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论坛首页  >  医药生命科学动态跟踪   >  精华陈列馆
该话题已被移动 - lightningwing , 2013-08-12 06:07
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【聚焦】走进细胞自噬 [精华]

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楼主 tangdl2000
tangdl2000
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Nature. 2008 Feb 28;451(7182):****-75.

Autophagy fights disease through cellular self-digestion.
自噬通过自我消化抵抗疾病.
Mizushima N, Levine B, Cuervo AM, Klionsky DJ.

Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

Abstract
Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.

PMID: 18305538

  • nature06639.pdf(3783.98k)
2010-09-04 20:03
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楼主 tangdl2000
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Nature. 2009 Apr 30;458(7242):1127-30.

Cytoplasmic functions of the tumour suppressor p53
肿瘤抑制蛋白p53的胞浆功能.
Green DR, Kroemer G.

Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. douglas.green@stjude.org

Abstract
The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.

PMID: 19407794

  • nature07986.pdf(204.12k)
2010-09-04 20:10
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楼主 tangdl2000
tangdl2000
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Nat Rev Mol Cell Biol. 2007 Sep;8(9):741-52.

Self-eating and self-killing: crosstalk between autophagy and apoptosis.
自食和自杀：自噬与凋亡之间的对话
Maiuri MC, Zalckvar E, Kimchi A, Kroemer G.

INSERM, U848, F-94805 Villejuif, France.

Abstract
The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses.

PMID: 17717517

  • nrm2239.pdf(759.41k)
2010-09-04 20:14
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tangdl2000 编辑于 2010-09-04 20:18
  • • 心率40次/分、氧饱和测不出，PCO2 78.9！
楼主 tangdl2000
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Curr Opin Cell Biol. 2010 Apr;22(2):181-5. Epub 2010 Jan 13.

Autophagy regulation by p53
p53调节自噬.
Maiuri MC, Galluzzi L, Morselli E, Kepp O, Malik SA, Kroemer G.

INSERM, U848, F-94805 Villejuif, France.

Abstract
Autophagy is an evolutionarily conserved catabolic pathway that is involved in numerous physiological processes and in multiple pathological conditions including cancer. Autophagy is regulated by an intricate network of signaling cascades that have not yet been entirely disentangled. Accumulating evidence indicates that p53, the best-characterized human tumor suppressor protein, can modulate autophagy in a dual fashion, depending on its subcellular localization. On the one hand, p53 functions as a nuclear transcription factor and transactivates proapoptotic, cell cycle-arresting and proautophagic genes. On the other hand, cytoplasmic p53 can operate at mitochondria to promote cell death and can repress autophagy via poorly characterized mechanisms. This review focuses on the recently discovered function of p53 as a master regulator of autophagy.

PMID: 20044243

  • sdfa.pdf(303.34k)
2010-09-04 20:27
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