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【bio-news】代谢组学平台分析男性不育相关生物标记

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Metabolomics Platform Analyzes Biomarkers Associated With Male Infertility

Molecular Biometrics Presents Results of a Pilot Study Assessing Use of Metabolomic Profiling in Male Infertility at American Society of Reproductive Medicine's 62nd Annual Meeting

NEW ORLEANS, LA and CHESTER, NJ -- (MARKET WIRE) -- October 23, 2006 -- Molecular Biometrics, a privately held metabolomics company, today presented results of a pilot study investigating the use of metabolomic profiling to assess male infertility at the American Society of Reproductive Medicine's 62nd Annual Meeting in New Orleans.

In a poster presentation (P-131) titled "Assessment of oxidative stress levels in semen using spectroscopy-based metabolomic profiling: implications in male infertility" Principle Investigator Ashok Agarwal Ph.D, (et. al.) of The Cleveland Clinic Foundation, presented findings of a pilot study assessing Molecular Biometrics' non-invasive method of spectroscopy-based metabolomic profiling of biomarkers of Oxidative Stress (OS). The study evaluated seminal plasma specimens from four groups of patients with male factor infertility and compared the findings to normal controls.

Oxidative stress has long been implicated as a likely cause of male factor infertility and has been shown to negatively affect sperm and embryo quality, and thus pregnancy outcomes. The study concluded that metabolomic profiling of seminal plasma using NIR spectroscopy will likely have utility as a rapid, non-invasive diagnostic screening test of male infertility by identifying different levels of oxidative stress in seminal plasma.

James Posillico, Ph.D., President and CEO of Molecular Biometrics, commented on the study, "These data show for the first time that metabolomic profiling of Oxidative Stress biomarkers could be an effective method of diagnosing various forms of male factor infertility in a rapid, non-invasive manner. We will be conducting further studies to validate these promising observations and to focus on the development of a simple, cost-effective diagnostic screening test."

Near Infrared (NIR) spectroscopy was used to assess biomarkers of OS in seminal plasma of previously diagnosed patients. Spectral data were then analyzed using the Company's proprietary bioinformatics. In this study, all five groups of specimens showed unique metabolomic profiles, or "signatures," that were statistically different from each other, illustrating different levels of oxidative stress between normal males and those with various forms of male factor infertility. Total analysis time for each specimen was approximately one minute.

Complex interactions between the pro-oxidants and antioxidants are crucial in the maintenance of normal intracellular homeostasis. An imbalance in these reactions results in OS, which is known to affect the quality of spermatozoa, eggs and embryos. Current analytical methods that assess OS rely primarily on biochemical methodologies that are cumbersome, costly and labor intensive. The advent of metabolomic profiling will likely offer a more expeditious and sensitive means of studying mechanisms of OS in male factor infertility.

About Molecular Biometrics:

Molecular Biometrics is a privately held metabolomics company that has developed a novel technology platform based on breakthrough metabolomic and biospectroscopy sciences. These disciplines are used in concert to quantify a sample's molecular biomarker makeup and then convert that data into a novel "metabolomic profile" of health or disease using highly specific and sensitive bioinformatics. Molecular Biometrics' technology platform has broad applications in numerous therapeutic categories, including fertility, maternal fetal medicine, neurodegenerative disease such as Alzheimer's and Parkinson's disease and pulmonary and lactate metabolism. The Company's technology platform will also be used to develop a new family of molecular diagnostics products and has applications in pharmacodiagnostics of drug discovery and development.

Molecular Biometrics' lead product candidate is a rapid, non-invasive test of embryo viability for the in-vitro fertilization (IVF) market, where embryo selection is a pivotal step in the treatment procedure. The Company's cost-effective platform enables identification and simultaneous analysis of multiple small molecule biomarkers, in a single sample, leading to the accurate detection of viable embryos in a cohort group that are capable of producing a pregnancy versus those that are not. This high-speed procedure takes approximately one minute to complete.

Please visit Molecular Biometrics' during ASRM at booth #335.

[Editor's Note: Study abstracts available by visiting http://dbpub.com/lookup/ASRM2006/default.php]

--------------------------------------------------------------------------------
Contact:

Bryan P. Murphy
LaVoie Group
978.745.4200 x 105
Email Contact

SOURCE: Molecular Biometrics

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2006-10-24 09:00 浏览 : 988 回复 : 3

