117 of 211 subjects [95% CI, 48.8 to 62.2]), followed by right-sided endomyocardial fibrosis (a prevalence of 28.0%, or 59 of 211 subjects [95% CI, 21.9 to 34.1]). Most affected subjects had mild-to-moderate structural and functional echocardiographic abnormalities. Only 48 persons with endomyocardial fibrosis (22.7%) were symptomatic. The frequency of familial occurrence was high.

Conclusions Endomyocardial fibrosis is common in a rural area of Mozambique. By using echocardiography, we were able to detect early, asymptomatic stages of the disease. These findings may aid in the study of the pathogenesis of the disease and in the development of new management strategies.

Echocardiograms Showing Types and Degrees of Severity of Endomyocardial Fibrosis.
Panel A shows mild left endomyocardial fibrosis with occupation of the left ventricular apex (arrow). The interventricular septum is dense, with a thickened anterior mitral leaflet. Panel B shows moderate right endomyocardial fibrosis, with obliteration of the trabecular part and fibrous floor of the right ventricular cavity (arrow). The right atrium (RA) is dilated. Panel C shows severe bilateral endomyocardial fibrosis, with obliteration of the left ventricular apex (arrow), thickened valves, and biatrial dilatation
http://content.nejm.org/cgi/content/full/359/1/43
  • 邀请讨论

    • 不知道邀请谁？试试他们

    换一换
2008-07-05 08:07 浏览 : 527 回复 : 3
  • 投票
  • 收藏
  • 打赏
  • 引用
  • 分享

    • 微信扫一扫

    • 新浪微博
    • 丁香客
    • 复制网址
  • 举报
    • 广告宣传推广
    • 政治敏感、违法虚假信息
    • 恶意灌水、重复发帖
    • 违规侵权、站友争执
    • 附件异常、链接失效
    • 其他
  • • 因疯狂敛财，哈尔滨第一医院原院长孟庆刚被开除党籍
zbwzmc
zbwzmc
风湿科
铁杆站友

  • 21
    积分
  • 33
    得票
  • 680
    丁当
  • 2楼
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。
2008-12-23 22:17
  • 投票
  • 收藏
  • 打赏
  • 引用
  • 分享

    • 微信扫一扫

    • 新浪微博
    • 丁香客
    • 复制网址
  • 举报
    • 广告宣传推广
    • 政治敏感、违法虚假信息
    • 恶意灌水、重复发帖
    • 违规侵权、站友争执
    • 附件异常、链接失效
    • 其他
  • • 新冠疫苗的奥秘——如何选择疫苗抗原？（转载）
zbwzmc
zbwzmc
风湿科
铁杆站友

