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【medical-news】排卵障碍者乳癌风险下降

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Ovulatory Disorders Tied to Reduced Breast Cancer Risk

By David Douglas

NEW YORK (Reuters Health) Dec 27 - Results of a study involving more than 116,000 women, indicates that those who reported infertility due to an ovulatory disorder had a significantly lower incidence of breast cancer than women who did not report problems conceiving, according to findings published in the December 11/25 issue of the Archives of Internal Medicine.

Dr. Kathryn L. Terry of Harvard School of Public Health, Boston and colleagues note that there have been suggestions of an inverse association between infertility due to ovulatory disorders and breast cancer risk. However, they note that "results are inconsistent across studies and often limited by small samples."

To investigate further, the researchers prospectively evaluated data from the Nurses' Health Study II. This involved female nurses aged 25 to 42 years at baseline.

Information on infertility was assessed every 2 years starting in 1989 and ovulation and incident cases of breast cancer were included through 2001.

During more than 275,000 person-years of follow-up, 1357 cases of invasive breast cancer were diagnosed. Overall, women who had ovulatory disorders had a significantly lower incidence of breast cancer than those who did not. The adjusted hazard ratio was 0.75.

Moreover, the incidence was lowest in women who reported ovulatory disorder and use of ovulation-induction therapy (hazard ratio, 0.60). This was based on data collected between 1995 and 2001.

"Our findings are reassuring since many women and their clinicians are concerned about the long-term implications of infertility treatment," Dr. Terry told Reuters Health.

"However, it is difficult to tease apart the true effect of infertility drugs and infertility, since women who have the most difficultly getting pregnant will most likely be taking infertility drugs the longest," she said.

Arch intern Med 2006;166:2484-2489.

http://www.medscape.com/viewarticle/549956

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2006-12-28 09:21 浏览 : 391 回复 : 1

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Ovulatory Disorders Tied to Reduced Breast Cancer Risk
排卵障碍者乳癌风险下降
By David Douglas
大卫道格拉斯报道
NEW YORK (Reuters Health) Dec 27 - Results of a study involving more than 116,000 women, indicates that those who reported infertility due to an ovulatory disorder had a significantly lower incidence of breast cancer than women who did not report problems conceiving, according to findings published in the December 11/25 issue of the Archives of Internal Medicine.
纽约（路透通讯社卫生版）12月27日报——一项涉及116000多人的研究结果表明被报告有排卵障碍引起的不育症妇女比那些惟有怀孕方面问题的妇女的乳腺癌发病率显著降低，这是根据十二月 11号的25期内科档案发表的发现报告的。
Dr. Kathryn L. Terry of Harvard School of Public Health, Boston and colleagues note that there have been suggestions of an inverse association between infertility due to ovulatory disorders and breast cancer risk. However, they note that "results are inconsistent across studies and often limited by small samples."
波士顿的哈佛大学公共卫生学院的Kathryn L. Terry博士和他的同事提出有排卵障碍所引起的不孕和乳腺癌风险正相关。他们指出“研究结果并不一致且受样本量小限制。”
To investigate further, the researchers prospectively evaluated data from the Nurses' Health Study II. This involved female nurses aged 25 to 42 years at baseline.
为了进一步研究，研究者的期望评估数据来源于护士的健康研究II。这项研究在基线涉及了25-42之间的女性护士。
Information on infertility was assessed every 2 years starting in 1989 and ovulation and incident cases of breast cancer were included through 2001.
从1989年开始不育症信息每两年评估一次，排卵和乳腺癌发病例数包括到2001年。
During more than 275,000 person-years of follow-up, 1357 cases of invasive breast cancer were diagnosed. Overall, women who had ovulatory disorders had a significantly lower incidence of breast cancer than those who did not. The adjusted hazard ratio was 0.75.
在275000多人一年中的随访中，1357个乳腺浸润性癌病例被诊断。总的说来，排卵障碍妇女乳腺癌发病率与那些没有排卵障碍的妇女相比显著降低。调整风险率是0.75。
Moreover, the incidence was lowest in women who reported ovulatory disorder and use of ovulation-induction therapy (hazard ratio, 0.60). This was based on data collected between 1995 and 2001.
而且，在报道中排卵障碍并且应用诱导排卵治疗的妇女发病率最低（风险率，0.60）。这是基于1995-2001年收集的数据得出的研究结果。
"Our findings are reassuring since many women and their clinicians are concerned about the long-term implications of infertility treatment," Dr. Terry told Reuters Health.
Terry博士告诉路透通讯社卫生：“我们的发现从关心长期应用不育症治疗的妇女和她们的医生那里得到验证。”
"However, it is difficult to tease apart the true effect of infertility drugs and infertility, since women who have the most difficultly getting pregnant will most likely be taking infertility drugs the longest," she said.
她说：“然而，分出不孕药真实效应和不孕症是困难的，因为最难怀孕的妇女，将可能是服用避孕药最长期的妇女。”

Arch intern Med 2006;166:2484-2489.
内科档案2006;166:2484-2489.
http://www.medscape.com/viewarticle/549956

编译：

排卵障碍者乳癌风险下降

大卫道格拉斯报道

纽约（路透通讯社卫生版）12月27日报——一项涉及116000多人的研究结果表明被报告有排卵障碍引起的不育症妇女比那些惟有怀孕方面问题的妇女的乳腺癌发病率显著降低，这是根据十二月 11号的25期内科档案发表的发现报告的。

波士顿的哈佛大学公共卫生学院的Kathryn L. Terry博士和他的同事提出有排卵障碍所引起的不孕和乳腺癌风险正相关。他们指出“研究结果并不一致且受样本量小限制。”

为了进一步研究，研究者的期望评估数据来源于护士的健康研究II。这项研究在基线涉及了25-42之间的女性护士。

从1989年开始不育症信息每两年评估一次，排卵和乳腺癌发病例数包括到2001年。

在275000多人一年中的随访中，1357个乳腺浸润性癌病例被诊断。总的说来，排卵障碍妇女乳腺癌发病率与那些没有排卵障碍的妇女相比显著降低。调整风险率是0.75。

而且，在报道中排卵障碍并且应用诱导排卵治疗的妇女发病率最低（风险率，0.60）。这是基于1995-2001年收集的数据得出的研究结果。

Terry博士告诉路透通讯社卫生：“我们的发现从关心长期应用不育症治疗的妇女和她们的医生那里得到验证。”

她说：“然而，分出不孕药真实效应和不孕症是困难的，因为最难怀孕的妇女，将可能是服用避孕药最长期的妇女。”

内科档案2006;166:2484-2489.

http://www.medscape.com/viewarticle/549956

2006-12-28 09:29

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天降大任编辑于 2006-12-28 20:22

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