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• 中山大学附属第五医院张亚琴影像组学课题组招聘博士后

johnsonfox

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2006-10-25 10:48

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• 落枕诊治

johnsonfox

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很感谢沙漠梭梭站友的纠正，十分感激！我已按您的意见作了修改，只有一处，我仍坚持原来的译法：即cost-effective 译为低成本不太合适，Metabolomics Platform 并不低廉（low cost），只是性价比高而已，cost-effective在词典中的解释为：有成本效益的，划算的。
Metabolomics Platform Analyzes Biomarkers Associated With Male Infertility
代谢组学平台分析男性不育生物标记
Molecular Biometrics Presents Results of a Pilot Study Assessing Use of Metabolomic Profiling in Male Infertility at American Society of Reproductive Medicine's 62nd Annual Meeting
在第62届美洲生殖医学会年会上，分子生物统计学公司的研究人员发布了运用代谢组学模型进行的预试验结果。
NEW ORLEANS, LA and CHESTER, NJ -- (MARKET WIRE) -- October 23, 2006 --
新奥尔良，洛杉矶和切斯特，新泽西-----（市场有线台）----2006-10-23
Molecular Biometrics, a privately held metabolomics company, today presented results of a pilot study investigating the use of metabolomic profiling to assess male infertility at the American Society of Reproductive Medicine's 62nd Annual Meeting in New Orleans.
今天，在新奥尔良举行的第62届美洲生殖医学会年会上，分子生物统计学（是一家私人代谢组学公司）公司的研究人员展示了他们运用代谢组学模型进行的预试验对男性不育测评的结果。
In a poster presentation (P-131) titled "Assessment of oxidative stress levels in semen using spectroscopy-based metabolomic profiling: implications in male infertility" Principle Investigator Ashok Agarwal Ph.D, (et. al.) of The Cleveland Clinic Foundation, presented findings of a pilot study assessing Molecular Biometrics' non-invasive method of spectroscopy-based metabolomic profiling of biomarkers of Oxidative Stress (OS). The study evaluated seminal plasma specimens from four groups of patients with male factor infertility and compared the findings to normal controls.
在大会一张题为“运用建立在光谱法基础上的代谢组学模型测评精液中的氧化应激水平：男性不育的暗示”的宣传海报中，来自于Cleveland临床基金研究项目负责人Ashok Agarwal博士等发布了他们的研究发现，即运用非侵入性的方法----建立在光谱法基础上的代谢组学氧化应激(OS)生物标记物进行的预试验结果。该项研究对来自5组研究对象（包括4组男性不育病人与1组正常对照）的精浆标本进行了测评。
Oxidative stress has long been implicated as a likely cause of male factor infertility and has been shown to negatively affect sperm and embryo quality,and thus pregnancy outcomes. The study concluded that metabolomic profiling of seminal plasma using NIR spectroscopy will likely have utility as a rapid, non-invasive diagnostic screening test of male infertility by identifying different levels of oxidative stress in seminal plasma.
氧化应激长期以来被认为是男性不育的可能原因并且表明对精子和胚胎质量有负面影响，而这两方面恰恰是能否怀孕的关键所在。该项研究认为将近红外光谱运用在精浆的代谢组学模型中，对男性不育者精浆中不同的氧化应激水平进行非侵入性诊断筛选检查，将会很快得到应用。
James Posillico, Ph.D., President and CEO of Molecular Biometrics, commented on the study, "These data show for the first time that metabolomic profiling of Oxidative Stress biomarkers could be an effective method of diagnosing various forms of male factor infertility in a rapid, non-invasive manner. We will be conducting further studies to validate these promising observations and to focus on the development of a simple, cost-effective diagnostic screening test."
分子生物测定学的CEO兼主任James Posillico博士对该项研究做了评论，“研究结果第一次表明氧化应激生物标记物的代谢组学能作为一种有效的诊断各种形式男性不育的快速、非侵入性的方法，我们将着手进行进一步研究，使这项有前景的研究结果见到实效，并且会重点开发一种简便、合算的诊断检测试剂。”
Near Infrared (NIR) spectroscopy was used to assess biomarkers of OS in seminal plasma of previously diagnosed patients. Spectral data were then analyzed using the Company's proprietary bioinformatics. In this study, all five groups of specimens showed unique metabolomic profiles, or "signatures," that were statistically different from each other, illustrating different levels of oxidative stress between normal males and those with various forms of male factor infertility. Total analysis time for each specimen was approximately one minute.
近红外光谱用来测定已确诊病例精浆中氧化应激的生物标记物。然后用该公司自主知识产权开发的生物信息学工具对光谱数据进行分析。该研究中，五组标本显示出一致的代谢组学特征，或者在统计学上不同于其他组的信息，说明在正常男性和患有不同程度不育症者之间有着不同的氧化应激水平。每一份样本总的分析时间大约在一分钟。
Complex interactions between the pro-oxidants and antioxidants are crucial in the maintenance of normal intracellular homeostasis. An imbalance in these reactions results in OS, which is known to affect the quality of spermatozoa,eggs and embryos. Current analytical methods that assess OS rely primarily on biochemical methodologies that are cumbersome, costly and labor intensive. The advent of metabolomic profiling will likely offer a more expeditious and sensitive means of studying mechanisms of OS in male factor infertility.
在促氧化和抗氧化之间有着复杂的相互作用，这在维持细胞内环境稳定相当重要。这一对平衡被打破将导致氧化应激发生，众所周知这将影响精子、卵子及胚胎的质量。目前的分析氧化应激的手段主要是生化方法，繁琐、昂贵以及费力。代谢组学模型的出现将提供更加迅速和敏感的手段来研究男性不育的氧化应激机制。
About Molecular Biometrics:
有关分子生物测定学
Molecular Biometrics is a privately held metabolomics company that has developed a novel technology platform based on breakthrough metabolomic and biospectroscopy sciences. These disciplines are used in concert to quantify a sample's molecular biomarker makeup and then convert that data into a novel "metabolomic profile" of health or disease using highly specific and sensitive bioinformatics. Molecular Biometrics' technology platform has broad applications in numerous therapeutic categories, including fertility, maternal fetal medicine, neurodegenerative disease such as Alzheimer's and Parkinson's disease and pulmonary and lactate metabolism. The Company's technology platform will also be used to develop a new family of molecular diagnostics products and has applications in pharmacodiagnostics of drug discovery and development.
分子生物测定学是一家私立的代谢组学公司，该公司已经建立了一个新的基于突破代谢组学和生物光谱学的技术平台。该学科被用在量化分子生物标记物的成分，并接着运用高度特异和敏感的生物信息学工具将数据转换成为新的健康或疾病“代谢组学模型”。分子生物测定学的技术平台已经广泛应用在很多治疗学领域，包括生殖、产科、新生儿医学、神经变性疾病如阿尔茨海默病、帕金森病、肺及乳液代谢方面。该公司的技术平台也将用于一种新的分子诊断产品的开发以及用于药物研发的药效诊断方面。
Molecular Biometrics' lead product candidate is a rapid, non-invasive test of embryo viability for the in-vitro fertilization (IVF) market, where embryo selection is a pivotal step in the treatment procedure. The Company's cost-effective platform enables identification and simultaneous analysis of multiple small molecule biomarkers, in a single sample, leading to the accurate detection of viable embryos in a cohort group that are capable of producing a pregnancy versus those that are not. This high-speed procedure takes approximately one minute to complete.
分子生物测定学率先为体外生殖能力检查市场开发了快速、非侵入性的胚胎活力检查候选产品，而胚胎选择是体外受精检查市场治疗程序中关键的一步。该公司划算的平台能够鉴定并同时分析一个简单样本中的多个小分子生物标记物，对那些相对于不能生育人群中的人们，能够很快知道胚胎的活力。这项快速的检查大约会在1分钟内完成。
Please visit Molecular Biometrics' during ASRM at booth #335.
请在美洲生殖医学会（ASRM）#335号展位访问分子生物测定学公司
[Editor's Note: Study abstracts available by visiting http://dbpub.com/lookup/ASRM2006/default.php]
编者按：研究论文的文摘请访问：http://dbpub.com/lookup/ASRM2006/default.php]