  • 21
    积分
  • 33
    得票
  • 680
    丁当
  • 3楼
A Population Study of Endomyocardial Fibrosis in a Rural Area of Mozambique
戴维病（心肌心内膜纤维化）在莫桑比克农村范围内发病情况的种族调查研究
ABSTRACT
摘要
Background Endomyocardial fibrosis is the most common restrictive cardiomyopathy worldwide.
It has no specific treatment and carries a poor prognosis, since most patients present with advanced heart failure. On the basis of clinical series, regional variations in distribution have been reported within several countries in Africa, Asia, and South America, but large-scale data are lacking on the epidemiologic features and early stages of the disease.
背景：戴维病（心肌心内膜纤维化）是世界范围内最常见的限制性心肌病。戴维病（心肌心内膜纤维化）没有特效疗法、预后也不良，得病以后大部分病人伴发有比较严重的心力衰竭。基于临床各种研究分型，在非洲、亚洲和南美洲几个国家已有报道戴维病（心肌心内膜纤维化）在分布上的地域性变更，但在流行病学特征和疾病早期情况方面还缺少大规模的数据资料分析。
Methods We used transthoracic echocardiography to determine the prevalence of endomyocardial fibrosis in a rural area of Mozambique. We screened a random sample of 1063 subjects of all age groups selected by clustering.Major and minor diagnostic criteria were defined, and a severity score was developed and applied. Cases were classified according to the distribution and severity of the lesions in the heart.
我们用经胸壁超声心动图来确定戴维病（心肌心内膜纤维化）在莫桑比克农村范围内发病情况。我们筛选了随机抽样的由所有年龄组组成的1063个受检者为调查对象。并确定了主要和次要的诊断标准，产生并应用了根据病心肌病损严重度来区分的评分标准。病例是按照分布心脏损害的严重度来分类的。
Results The estimated overall prevalence of endomyocardial fibrosis was 19.8%, or 211 of 1063 subjects (95% confidence interval [CI], 17.4 to 22.2). The prevalence was highest among persons 10 to 19 years of age (28.1%, or 73 of 260 subjects [95% CI, 22.6 to 33.6]) and was higher among male than among female subjects (23.0% vs. 17.5%, P=0.03). The most common form was biventricular endomyocardial fibrosis (a prevalence of 55.5%, or 117 of 211 subjects [95% CI, 48.8 to 62.2]), followed by right-sided endomyocardial fibrosis (a prevalence of 28.0%, or 59 of 211 subjects [95% CI, 21.9 to 34.1]). Most affected subjects had mild-to-moderate structural and functional echocardiographic abnormalities. Only 48 persons with endomyocardial fibrosis (22.7%) were symptomatic. The frequency of familial occurrence was high.
结果所有戴维病（心肌心内膜纤维化）的发病率是19.8%，或是1063个受检者中的211个（患病）（95% CI, 17.4 to 22.2）。在10-19岁人群中的患病率是最高的（28.1%，或是260个人中有73个患病[95% CI, 22.6 to 33.6]），还有在男性受试人群中的发病率要比女性高(23.0% vs. 17.5%, P=0.03)。最常见的一种形式是双心室受累的戴维病（心肌心内膜纤维化）（55.5%的发病率，或是211位受检者中有117位发病[95% CI, 48.8 to 62.2]），其次是单纯右室受累的戴维病（心肌心内膜纤维化）（28.0%的发病率，或是211位受检者中有59位发病[95% CI, 21.9 to 34.1]）。大部分受累的受检者有超声心动图显示的轻到中度的结构和功能异常。其中只有48位（(22.7%）戴维病（心肌心内膜纤维化）表现有症状。然而家族发病率在上升。
Conclusions Endomyocardial fibrosis is common in a rural area of Mozambique. By using echocardiography, we were able to detect early, asymptomatic stages of the disease. These findings may aid in the study of the pathogenesis of the disease and in the development of new management strategies.
结论：戴维病（心肌心内膜纤维化）在莫桑比克农村范围内比较常见。通过超声心动图的应用，我们能早期的在疾病还没有症状时期发现。这些发现可能有助于该病发病机理的研究和新的治疗策略的研制。
Echocardiograms Showing Types and Degrees of Severity of Endomyocardial Fibrosis.
Panel A shows mild left endomyocardial fibrosis with occupation of the left ventricular apex (arrow). The interventricular septum is dense, with a thickened anterior mitral leaflet. Panel B shows moderate right endomyocardial fibrosis, with obliteration of the trabecular part and fibrous floor of the right ventricular cavity (arrow). The right atrium (RA) is dilated. Panel C shows severe bilateral endomyocardial fibrosis, with obliteration of the left ventricular apex (arrow), thickened valves, and biatrial dilatation
超声心动图能对戴维病（心肌心内膜纤维化）分型和判定其严重程度。
图A显示的是左室心尖部箭头指示处轻度心肌心内膜纤维化。室间隔回声增高，伴有二尖瓣前叶回声增粗增强。图B显示中度右室心肌心内膜纤维化右室心底部的小梁和肌纤维（回声增粗增强）充填于右室心底部（箭头所指处）。右房增大。图C显示严重的两侧（心室）心肌心内膜纤维化，伴有左室箭头所指处闭塞、瓣膜增厚和双房增大。
2008-12-25 18:31
  • 投票
  • 收藏
  • 打赏
  • 引用
  • 分享

