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【medical-news】高面包消费量与肾细胞癌发生风险增高有关

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http://www.medicalnewstoday.com/medicalnews.php?newsid=54796

Increased Risk Of Renal Cell Carcinoma And High Bread Consumption Linked

A case-control study of more than 2300 Italians has found a significant association between high bread consumption and renal cell carcinoma. Eating a lot of pasta and rice may also raise the risk, while eating many vegetables may lower the risk. The study published online October 20, 2006 in the International Journal of Cancer, the official journal of the International Union Against Cancer (UICC), and is available via Wiley InterScience at http://www.interscience.wiley.com/journal/ijc.

Renal cell carcinoma (RCC) is the most common type of kidney cancer, and accounts for 2 percent of all adult cancers. Previous studies have shown that diet plays a role in RCC risk, but attempts to discern which foods have harmful or beneficial effects have been inconclusive. To discern the relationship between specific foods and RCC risk, researchers led by Francesca Bravi of the Institute of Pharmacological Research "Mario Negri" in Milan, conducted a large case-control study of 2301 Italians.

Between 1992 and 2004, the researchers enrolled 767 adults diagnosed with RCC and 1534 controls who did not have the disease. Two controls were matched to each case by gender, age range, and location. The researchers collected sociodemographic information, anthropomorphic measures, lifestyle habits and personal and family medical history from each participant. They also administered a 78-item food frequency questionnaire which asked about the average weekly consumption for each item over the previous two years. They then performed statistical analyses to discover odds ratios (OR) with a 95 percent confidence interval.

"A significant direct association was observed for bread consumption (OR=1.94) for the highest compared to the lowest quintile of intake," the researchers report. Those who consumed more bread had a higher RCC risk. A modest non-significant risk increase was also observed for pasta and rice (OR=1.29). By contrast, decreasing risk was associated with increasing intake of poultry, processed meat, and all vegetables, both raw and cooked.

The association between elevated cereal intake (bread, pasta and rice) "may be due to the high glycemic index of these foods and their possible involvement in insulin-like growth factors," the researchers suggest. The inverse relationship between vegetable consumption is consistent with previous studies and may be related to their content of vitamins, micronutrients or elements such as carotenoids, flavonoids and phytosterols.

While the study was limited by the fact that the interviewers who gathered each participant's information and administered the food questionnaire were not blind to case-control status, its strengths include the large sample size and the reproducibility and validity of diet information.

"Our results confirm that diet may play a role on the risk of RCC, and in particular, a moderate cereal and high vegetable consumption may have a favorable effect on this neoplasm," the authors conclude.

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2006-10-26 00:42 浏览 : 503 回复 : 2

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2006-10-26 19:32

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Increased Risk Of Renal Cell Carcinoma And High Bread Consumption Linked
吃面包多了，肾癌危险性增加
A case-control study of more than 2300 Italians has found a significant association between high bread consumption and renal cell carcinoma. Eating a lot of pasta and rice may also raise the risk, while eating many vegetables may lower the risk. The study published online October 20, 2006 in the International Journal of Cancer, the official journal of the International Union Against Cancer (UICC), and is available via Wiley InterScience at http://www.interscience.wiley.com/journal/ijc.
对2300多名意大利人进行病例研究发现，面包消费与肾细胞癌之间存在高度相关关系。大量吃面圈和大米也有类似的效果，多吃蔬菜可以降低这种危险性。本研究发表在10月20日的《世界癌症杂志》，这是国际抗癌组织的机关报，可以在wiley数据库下载。
Renal cell carcinoma (RCC) is the most common type of kidney cancer, and accounts for 2 percent of all adult cancers. Previous studies have shown that diet plays a role in RCC risk, but attempts to discern which foods have harmful or beneficial effects have been inconclusive. To discern the relationship between specific foods and RCC risk, researchers led by Francesca Bravi of the Institute of Pharmacological Research "Mario Negri" in Milan, conducted a large case-control study of 2301 Italians.
肾细胞癌是最常见的肾脏肿瘤，占成人所有肿瘤的2%，此前的研究表明饮食可以影响肾细胞癌的危险性，但是那些食物有害，那些食物有益的研究争议比较大。为了搞清某种食物与肾细胞癌的关系，Francesca Vravi领导下的药物研究人员进行了2301例意大利人的大样本研究。
Between 1992 and 2004, the researchers enrolled 767 adults diagnosed with RCC and 1534 controls who did not have the disease. Two controls were matched to each case by gender, age range, and location. The researchers collected sociodemographic information, anthropomorphic measures, lifestyle habits and personal and family medical history from each participant. They also administered a 78-item food frequency questionnaire which asked about the average weekly consumption for each item over the previous two years. They then performed statistical analyses to discover odds ratios (OR) with a 95 percent confidence interval.
在1992和2004年间，研究者征集了767名诊断为肾细胞癌的病人和1534例对照组，每一例对照按照性别、年龄段和居住位置进行匹配。研究者也收集社会人文信息，人类学特征和生活习惯以及个人和家族的病史，并且对受试者进行78种事物的问卷调查，问询受试者最近两年来每种食物的消耗量。然后他们进行数据统计，寻找95%的优势比。
"A significant direct association was observed for bread consumption (OR=1.94) for the highest compared to the lowest quintile of intake," the researchers report. Those who consumed more bread had a higher RCC risk. A modest non-significant risk increase was also observed for pasta and rice (OR=1.29). By contrast, decreasing risk was associated with increasing intake of poultry, processed meat, and all vegetables, both raw and cooked.
“观察发现面包消耗具有最大的优势比”,食用面包更多的人患肾细胞癌的风险更大。面圈和大米的危险性也增加，但是没有达到统计学检验水准。于此相比，禽类，加工肉类和蔬菜是肾细胞癌的罹患率降低。
The association between elevated cereal intake (bread, pasta and rice) "may be due to the high glycemic index of these foods and their possible involvement in insulin-like growth factors," the researchers suggest. The inverse relationship between vegetable consumption is consistent with previous studies and may be related to their content of vitamins, micronutrients or elements such as carotenoids, flavonoids and phytosterols.
“谷类食物与肾癌发病率之间的联系可能是因为这些食物的高糖，另外可能因为含有具有胰岛素样的生长银子”。蔬菜降低肾癌分别率与此前的研究结果一致，可能是因为此类食物含有丰富的维生素，微量元素例如胡萝卜素，黄酮类和食物固醇。
While the study was limited by the fact that the interviewers who gathered each participant's information and administered the food questionnaire were not blind to case-control status, its strengths include the large sample size and the reproducibility and validity of diet information.
本研究的局限性在于，进行问卷调查的人员没有进行双盲设计，另外一点是样本的大小和采访到的食物信息的有效性。
"Our results confirm that diet may play a role on the risk of RCC, and in particular, a moderate cereal and high vegetable consumption may have a favorable effect on this neoplasm," the authors conclude.
本研究结果证实饮食习惯在肾细胞癌危险因素中具有一定地位,尤其是中量的谷类食物和大量的蔬菜饮食具有较好的保护作用.

2006-10-26 20:34

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