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【medical-news】糖尿病患者的福音：胰岛素吸入剂被证明同样有效

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http://diabetes.webmd.com/news/20100624/inhaled-insulin-may-help-treat-diabetes?ecd=wnl_day_062510

Inhaled Insulin May Help Treat Diabetes
Study Shows Inhaled Insulin May Be an Alternative to Injections for Type 2 Diabetes Patients
By Katrina WoznickiWebMD Health NewsReviewed by Laura J. Martin, MDJune 24, 2010 -- Inhaled insulin proved to be as effective at lowering blood sugar levels as standard insulin injection treatment, and with minimal side effects, among patients with uncontrolled type 2 diabetes, according to a new study.

Reporting in this week's American Diabetes Association meeting and in The Lancet, researchers compared two approaches to managing type 2 diabetes among patients ages 18 to 80 from 10 different countries. The patients were nonsmokers and had poor control of blood sugar despite insulin therapy.

A total of 211 patients received inhaled insulin plus insulin glargine, a long-lasting form of insulin taken by injection, before bedtime to help manage blood sugar. They were compared with a comparison group of 237 patients who did not use the inhaler, but received insulin injections instead.

One year after treatment, the researchers found that:

Blood sugar levels were similar in the two groups; 22% of patients in the inhaled insulin/insulin glargine group reached a goal A1c level of 7% or less while 27% of those solely on insulin injections reached the goal.
Patients using the inhaler gained less weight -- a major concern among diabetes patients. The inhaler group gained only an average of about 2 pounds, whereas the control group gained an average of about 5.5 pounds.
Patients using the inhaler had fewer episodes of hypoglycemia -- a sudden drop in blood sugar -- than those in the comparison group, occurring in 31% of patients on inhaled insulin/insulin glargine group vs. 49% of those in the insulin injection group.
Patients using the inhaler reported more side effects with coughing and upper respiratory infections. Most of the coughing occurred within the first 10 minutes of inhalation and primarily during the first week of treatment and declined as treatment continued.
Prior use of metformin, an oral drug commonly taken to manage blood sugar, did not affect results among the two groups of patients.
"Our findings show that inhaled insulin plus insulin glargine, alone or in combination with an oral ant*** drug such as metformin, is an effective alternative to conventional insulin therapy (biaspart insulin) in uncontrolled type 2 diabetes," study researcher Julio Rosenstock, MD, and colleagues write. "Inhaled insulin ... could provide improved blood sugar control with lower weight gain and rates of hypoglycaemia in many individuals with type 2 diabetes."

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2010-06-27 15:41 浏览 : 773 回复 : 1

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http://diabetes.webmd.com/news/20100624/inhaled-insulin-may-help-treat-diabetes?ecd=wnl_day_062510

