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【bio-news】蛔虫启迪新的败血症治疗方法

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Roundworm Could Provide New Treatment for Sepsis

ScienceDaily (Mar. 11, 2011) — Research by the University of Liverpool has found that systemic inflammation caused by sepsis can be suppressed by a protein which occurs naturally in a type of roundworm.

Sepsis is a serious inflammatory condition, caused by the body over-reacting to infection. The body becomes overwhelmed by bacteria, setting off a series of reactions that lead to inflammation and clotting. It affects around 20 million people worldwide each year, and accounts for a large proportion of intensive care unit admissions.

For the past 30 years, sepsis has largely been treated by antibiotics and maintenance of blood flow. Despite these treatments -- often complicated by antibiotic-induced liver injury or the presence of multi drug-resistant bacteria -- mortality rates for those with severe illness who go into multi-organ damage and septic shock, remain as high as 50%. New treatments for septic shock are of high clinical need.

Findings by an international team, led by Professor Alirio Melendez, based at the University's Medical Research Council Centre for Drug Safety Science in the Institute of Translational Medicine, show that inflammation triggered by bacterial endotoxins in immune cells from patients with sepsis is suppressed by a protein called ES-62 which is secreted by a type of roundworm called Acanthocheilonema viteae.

Roundworms can infect the human digestive tract, lymphatic vessels, skin and muscle. They are extremely common -- particularly in parts of the world with poor sanitation -- and it is estimated that nearly a quarter of the world's population are currently infected. Roundworm can live in the human body for decades without adverse effects or triggering the immune system.

Scientists already know that the protein secreted by roundworm is capable of suppressing inflammation and people infected with worms usually benefit from reduced inflammation if they suffer from conditions such as allergies and autoimmune diseases.

Professor Melendez explained: "The protein secreted by the roundworm stimulates a process called autophagy, a process of 'self-eating' that is essential to clear damage to cellular proteins or organelles and promote cell survival and function during stress situations.

"Autophagy reduces inflammation but at the same time permits the clearance of microbial infection. The findings suggest that ES-62 could be used to induce autophagy and reduce the overwhelming inflammation that is responsible for the massive tissue damage seen in sepsis."

He added: "ES-62 has the therapeutic ability to enhance recovery in septic shock by suppressing and limiting catastrophic inflammatory responses while allowing for bacterial clearance to occur. Administration of ES-62, or a synthetic small molecule derivative, alone or in combination with antibiotics could potentially be used treatment of septic shock as well as other inflammatory diseases."

The research is published in Nature Immunology and was carried out in collaboration with colleagues from the Universities of Strathclyde, Glasgow and the National University of Singapore.

http://www.sciencedaily.com/releases/2011/03/110308101325.htm

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2011-03-11 12:25 浏览 : 661 回复 : 3

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• 王雪强教授康复团队招聘博士后应聘

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2011-03-11 14:29

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• 王雪强教授康复团队招聘博士后应聘

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Roundworm Could Provide New Treatment for Sepsis

蛔虫为脓毒血症治疗带来信息网

ScienceDaily (Mar. 11, 2011) — Research by the University of Liverpool has found that systemic inflammation caused by sepsis can be suppressed by a protein which occurs naturally in a type of roundworm.

每日科学2011年3月11日电----利物浦大学的科学家发现一种蛔虫产生的蛋白可抑制脓毒血症症中的全身性炎症反应

Sepsis is a serious inflammatory condition, caused by the body over-reacting to infection. The body becomes overwhelmed by bacteria, setting off a series of reactions that lead to inflammation and clotting. It affects around 20 million people worldwide each year, and accounts for a large proportion of intensive care unit admissions.
脓毒血症是一种严重的炎症性疾病，是由机体对感染的过度反应所致。机体被细菌击败时可发生一系列反应，如炎症及血液凝固。该病每年全球发病数在2000万左右，是导致患者入住ICU的罪魁祸首。

For the past 30 years, sepsis has largely been treated by antibiotics and maintenance of blood flow. Despite these treatments -- often complicated by antibiotic-induced liver injury or the presence of multi drug-resistant bacteria -- mortality rates for those with severe illness who go into multi-organ damage and septic shock, remain as high as 50%. New treatments for septic shock are of high clinical need.

在过去30多年里，主要通过使用抗菌素和维持血液流动性治疗脓毒血症，但常伴随着抗菌素导致的肝损害和多重耐药性。尽管积极治疗，危重（如发生多器官损害和感染性休克）患者的死亡率仍高达50%，因此临床急需针对感染性休克治疗的新手段。

Findings by an international team, led by Professor Alirio Melendez, based at the University's Medical Research Council Centre for Drug Safety Science in the Institute of Translational Medicine, show that inflammation triggered by bacterial endotoxins in immune cells from patients with sepsis is suppressed by a protein called ES-62 which is secreted by a type of roundworm called Acanthocheilonema viteae.
Alrio Melendez教授率领的一支国际团队，发现细菌内毒素在脓毒血症患者免疫细胞内引发的炎症反应可以被一种蛔虫Acanthocheilonema viteae分泌的名为ES-62的蛋白所抑制。

Roundworms can infect the human digestive tract, lymphatic vessels, skin and muscle. They are extremely common -- particularly in parts of the world with poor sanitation -- and it is estimated that nearly a quarter of the world's population are currently infected. Roundworm can live in the human body for decades without adverse effects or triggering the immune system.

