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【聚焦】走进细胞自噬 [精华]

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ethel533533

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学习了，非常感谢分享

2010-10-24 10:00

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• 2019年度优秀版主评选开始了，请大家积极参与哦！

yingxue900622

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212楼

楼主太给力了，这么详细的介绍~

2010-10-24 15:08

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• 医生，我好像咽不下去了!

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tangdl2000

丁香园中级站友

213楼

Mol Cell. 2010 Oct 22;40(2):280-93.

Autophagy and the integrated stress response.
自噬与应激反应

Kroemer G, Mariño G, Levine B.

INSERM, U848, 39 rue Calmette Desmoulins, 94805 Villejuif, France; Metabolomics Platform, Institut Gustave Roussy, Pavillon de Recherche 1, 94805 Villejuif, France; Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 20 rue Leblanc, 75015 Paris, France; Université Paris Descartes, Faculté de Médecine, 15 rue de l'Ecole de Médecine, 75006 Paris, France.

Abstract
Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic organelles or cytosolic components. This pathway can be stimulated by multiple forms of cellular stress, including nutrient or growth factor deprivation, hypoxia, reactive oxygen species, DNA damage, protein aggregates, damaged organelles, or intracellular pathogens. Both specific, stimulus-dependent and more general, stimulus-independent signaling pathways are activated to coordinate different phases of autophagy. Autophagy can be integrated with other cellular stress responses through parallel stimulation of autophagy and other stress responses by specific stress stimuli, through dual regulation of autophagy and other stress responses by multifunctional stress signaling molecules, and/or through mutual control of autophagy and other stress responses. Thus, autophagy is a cell biological process that is a central component of the integrated stress response.

Copyright © 2010 Elsevier Inc. All rights reserved.
PMID: 20965422

123beth.pdf(1730.17k)

2010-10-25 05:15

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• 丁香热议——卫生院的真实情况，可能和你想象的不太一样

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tangdl2000

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214楼

Nat Rev Mol Cell Biol. 2010 Nov;11(11):759-63.

TRAPP complexes in membrane traffic: convergence through a common Rab.
TRAPP复合物在膜转运中作用：收敛通过共同的Rab

Barrowman J, Bhandari D, Reinisch K, Ferro-Novick S.

Jemima Barrowman is at the Department of Cell Biology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

Abstract
Transport protein particle (TRAPP; also known as trafficking protein particle), a multimeric guanine nucleotide-exchange factor for the yeast GTPase Ypt1 and its mammalian homologue, RAB1, regulates multiple membrane trafficking pathways. TRAPP complexes exist in three forms, each of which activates Ypt1 or RAB1 through a common core of subunits and regulates complex localization through distinct subunits. Whereas TRAPPI and TRAPPII tether coated vesicles during endoplasmic reticulum to Golgi and intra-Golgi traffic, respectively, TRAPPIII has recently been shown to be reqiured for autophagy. These advances illustrate how the TRAPP complexes link Ypt1 and RAB1 activation to distinct membrane-tethering events.

PMID: 20966969

123+nrm2999.pdf(402.25k)

2010-10-25 05:26

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• 有奖分享-2019年即将过去，怀念吗？来。。。

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