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【资讯翻译】3D胰腺癌模型有助于判断临床治疗反应、指导个体化治疗

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原文链接：http://www.newswise.com/articles/3d-organoid-modeling-of-pancreatic-cancer-may-help-predict-clinical-responses-and-personalize-cancer-treatments
3D Organoid Modeling of Pancreatic Cancer May Help Predict Clinical Responses and Personalize Cancer Treatments
The development of a new method to grow three-dimensional organoid cultures of pancreatic tumors directly from patients’ surgical tissue offers a promising opportunity for testing targeted therapies and drug responses and personalizing treatments in a rapid, cost-effective manner. The findings are reported today in the Advance Online issue of the journal Nature Medicine.
“These 3D organoids are, essentially, ‘mini tumors’ in a culture dish,” explains the study’s corresponding author Senthil Muthuswamy, PhD, Director of the Cell Biology Program in the Cancer Research Institute at Beth Israel Deaconess Medical Center (BIDMC) and Visiting Professor at Harvard Medical School. “The organoids have the same properties or traits that are seen in the patient tumor from which they came and, therefore, can serve as an innovative platform for both cancer research and for cancer treatment.”
Scientists have been growing cells in 3D culture for decades. These models are used to help understand various biological processes such as tissue development and cancer growth, and Muthuswamy’s laboratory has spent the past 15 years growing normal and cancer-derived cells from human breast tissue as 3D organoids.
This new paper provides an innovative new direction for this technology. “We have now developed a new methodology to grow human pancreatic tumor cells from surgical tissues and have demonstrated that these tumor organoids recreate both morphology and biology of the cancer tissue in the patient,” says Muthuswamy, who conducted this research while at the University of Toronto. The research team also demonstrated that these clonally derived organoids could be used to identify patient-specific sensitivities to novel therapeutic agents.
“From a research point of view, this organoid approach now provides us with a ‘live’ biobank of tissue for discovery and validation of new drugs and targets and modeling resistance to therapy,” says Muthuswamy. “By using a cohort of patient samples from which we can screen for drugs and mutations, we can begin to understand why some patients respond to a treatment while others do not, and can thereby avoid giving patients unnecessary or ineffective treatments. And from a clinical point of view, this approach could help assist patients and their oncologists in making treatment decisions.”
“Pancreatic cancer is a terrible disease,” said Pier Paolo Pandolfi, MD, PhD, Director of the BIDMC Cancer Center. “Patients diagnosed with locally advanced or metastatic pancreatic cancer have a survival rate of less than three percent. Early detection methods and new treatment strategies are desperately needed. These new pancreatic progenitor organoids and tumor organoids can be used to model pancreatic cancer and for drug screening to identify precision therapy strategies.”
Study coauthors include first author Ling Huang, a postdoctoral fellow in the Muthuswamy lab in the BIDMC Cancer Research Institute. University of Toronto Pancreatic Cancer Surgeon Steven Gallinger, also a study coauthor, played an active role in this work by enabling timely access to tumor tissues. Other coauthors include Audrey Holtzinger, Ishann Jagan, Michael BeGora, Ines Lohse, Nicholas Ngai, Cristina Nostro, Lakshmi B. Muthuswamy, Cheryl Arrowsmith, Michael Roehrl, and Gordon Keller.

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2015-10-28 07:48 浏览 : 1129 回复 : 9

