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【medical-news】皮质类固醇长期应用者应该随访骨质疏松情况

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这个帖子发布于14年零71天前，其中的信息可能已发生改变或有所发展。

Regular corticosteroid users should be tracked for osteoporosis

NEW YORK (Reuters Health), Nov 8 - Patients who use high-dose corticosteroids, which are associated with adverse skeletal effects, do not appear to be adequately screened and followed for adverse effects, according to the findings reported in the November issue of Annals of Allergy, Asthma, and Immunology.
"Increased risk of osteoporotic fracture, a well-recognized adverse effect of high-dose corticosteroid exposure, has focused attention on exposure to orally administered corticosteroid drugs." Dr. Maggie Che, of Kaiser Permanente Medical Center, Vacaville, California, and colleagues write

The researchers examined high-dose corticosteroid use, osteoporosis screening and treatment trends in 18,737 subjects taking high-dose oral or inhaled corticosteroids. The patients were drawn from the Kaiser Permanente Medical Center Program in Northern California.

The team reviewed electronic records of inhaled and oral corticosteroid use and osteoporosis intervention in 2002 , and developed an algorithm to quantitate high cumulative exposure to corticosteroids.

High-dose corticosteroid use ranged from 0.2% in young adults to 2.2% in subjects 75 years or older. Of those who used high-dose corticosteroids, 72% used the drugs orally only, 15% used the drugs in the inhaled form only, and 13% used combined oral and inhaled corticosteroids.

Twenty-seven percent of women exposed to oral corticosteroids underwent bone densitometry, compared with only 9% of men. Of those exposed to inhaled corticosteroids, 23% of women and 4% of men underwent bone densitometry.

The team reports that 6% of men and 11% of women receiving oral corticosteroids and 1% of men and 5% of women receiving inhaled corticosteroids filled prescriptions for osteoporosis drugs.

"Our review of the medical literature and the results of this study show a currently unmet need to protect a large number of adults from the potentially adverse skeletal effects of high-dose oral and inhaled corticosteroid drugs," Dr. Che's team concludes.

Administrative databases and algorithms can identify patients on high-dose corticosteroids, "which could be the first step toward evaluating patients for potential bone loss and increased fracture risk, followed by implementation of clinical practice guidelines to reduce morbidity from osteoporosis-related fractures."

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2006-11-12 23:51 浏览 : 848 回复 : 1

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2006-11-13 00:27

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• 首张“新冠患者分子全景图”

melody2007

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Regular corticosteroid users should be tracked for osteoporosis
皮质类固醇长期应用者应该随访骨质疏松情况
NEW YORK (Reuters Health), Nov 8 - Patients who use high-dose corticosteroids, which are associated with adverse skeletal effects, do not appear to be adequately screened and followed for adverse effects, according to the findings reported in the November issue of Annals of Allergy, Asthma, and Immunology.
纽约（路透社健康快讯），11月8日—据变态反应、哮喘及免疫学杂志11月期报道发现，似乎并没有对使用高剂量皮质类固醇并可致骨骼不良作用的患者，进行副作用充分的筛查及随访。
"Increased risk of osteoporotic fracture, a well-recognized adverse effect of high-dose corticosteroid exposure, has focused attention on exposure to orally administered corticosteroid drugs." Dr. Maggie Che, of Kaiser Permanente Medical Center, Vacaville , California , and colleagues write
美国加州瓦卡维尔Kaiser Permanente医学中心的Dr. Maggie Che及其同事写到“高剂量应用皮质类固醇会使骨质疏松性骨折的风险增加已经尽人皆知。现在的关注点在于所应用口服的皮质类固醇药物的曝光量。”
The researchers examined high-dose corticosteroid use, osteoporosis screening and treatment trends in 18,737 subjects taking high-dose oral or inhaled corticosteroids. The patients were drawn from the Kaiser Permanente Medical Center Program in Northern California.
研究者检查了18，737名口服或吸入高剂量皮质类固醇受试者，其皮质类固醇的高剂量使用、骨质疏松症筛查及治疗动态。这些患者来自于加州北部的Kaiser Permanente医学中心计划。
The team reviewed electronic records of inhaled and oral corticosteroid use and osteoporosis intervention in 2002 , and developed an algorithm to quantitate high cumulative exposure to corticosteroids.
研究小组回顾了2002年吸入或口服皮质类固醇及骨质疏松症介入的电子记录，并发明了一种算法来定量计算其对皮质类固醇的高累积曝光。
High-dose corticosteroid use ranged from 0.2% in young adults to 2.2% in subjects 75 years or older . Of those who used high-dose corticosteroids, 72% used the drugs orally only, 15% used the drugs in the inhaled form only, and 13% used combined oral and inhaled corticosteroids.
高剂量皮质醇的使用在受试者中，从年轻人的0.2%到75岁或更大年龄的2.2%。这些受试者中，72%的人仅使用口服药物皮质类固醇，15%的人仅使用喷雾剂，而13%的人两者联合使用。

Twenty-seven percent of women exposed to oral corticosteroids underwent bone densitometry, compared with only 9% of men. Of those exposed to inhaled corticosteroids, 23% of women and 4% of men underwent bone densitometry.
相对只有9%的男性，接受口服皮质类固醇的女性有27%经历骨密度测定。在接受吸入皮质类固醇的人中，23%的女性及4%的男性经历骨密度测定。
The team reports that 6% of men and 11% of women receiving oral corticosteroids and 1% of men and 5% of women receiving inhaled corticosteroids filled prescriptions for osteoporosis drugs.
研究小组报道，接受口服皮质类固醇的患者中6%的男性及11%的女性，接受吸入皮质类固醇德患者中1%的男性及5%的女性要给与骨质酥松药物治疗。
"Our review of the medical literature and the results of this study show a currently unmet need to protect a large number of adults from the potentially adverse skeletal effects of high-dose oral and inhaled corticosteroid drugs," Dr. Che's team concludes.
Dr. Che's 的小组总结“医学文献和这项研究结果的回顾显示，目前需要保护很大数目的人群使其免受口服或吸入高剂量皮质类固醇药物的潜在骨骼副作用。”
Administrative databases and algorithms can identify patients on high-dose corticosteroids, "which could be the first step toward evaluating patients for potential bone loss and increased fracture risk, followed by implementation of clinical practice guidelines to reduce morbidity from osteoporosis-related fractures."
管理数据库及算法能够鉴定高剂量皮质类固醇的患者。“这可能是评估患者潜在骨丢失及骨折风险增加的第一步，随后临床实践原则的完成可帮助降低骨质疏松相关骨折的发病率。”

红字部分是觉得很不对劲的，希望大家给与指正与帮助

2006-11-13 13:57

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melody2007 编辑于 2006-11-13 14:01

• 一个读研期间执医四战四败的医学生内心独白

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