    • 微信扫一扫

    • 新浪微博
    • 丁香客
    • 复制网址
  • 举报
    • 广告宣传推广
    • 政治敏感、违法虚假信息
    • 恶意灌水、重复发帖
    • 违规侵权、站友争执
    • 附件异常、链接失效
    • 其他
zbwzmc 编辑于 2008-12-25 18:37
  • • 看乡镇医院如何留住人
zbwzmc
zbwzmc
风湿科
铁杆站友

  • 21
    积分
  • 33
    得票
  • 680
    丁当
  • +1 积分
  • 4楼
戴维病（心肌心内膜纤维化）在莫桑比克农村范围内发病情况的种族调查研究

摘要

背景：戴维病（心肌心内膜纤维化）是世界范围内最常见的限制性心肌病。戴维病（心肌心内膜纤维化）没有特效疗法、预后也不良，得病以后大部分病人伴发有比较严重的心力衰竭。基于临床各种研究分型，在非洲、亚洲和南美洲几个国家已有报道戴维病（心肌心内膜纤维化）在分布上的地域性变更，但在流行病学特征和疾病早期情况方面还缺少大规模的数据资料分析。

我们用经胸壁超声心动图来确定戴维病（心肌心内膜纤维化）在莫桑比克农村范围内发病情况。我们筛选了随机抽样的由所有年龄组组成的1063个受检者为调查对象。并确定了主要和次要的诊断标准，产生并应用了根据病心肌病损严重度来区分的评分标准。病例是按照分布心脏损害的严重度来分类的。

结果所有戴维病（心肌心内膜纤维化）的发病率是19.8%，或是1063个受检者中的211个（患病）（95% CI, 17.4 to 22.2）。在10-19岁人群中的患病率是最高的（28.1%，或是260个人中有73个患病[95% CI, 22.6 to 33.6]），还有在男性受试人群中的发病率要比女性高(23.0% vs. 17.5%, P=0.03)。最常见的一种形式是双心室受累的戴维病（心肌心内膜纤维化）（55.5%的发病率，或是211位受检者中有117位发病[95% CI, 48.8 to 62.2]），其次是单纯右室受累的戴维病（心肌心内膜纤维化）（28.0%的发病率，或是211位受检者中有59位发病[95% CI, 21.9 to 34.1]）。大部分受累的受检者有超声心动图显示的轻到中度的结构和功能异常。其中只有48位（(22.7%）戴维病（心肌心内膜纤维化）表现有症状。然而家族发病率在上升。

结论：戴维病（心肌心内膜纤维化）在莫桑比克农村范围内比较常见。通过超声心动图的应用，我们能早期的在疾病还没有症状时期发现。这些发现可能有助于该病发病机理的研究和新的治疗策略的研制。
超声心动图能对戴维病（心肌心内膜纤维化）分型和判定其严重程度。图A显示的是左室心尖部箭头指示处轻度心肌心内膜纤维化。室间隔回声增高，伴有二尖瓣前叶回声增粗增强。图B显示中度右室心肌心内膜纤维化右室心底部的小梁和肌纤维（回声增粗增强）充填于右室心底部（箭头所指处）。右房增大。图C显示严重的两侧（心室）心肌心内膜纤维化，伴有左室箭头所指处闭塞、瓣膜增厚和双房增大。
2008-12-25 18:36
  • 投票 1
  • 收藏
  • 打赏
  • 引用
  • 分享

    • 微信扫一扫

    • 新浪微博
    • 丁香客
    • 复制网址
  • 举报
    • 广告宣传推广
    • 政治敏感、违法虚假信息
    • 恶意灌水、重复发帖
    • 违规侵权、站友争执
    • 附件异常、链接失效
    • 其他
  • • 2021【儿科】中级考试集结地，欢迎讨论你的考后感受！

关闭提示

需要2个丁当

丁香园旗下网站

  • 丁香园
  • 用药助手
  • 丁香通
  • 文献求助
  • 丁香人才
  • 丁香医生
  • 丁香导航
  • 丁香会议
  • 手机丁香园
  • 医药数据库

关于丁香园

  • 关于我们
  • 丁香园标志
  • 友情链接
  • 联系我们
  • 加盟丁香园
  • 版权声明
  • 资格证书

官方链接

  • 丁香志
  • 丁香园新浪微博
引用回复