Inhaled Insulin May Help Treat Diabetes
胰岛素吸入剂可治疗糖尿病
Study Shows Inhaled Insulin May Be an Alternative to Injections for Type 2 Diabetes Patients
研究显示胰岛素吸入剂可替代胰岛素注射剂治疗2型糖尿病
By Katrina Woznicki
WebMD Health NewsReviewed by Laura J. Martin, MDJune 24, 2010 -- Inhaled insulin proved to be as effective at lowering blood sugar levels as standard insulin injection treatment, and with minimal side effects, among patients with uncontrolled type 2 diabetes, according to a new study.
WebMD健康新闻2010年6月24日报道，一项新的研究结果显示，在难治性2型糖尿病患者中，胰岛素吸入剂被证明在降低血糖水平方面与胰岛素注射剂同样有效，且副作用较少。
Reporting in this week's American Diabetes Association meeting and in The Lancet, researchers compared two approaches to managing type 2 diabetes among patients ages 18 to 80 from 10 different countries. The patients were nonsmokers and had poor control of blood sugar despite insulin therapy.
这篇在本周美国糖尿病协会会议上报道的研究结果发表在《柳叶刀》上。研究者比较了两种胰岛素剂型在来自10个不同国家18-80岁年龄段2型糖尿病患者中的治疗效果。入选的对象为不吸烟者且尽管已接受胰岛素治疗但血糖仍控制不佳者。
A total of 211 patients received inhaled insulin plus insulin glargine, a long-lasting form of insulin taken by injection, before bedtime to help manage blood sugar. They were compared with a comparison group of 237 patients who did not use the inhaler, but received insulin injections instead.
观察组共211名患者接受胰岛素吸入剂联合甘精胰岛素（一种长效胰岛素注射剂，睡觉前注射控制血糖）治疗。对照组237名患者接受胰岛素注射剂治疗。
One year after treatment, the researchers found that:
经过一年的治疗，研究人员发现：
Blood sugar levels were similar in the two groups; 22% of patients in the inhaled insulin/insulin glargine group reached a goal A1c level of 7% or less while 27% of those solely on insulin injections reached the goal. 两组间血糖水平相似；观察组中22%患者A1c水平达到7%及以下，而对照组达标人数为27%。
Patients using the inhaler gained less weight -- a major concern among diabetes patients. The inhaler group gained only an average of about 2 pounds, whereas the control group gained an average of about 5.5 pounds. 应用胰岛素吸入剂的患者体重增加（糖尿病患者较为关心的问题）较少。观察组平均增重2磅，而对照组为5.5磅。
Patients using the inhaler had fewer episodes of hypoglycemia -- a sudden drop in blood sugar -- than those in the comparison group, occurring in 31% of patients on inhaled insulin/insulin glargine group vs. 49% of those in the insulin injection group.
应用胰岛素吸入剂的患者与对照组相比，较少发生低血糖症（血糖突然降低）。其发生频率：观察组vs对照组为31% vs. 49%。
Patients using the inhaler reported more side effects with coughing and upper respiratory infections. Most of the coughing occurred within the first 10 minutes of inhalation and primarily during the first week of treatment and declined as treatment continued.
观察组报道的主要副作用为咳嗽和上呼吸道感染。咳嗽大多数发生在吸入的前十分钟内，主要集中在治疗的第一周，随着治疗的继续而减少。
Prior use of metformin, an oral drug commonly taken to manage blood sugar, did not affect results among the two groups of patients.
以往二甲双胍（一种常见的口服降糖药物）的用药史，对两组间的结果没有影响。
"Our findings show that inhaled insulin plus insulin glargine, alone or in combination with an oral ant*** drug such as metformin, is an effective alternative to conventional insulin therapy (biaspart insulin) in uncontrolled type 2 diabetes," study researcher Julio Rosenstock, MD, and colleagues write. "Inhaled insulin ... could provide improved blood sugar control with lower weight gain and rates of hypoglycaemia in many individuals with type 2 diabetes."
该研究的研究员Julio Rosenstock博士及同事认为，“我们的研究结果显示胰岛素吸入剂加甘精胰岛素单独或联合一种口服降糖药物如二甲双胍，对于传统的混合胰岛素治疗控制不良的2型糖尿病，不惜为一种有效的替代方案。胰岛素吸入剂加甘精胰岛素不仅可以更好地控制血糖，不太容易增加体重，同时可降低许多2型糖尿病患者发生低血糖症的几率。”

===========================================================
整理：
http://diabetes.webmd.com/news/20100624/inhaled-insulin-may-help-treat-diabetes?ecd=wnl_day_062510

胰岛素吸入剂可治疗糖尿病
研究显示胰岛素吸入剂可替代胰岛素注射剂治疗2型糖尿病
WebMD健康新闻2010年6月24日报道，一项新的研究结果显示，在难治性2型糖尿病患者中，胰岛素吸入剂被证明在降低血糖水平方面与胰岛素注射剂同样有效，且副作用较少。
这篇在本周美国糖尿病协会会议上报道的研究结果发表在《柳叶刀》上。研究者比较了两种胰岛素剂型在来自10个不同国家18-80岁年龄段2型糖尿病患者中的治疗效果。入选的对象为不吸烟者且尽管已接受胰岛素治疗但血糖仍控制不佳者。观察组共211名患者接受胰岛素吸入剂联合甘精胰岛素（一种长效胰岛素注射剂，睡觉前注射控制血糖）治疗。对照组237名患者接受胰岛素注射剂治疗。

经过一年的治疗，研究人员发现：
两组间血糖水平相似；观察组中22%患者A1c水平达到7%及以下，而对照组达标人数为27%。
应用胰岛素吸入剂的患者体重增加（糖尿病患者较为关心的问题）较少。观察组平均增重2磅，而对照组为5.5磅。
应用胰岛素吸入剂的患者与对照组相比，较少发生低血糖症（血糖突然降低）。其发生频率：观察组vs对照组为31% vs. 49%。
观察组报道的主要副作用为咳嗽和上呼吸道感染。咳嗽大多数发生在吸入的前十分钟内，主要集中在治疗的第一周，随着治疗的继续而减少。
以往二甲双胍（一种常见的口服降糖药物）的用药史，对两组间的结果没有影响。

该研究的研究员Julio Rosenstock博士及同事认为，“我们的研究结果显示胰岛素吸入剂加甘精胰岛素单独或联合一种口服降糖药物如二甲双胍，对于传统的混合胰岛素治疗控制不良的2型糖尿病，不惜为一种有效的替代方案。胰岛素吸入剂加甘精胰岛素不仅可以更好地控制血糖，不太容易增加体重，同时可降低许多2型糖尿病患者发生低血糖症的几率。”

2010-06-30 22:03

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