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【medical-news】冰冻球囊消融对肺静脉分离有效

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Cryoballoon ablation shows promise for pulmonary vein isolation
24 March 2009

MedWire News: Cryoballoon ablation of the pulmonary vein appears to be an effective and straightforward method for treating paroxysmal atrial fibrillation (AF), a clinical trial has shown.

Pulmonary vein isolation (PVI) using radiofrequency current ablation is an established treatment for AF but the technique is complex and associated with a high risk for complications, limiting its clinical application.

The latest research evaluated a new approach to PVI in which cryothermal energy was applied via a balloon catheter. This technique enables a “single shot” PVI by placing the balloon at the PV ostium and ablating circumferentially around the PV ostia with a single energy application, the researchers explain.

Furthermore, cryothermal energy may have advantages over other energy sources since the risk for PV stenosis, atrio-esophageal fistulae, and thrombus formation is low or even absent.

In this study, Karl Heinz Kuck (Asklepios Klinik St Georg, Hamburg, Germany) and colleagues used a 28-mm cryoballoon to isolate the pulmonary vein in 27 patients with highly symptomatic paroxysmal AF that persisted despite anti-arrhythmic drug therapy.

PVI was achieved in 98% of pulmonary veins, say the researchers, and the median procedural, balloon, and fluoroscopy times were 220, 130, and 50 minutes, respectively.

There were three cases of transient phrenic nerve palsy but no cases of pulmonary vein stenosis. After a median follow-up of 271 days, 70% of patients remained in sinus rhythm.

“Using the single big cryoballoon technique, almost all pulmonary veins (98%) could be electrically isolated without left atrium imaging and may reduce the incidence of phrenic nerve palsy as long as distal ablation inside the septal pulmonary veins is avoided,” Chun et al conclude.

“Randomized studies comparing cryoballoon ablation with conventional radiofrequency current energy will be necessary to assess efficacy, complications, and cost-efficacy.”
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http://www.incirculation.net/NewsItem/Cryoballooon-ablation-shows-promise-for-pulmonary-.aspx

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2009-03-25 18:12 浏览 : 1509 回复 : 11

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本人已认领该文献编译 48小时如仍未提交请其他战友自由认领

2009-03-25 18:13

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Cryoballoon ablation shows promise for pulmonary vein isolation
24 March 2009
冰冻球囊消融对肺静脉分离有效 2009-3-24
MedWire News: Cryoballoon ablation of the pulmonary vein appears to be an effective and straightforward method for treating paroxysmal atrial fibrillation (AF), a clinical trial has shown.
MEDWIRE新闻：一项临床实验显示，肺静脉冰冻球囊消融对治疗阵发性房颤有效且直接。
Pulmonary vein isolation (PVI) using radiofrequency current ablation is an established treatment for AF but the technique is complex and associated with a high risk for complications, limiting its clinical application.
使用射频消融进行肺静脉分离是治疗房颤确定的方式。但因其操作复杂，有高的发生并发症的风险而限制了其临床应用。
The latest research evaluated a new approach to PVI in which cryothermal energy was applied via a balloon catheter. This technique enables a “single shot” PVI by placing the balloon at the PV ostium and ablating circumferentially around the PV ostia with a single energy application, the researchers explain.
最新研究评价了一种新的肺静脉分离的方法，其通过气囊导管使用冷烙能量。研究人员解释说这项技术能通过置于肺静脉口的球囊单次射出“一*”的能量环形消融肺静脉口。
Furthermore, cryothermal energy may have advantages over other energy sources since the risk for PV stenosis, atrio-esophageal fistulae, and thrombus formation is low or even absent.
并且，较其他能源相比，冰冻能量的肺静脉狭窄、房室食管瘘、血栓形成的发生率低甚至不发生。
In this study, Karl Heinz Kuck (Asklepios Klinik St Georg, Hamburg, Germany) and colleagues used a 28-mm cryoballoon to isolate the pulmonary vein in 27 patients with highly symptomatic paroxysmal AF that persisted despite anti-arrhythmic drug therapy.
在此研究中，Karl Heinz Kuck（德国汉堡Asklepios Klinik St Georg医院）等使用28mm冰冻球囊分离了27位尽管持续服用抗心律失常药物但仍有明显症状的阵发性房颤患者的肺静脉。
PVI was achieved in 98% of pulmonary veins, say the researchers, and the median procedural, balloon, and fluoroscopy times were 220, 130, and 50 minutes, respectively.
研究人员说有98%的患者成功进行了肺静脉分离，中间程序、球囊以及透视次数分别为220，130以及50分钟。
There were three cases of transient phrenic nerve palsy but no cases of pulmonary vein stenosis. After a median follow-up of 271 days, 70% of patients remained in sinus rhythm.
有3例出现瞬间的膈神经麻痹，无1例出现肺静脉狭窄。经过中位随访日期271天的后，70%的患者仍保持着窦性心律。
“Using the single big cryoballoon technique, almost all pulmonary veins (98%) could be electrically isolated without left atrium imaging and may reduce the incidence of phrenic nerve palsy as long as distal ablation inside the septal pulmonary veins is avoided,” Chun et al conclude.
“使用单个大冰冻球囊技术，几乎所有（98%）肺静脉能在无左房成像下出现电隔离，可能会减少膈神经麻痹并可避免间隔肺静脉远端消融。”Chun et al总结说。
“Randomized studies comparing cryoballoon ablation with conventional radiofrequency current energy will be necessary to assess efficacy, complications, and cost-efficacy.”
需要随机研究比较冰冻球囊消融和传统的射频电流能量，以评估两者的疗效、并发症和性价比。

2009-03-25 19:01

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冰冻球囊消融对肺静脉分离有效 2009-3-24
MEDWIRE新闻：一项临床实验显示，肺静脉冰冻球囊消融对治疗阵发性房颤有效且直接。
使用射频消融进行肺静脉分离是治疗房颤确定的方式。但因其操作复杂，有高的发生并发症的风险而限制了其临床应用。
最新研究评价了一种新的肺静脉分离的方法，其通过气囊导管使用冷烙能量。研究人员解释说这项技术能通过置于肺静脉口的球囊单次射出“一*”的能量环形消融肺静脉口。
并且，较其他能源相比，冰冻能量的肺静脉狭窄、房室食管瘘、血栓形成的发生率低甚至不发生。在此研究中，Karl Heinz Kuck（德国汉堡Asklepios Klinik St Georg医院）等使用28mm冰冻球囊分离了27位尽管持续服用抗心律失常药物但仍有明显症状的阵发性房颤患者的肺静脉。
研究人员说有98%的患者成功进行了肺静脉分离，中间程序、球囊以及透视次数分别为220，130以及50分钟。
有3例出现瞬间的膈神经麻痹，无1例出现肺静脉狭窄。经过中位随访日期271天的后，70%的患者仍保持着窦性心律。
“使用单个大冰冻球囊技术，几乎所有（98%）肺静脉能在无左房成像下出现电隔离，可能会减少膈神经麻痹并可避免间隔肺静脉远端消融。”Chun et al总结说。
需要随机研究比较冰冻球囊消融和传统的射频电流能量，以评估两者的疗效、并发症和性价比。

2009-03-25 19:04

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