2006-10-25 19:21

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johnsonfox 编辑于 2006-10-25 23:09

• 冠状病毒-宿主免疫互作的全景动态机制与干预策略重大研究计划2021年度项目指南

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沙漠梭梭

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1. Molecular Biometrics, a privately held metabolomics company, today presented results of a pilot study investigating the use of metabolomic profiling to assess male infertility at the American Society of Reproductive Medicine's 62nd Annual Meeting in New Orleans.
今天，在新奥尔良举行的第26届美洲生殖医学会年会上，分子生物测定学（是一家私人代谢组学公司）公司的研究人员展示了他们运用代谢组学模型对一名飞行员进行的男性不育测评。
1> 怎么跑出飞行员来了。pilot study是预实验吧，请在文章相应处修改。
2> 是62届
3>presented results of 发布了...的结果
4> Biometrics：生物统计学

2. In a poster presentation (P-131) titled .....The study evaluated seminal plasma specimens from four groups of patients with male factor infertility and compared the findings to normal controls.
1>poster presentation 是会议的海报、宣传介绍。
2>从上下文来看，一共是5组，所以最好写明，文中译的有些歧义。

3. 这对一关系的平衡被打破将导致氧化应激发生.......是生化方法，烦琐（繁琐）、昂贵以及费力。
4. 1> in-vitro fertilization (IVF)：体外受精
2> cost-effective ：译为“低本高效的”是否更合适些？

2006-10-25 21:22

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沙漠梭梭编辑于 2006-10-25 22:32

• 冠状病毒-宿主免疫互作的全景动态机制与干预策略重大研究计划2021年度项目指南

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