蛔虫可侵犯人的消化道、淋巴管、皮肤及肌肉，蛔虫感染极为普遍，尤其是在卫生条件差的地区，全球几乎四分之一人口正感染蛔虫。蛔虫可寄居在人体内数十年，而无任何不良影响，也不会激活人体免疫系统。

Scientists already know that the protein secreted by roundworm is capable of suppressing inflammation and people infected with worms usually benefit from reduced inflammation if they suffer from conditions such as allergies and autoimmune diseases.

科学家已发现蛔虫分泌的一种的那白可抑制炎症反应，因此感染蛔虫的人如果患有过敏性疾病和自身免疫性疾病，可能因此炎症反应较轻。

Professor Melendez explained: "The protein secreted by the roundworm stimulates a process called autophagy, a process of 'self-eating' that is essential to clear damage to cellular proteins or organelles and promote cell survival and function during stress situations.
Melendez教授说：蛔虫分泌的蛋白可对一种名为自噬的过程产生刺激，这种过程对于应激条件下清除针对细胞蛋白和细胞器的损伤因子、促进细胞存活和功能至关重要

"Autophagy reduces inflammation but at the same time permits the clearance of microbial infection. The findings suggest that ES-62 could be used to induce autophagy and reduce the overwhelming inflammation that is responsible for the massive tissue damage seen in sepsis."
自噬可减轻炎症反应，同时也允许清除导致感染的微生物。该研究表明ES-62可用于诱导自噬发生，并减轻严重炎症反应。

He added: "ES-62 has the therapeutic ability to enhance recovery in septic shock by suppressing and limiting catastrophic inflammatory responses while allowing for bacterial clearance to occur. Administration of ES-62, or a synthetic small molecule derivative, alone or in combination with antibiotics could potentially be used treatment of septic shock as well as other inflammatory diseases."
他还说：ES-62具有治疗潜力，可通过抑制和限制严重炎症反应改善感染性休克的治疗现状，同时允许清除细菌的过程。通过单独给予ES-62或合成小分子衍生物，或联合抗生素可能作为治疗感染性休克和其他感染性疾病的手段

The research is published in Nature Immunology and was carried out in collaboration with colleagues from the Universities of Strathclyde, Glasgow and the National University of Singapore.
该研究发布在《自然---免疫学》杂志上，由利物浦大学，格拉斯哥Strathclyde大学和新加坡国立大学的学者合作完成。

2011-03-15 16:08

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yingtiao 编辑于 2011-03-15 16:32

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蛔虫为脓毒血症治疗带来新希望

每日科学2011年3月11日电----利物浦大学的科学家日前发现一种蛔虫产生的蛋白可抑制脓毒血症症中的全身性炎症反应

脓毒血症是一种严重的炎症性疾病，是由机体对感染的过度反应所致。该病每年全球发病数在2000万左右，是导致患者入住ICU的罪魁祸首。

过去30年中，主要通过使用抗菌素和维持血液流动性治疗脓毒血症，但常伴随着抗菌素导致的肝损害和多重耐药性。尽管积极治疗，危重（如发生多器官损害和感染性休克）患者的死亡率仍高达50%，因此临床急需针对感染性休克治疗的新手段。

由Alrio Melendez教授率领的一支国际团队，发现细菌内毒素在脓毒血症患者免疫细胞内引发的炎症反应可以被一种蛔虫Acanthocheilonema viteae分泌的名为ES-62的蛋白所抑制。

之前科学家已发现蛔虫分泌的蛋白可抑制炎症反应，因此感染蛔虫的人如果患有过敏性疾病和自身免疫性疾病，其炎症反应通常较轻。

Melendez教授说：蛔虫分泌的蛋白可对刺激一种名为自噬的过程，该过程对应激条件下清除细胞蛋白和细胞器损伤因子、促进细胞存活和功能至关重要。自噬过程不仅可减轻炎症，同时还允许体内清除致病微生物的过程，我们的研究表明ES-62可诱导自噬发生，同时减轻严重炎症反应。

Melendez教授指出：ES-62具有治疗潜力，在抑制和限制严重炎症反应的同时，允许清除细菌，从而达到治疗感染性休克的目的。通过单独或联合抗生素可能作为治疗感染性休克和其他感染性疾病的新手段

该研究发布在《自然---免疫学》杂志上，由利物浦大学，格拉斯哥Strathclyde大学和新加坡国立大学的学者合作完成。

2011-03-15 16:17

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yingtiao 编辑于 2011-03-15 16:32

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