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认领本文翻译，48小时内未完成，请其他战友认领！

2015-10-28 09:00

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3D Organoid Modeling of Pancreatic Cancer May HelpPredict Clinical Responses and Personalize Cancer Treatments
胰腺癌的3D类器官模型可能有助于预测患者的临床反应以及个体化治疗
1、The development of a new method to growthree-dimensional organoid cultures of pancreatic tumors directly frompatients’ surgical tissue offers a promising opportunity for testing targetedtherapies and drug responses and personalizing treatments in a rapid,cost-effective manner. The findings are reported today in the Advance Onlineissue of the journal Nature Medicine.
“These 3D organoids are, essentially, ‘minitumors’ in a culture dish,” explains the study’s corresponding author SenthilMuthuswamy, PhD, Director of the Cell Biology Program in the Cancer ResearchInstitute at Beth Israel Deaconess Medical Center (BIDMC) and VisitingProfessor at Harvard Medical School. “The organoids have the same properties ortraits that are seen in the patient tumor from which they came and, therefore,can serve as an innovative platform for both cancer research and for cancertreatment.”
通过外科手术获取人体组织进行培养胰腺肿瘤三维类器官的新方法的发展为肿瘤的靶向治疗、预测药物反应以及个体化治疗提供了一个快速的经济有效的途径。自然医学杂志今天在其网上发行刊率先报道了这一发现。“这些培养皿中的3D类器官实质上就是小型的肿瘤组织”，此研究的研究者，BID医疗中心癌症研究机构的细胞生物学项目主任及哈佛医学院的客座教授SenthilMuthuswamy解释道，“这些类器官被看做与来自人体的肿瘤具有相同的特征或属性，它们可以为癌症研究及癌症治疗提供研究创新平台。”
2、Scientists have been growing cells in 3D culture for decades.These models are used to help understand various biological processes such astissue development and cancer growth, and Muthuswamy’s laboratory has spent thepast 15 years growing normal and cancer-derived cells from human breast tissueas 3D organoids.
科学家们已经将细胞在3D培养皿中培养了数十年。这些模型帮助他们认识到各种复杂的生物进程如组织发育及肿瘤生长，Muthuswamy实验室在过去的15年中将来自人体乳腺组织的正常和癌症细胞培养成3D类器官。
3、This new paper provides an innovative new direction for thistechnology. “We have now developed a new methodology to grow human pancreatictumor cells from surgical tissues and have demonstrated that these tumororganoids recreate both morphology and biology of the cancer tissue in thepatient,” says Muthuswamy, who conducted this research while at the Universityof Toronto. The research team also demonstrated that these clonally derivedorganoids could be used to identify patient-specific sensitivities to noveltherapeutic agents.
“From a research point of view, this organoidapproach now provides us with a ‘live’ biobank of tissue for discovery andvalidation of new drugs and targets and modeling resistance to therapy,” saysMuthuswamy. “By using a cohort of patient samples from which we can screen fordrugs and mutations, we can begin to understand why some patients respond to atreatment while others do not, and can thereby avoid giving patients unnecessaryor ineffective treatments. And from a clinical point of view, this approachcould help assist patients and their oncologists in making treatment decisions.”
此份报道为这种技术提供了一种新的创新研究方向。“我们现在已经发明了一种培养来自人体胰腺肿瘤组织新的方法，并且已经证实这些肿瘤类器官能够完成患者体内癌组织的形态和生物学的重现，”在多伦多大学期间进行此项研究的Muthuswamy解释道。这个研究团队还证实了这些克隆类器官可以用来鉴定新治疗手段的患者特异性敏感度。“从研究的角度来看，此项类器官研究为我们发现和确证药物、靶向制剂以及模型治疗的耐受性提供了一个活的组织生物样本库，”Muthuswamy解释道，“通过一系列的可以筛选药物或基因突变的患者样本，我们开始了解为什么有些患者对治疗敏感而其他人不敏感，同时我们也可以避免给予患者不必要或者无效的治疗措施。从临床治疗来看，这些方法有助于帮助患者及医生做治疗决定。”
4、“Pancreatic cancer is a terrible disease,” said Pier PaoloPandolfi, MD, PhD, Director of the BIDMC Cancer Center. “Patients diagnosedwith locally advanced or metastatic pancreatic cancer have a survival rate ofless than three percent. Early detection methods and new treatment strategiesare desperately needed. These new pancreatic progenitor organoids and tumororganoids can be used to model pancreatic cancer and for drug screening toidentify precision therapy strategies.”
“胰腺肿瘤是一个非常棘手的疾病，”BIDMC癌症中心的主任Pier Paolo Pandolfi解释道，“确诊为局限性晚期或转移性胰腺癌症的患者生存率不足3成。我们迫切需要更加先进的检测方法和新的治疗措施。这些新的胰腺原始器官和肿瘤类器官可以帮助我们模拟胰腺癌并进行药物筛选，以鉴定治疗措施的准确性。”
5、Study coauthors include first author Ling Huang, a postdoctoralfellow in the Muthuswamy lab in the BIDMC Cancer Research Institute. Universityof Toronto Pancreatic Cancer Surgeon Steven Gallinger, also a study coauthor,played an active role in this work by enabling timely access to tumor tissues.Other coauthors include Audrey Holtzinger, Ishann Jagan, Michael BeGora, Ines Lohse,Nicholas Ngai, Cristina Nostro, Lakshmi B. Muthuswamy, Cheryl Arrowsmith,Michael Roehrl, and Gordon Keller.
共同研究者包括第一作者，BIDMC癌症研究机构Muthuswamy实验室的博士后林煌。另外一个研究者，多伦多大学胰腺癌外科医生Steven Gallinger在研究中也发挥了重要作用，他保证了肿瘤组织的及时获得。其他合作者包括Audrey Holtzinger、 Ishann Jagan、Michael BeGora、Ines Lohse、Nicholas Ngai、Cristina Nostro、Lakshmi B. Muthuswamy、Cheryl Arrowsmith、Michael Roehrl以及Gordon Keller。

