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【技术产业】基因治疗的新型传送介质

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http://www.medicalnewstoday.com/medicalnews.php?newsid=54276

Development Of New Polymer Delivery Vehicles For Gene Therapy

MIT scientists are reporting synthesis and laboratory tests of a promising new group of degradable polymer delivery vehicles for gene therapy. The polymers are improved versions of materials first described in 2000 that deliver genes efficiently to specific cells.

The lack of a safe, efficient delivery system for DNA has been a major barrier to clinical use of gene therapy. Viruses and various polymer materials have been used in efforts to insert therapeutic genes into diseased cells. However, those systems have disadvantages. Some of the polymer materials, for instance, insert genes into only a small percentage of cells and do not degrade in the body.

Robert Langer and colleagues used laboratory experiments to show that the polymers can deliver DNA to human liver cancer cells. Their report is scheduled for the current (Oct. 15) issue of the weekly Journal of the American Chemical Society.

One polymer has potential for carrying genes to the supply of tiny blood vessels that enables cancer cells to grow and spread. "We are currently testing the targeting effects of this polymer on endothelial cells, and it is envisioned that this delivery system could permit localization and transfection of the tumor vasculature for cancer therapies," the report states.

"Synthesis of Poly (beta-amino Ester)s with Thiol-Reactive Side Chains for DNA Delivery"

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2006-10-19 21:25 浏览 : 864 回复 : 5

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2006-10-19 21:59

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Development Of New Polymer Delivery Vehicles For Gene Therapy
基因治疗新传送介质的发展

MIT scientists are reporting synthesis and laboratory tests of a promising new group of degradable polymer delivery vehicles for gene therapy. The polymers are improved versions of materials first described in 2000 that deliver genes efficiently to specific cells.
MIT科学家报告了在基因治疗中一组有前途的新的可降解传送介质的合成和实验室试验。该聚合物为改良的高敏度温差遥感器？2000年首次对其有效传送基因到特定细胞进行描述。

The lack of a safe, efficient delivery system for DNA has been a major barrier to clinical use of gene therapy. Viruses and various polymer materials have been used in efforts to insert therapeutic genes into diseased cells. However, those systems have disadvantages. Some of the polymer materials, for instance, insert genes into only a small percentage of cells and do not degrade in the body.
缺乏安全、有效的DNA传送系统一直以来是临床基因治疗应用的主要障碍。许多病毒和多种聚合物曾经应用于将治疗性基因插入患病细胞。然而，这些系统由不足之处。有些聚合物，例如，仅能够将基因插入到一小部分细胞中，并且不能够使其在体内降解。

Robert Langer and colleagues used laboratory experiments to show that the polymers can deliver DNA to human liver cancer cells. Their report is scheduled for the current (Oct. 15) issue of the weekly Journal of the American Chemical Society.
Robert Langer及其同事使用试验显示该聚合物能够将 DNA 传送到人类肝癌细胞中。他们的报告发表在《Journal of the American Chemical Society》(Oct. 15)。

One polymer has potential for carrying genes to the supply of tiny blood vessels that enables cancer cells to grow and spread. "We are currently testing the targeting effects of this polymer on endothelial cells, and it is envisioned that this delivery system could permit localization and transfection of the tumor vasculature for cancer therapies," the report states.
有种聚合物携带基因到达为癌细胞供血的毛细血管内。“我们当前正在测试该聚合物对内皮细胞的靶向作用。并且预计在癌症治疗中，其能够转染病使肿瘤脉管系统局限化。”报告中说明。

"Synthesis of Poly (beta-amino Ester)s with Thiol-Reactive Side Chains for DNA Delivery"
“用硫醇-反作用侧链合成多聚物（beta-氨基酯）进行 DNA 传递。”

2006-10-20 11:23

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Development Of New Polymer Delivery Vehicles For Gene Therapy
基因治疗的新型聚合物载体的发展

MIT scientists are reporting synthesis and laboratory tests of a promising new group of degradable polymer delivery vehicles for gene therapy. The polymers are improved versions of materials first described in 2000 that deliver genes efficiently to specific cells.
麻省理工学院的科学家报道了一类新型的可降解多聚物作为基因治疗载体的合成和试验室检测。这种多聚物是在2000年报道过的能够有效的将基因传递给特殊细胞的载体的基础之上经过改造得到的。

The lack of a safe, efficient delivery system for DNA has been a major barrier to clinical use of gene therapy. Viruses and various polymer materials have been used in efforts to insert therapeutic genes into diseased cells. However, those systems have disadvantages. Some of the polymer materials, for instance, insert genes into only a small percentage of cells and do not degrade in the body.
缺乏安全有效的DNA运送系统是基因治疗临床应用的主要瓶颈。病毒和多种聚合物材料曾被用作将治疗性基因插入患病细胞的载体。但是这些系统都有缺点。例如，一些多聚物材料只能将基因转入一小部分细胞，而且不能在人体内降解。

Robert Langer and colleagues used laboratory experiments to show that the polymers can deliver DNA to human liver cancer cells. Their report is scheduled for the current (Oct. 15) issue of the weekly Journal of the American Chemical Society.
Robert Langer和他的同事们通过在试验室中的试验证明了这种多聚物可以将DNA转入人的肝细胞。他们的报道刊载在最近出版(10月15日)的《美国化学学会会刊》上。

One polymer has potential for carrying genes to the supply of tiny blood vessels that enables cancer cells to grow and spread. "We are currently testing the targeting effects of this polymer on endothelial cells, and it is envisioned that this delivery system could permit localization and transfection of the tumor vasculature for cancer therapies," the report states.
一种聚合物能将基因运载到为癌症细胞生长和扩散提供营养的毛细血管处。“我们正在研究这种聚合物对内皮细胞的靶向作用，可以预想这种多聚物可以定位和转染肿瘤的脉管系统，从而可以用于癌症的治疗。”报道中说。

"Synthesis of Poly (beta-amino Ester)s with Thiol-Reactive Side Chains for DNA Delivery"
“基因载体--具有与硫醇基反应活性侧链的多聚β-氨基酯的合成”

2006-10-20 13:37

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武寒编辑于 2006-10-20 15:16

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