2015-10-28 15:29

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胰腺癌的3D类器官模型可能有助于预测患者的临床反应以及个体化治疗通过外科手术获取人体组织进行培养胰腺肿瘤三维类器官的新方法的发展为肿瘤的靶向治疗、预测药物反应以及个体化治疗提供了一个快速的经济有效的途径。自然医学杂志今天在其网上发行刊率先报道了这一发现。“这些培养皿中的3D类器官实质上就是小型的肿瘤组织”，此研究的研究者，BID医疗中心癌症研究机构的细胞生物学项目主任及哈佛医学院的客座教授SenthilMuthuswamy解释道，“这些类器官被看做与来自人体的肿瘤具有相同的特征或属性，它们可以为癌症研究及癌症治疗提供研究创新平台。”
科学家们已经将细胞在3D培养皿中培养了数十年。这些模型帮助他们认识到各种复杂的生物进程如组织发育及肿瘤生长，Muthuswamy实验室在过去的15年中将来自人体乳腺组织的正常和癌症细胞培养成3D类器官。
此份报道为这种技术提供了一种新的创新研究方向。“我们现在已经发明了一种培养来自人体胰腺肿瘤组织新的方法，并且已经证实这些肿瘤类器官能够完成患者体内癌组织的形态和生物学的重现，”在多伦多大学期间进行此项研究的Muthuswamy解释道。这个研究团队还证实了这些克隆类器官可以用来鉴定新治疗手段的患者特异性敏感度。“从研究的角度来看，此项类器官研究为我们发现和确证药物、靶向制剂以及模型治疗的耐受性提供了一个活的组织生物样本库，”Muthuswamy解释道，“通过一系列的可以筛选药物或基因突变的患者样本，我们开始了解为什么有些患者对治疗敏感而其他人不敏感，同时我们也可以避免给予患者不必要或者无效的治疗措施。从临床治疗来看，这些方法有助于帮助患者及医生做治疗决定。”
“胰腺肿瘤是一个非常棘手的疾病，”BIDMC癌症中心的主任PierPaolo Pandolfi解释道，“确诊为局限性晚期或转移性胰腺癌症的患者生存率不足3成。我们迫切需要更加先进的检测方法和新的治疗措施。这些新的胰腺原始器官和肿瘤类器官可以帮助我们模拟胰腺癌并进行药物筛选，以鉴定治疗措施的准确性。”
共同研究者包括第一作者，BIDMC癌症研究机构Muthuswamy实验室的博士后林煌。另外一个研究者，多伦多大学胰腺癌外科医生Steven Gallinger在研究中也发挥了重要作用，他保证了肿瘤组织的及时获得。其他合作者包括Audrey Holtzinger、 Ishann Jagan、Michael BeGora、Ines Lohse、Nicholas Ngai、Cristina Nostro、Lakshmi B. Muthuswamy、Cheryl Arrowsmith、Michael Roehrl以及Gordon Keller。

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2015-10-28 15:31

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tiancai_erbao 编辑于 2015-11-02 21:29

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【资讯翻译】3D胰腺癌模型有助于判断临床治疗反应、指导个体化治疗

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