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【medical-news】拯救更多的乳房

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蓝色幻想

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Saving More Breasts

Main Category: Breast Cancer News
Article Date: 05 Feb 2007 - 0:00 PST

A single tissue sample reveals if you have breast cancer with spread. That means the most aggressive cancer types can be detected at an early stage.

Every year 2800 Norwegian women are diagnosed with breast cancer. Some 800 of them die. The sooner the cancer is detected, the better the chances of survival.

A new method makes it possible to detect the most aggressive types far earlier than previously. At the same time, women with a 'mild' type could be notified quickly that they are out of danger and not have to carry their fears for months without reason.

Ingrid Gribbestad's research group at the MR Centre at The Norwegian University of Science and Technology (NTNU) in Trondheim has been a pioneer in the work of developing the method. The innovation involves looking at the biopsies (breast tissue samples) at molecular level.

"Today, we have to study the cancerous tumours in microscopes and observe the dangerous changes with our bare eyes. We operate on the lower level when it comes to size," Gribbestad says.

Molecular prints

The method involves taking a 'fingerprint' of the molecules in the tissue sample. The principle is already used for liquids such as oil and wine: Fish oils can be traced back to where the salmon came from, while the content of a wine bottle can be traced to a specific vineyard. However, nobody else in the world has managed to transfer the method to a medical analysis of breast cancer before.

"There is no doubt that we are at the top internationally in this area," says Gribbestad.

Based on a normal fingerprint, detectives can say something about the owner's looks and criminal record, if the person's identity is known. In the same way, Gribbestad can say something about the behaviour of a particular cancerous tumour if she knows the history and the molecules of the tumour in question.

That makes it possible, for instance, to establish whether the cancer in this tissue has spread to lymph nodes elsewhere in the body.

Disease profile adaptation

"Another positive aspect is that this 'fingerprint' also indicates whether the patient will respond to the medical treatment we initiate," Gribbestad explains.

That makes it possible to find the patients that should be given chemotherapy even before the operation. In addition, cases where it is safe to remove only the affected tissue instead of the entire breast will be easier to find. More breasts will be spared.

"With this we leave the group treatment for the benefit of individual treatment adapted to each patient's disease profile," concludes Ingrid Gribbestad.

About the THE NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)

The Norwegian University of Science and Technology (NTNU) in Trondheim represents academic eminence in technology and the natural sciences as well as in other academic disciplines ranging from the social sciences, the arts, medicine, architecture to fine arts. Cross-disciplinary cooperation results in ideas no one else has thought of, and creative solutions that change our daily lives.

NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)
Gloshaugen
http://www.ntnu.no/indexe.php

http://www.medicalnewstoday.com/medicalnews.php?newsid=62333

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2007-02-06 12:20 浏览 : 1536 回复 : 6

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蓝色幻想编辑于 2007-02-09 12:21

• 丁香热议——实习逃了两天只为复习，老师上报学校要我退学！

HELLOzhi

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2007-02-06 12:37

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• 丁香早知道 - 12.6 | 没考研的“差生”同学年薪百万，而我还为生存挣扎

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2007-02-06 12:37

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• 良恶性肺结节如何区分？看这一篇就够了！

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Saving More Breasts
拯救更多的乳房

Main Category: Breast Cancer News
Article Date: 05 Feb 2007 - 0:00 PST
主分类：乳腺癌新闻
文章发表日期：2007年2月5日

A single tissue sample reveals if you have breast cancer with spread. That means the most aggressive cancer types can be detected at an early stage.
如果单独检测一小片组织就可以告诉你体内的乳腺癌有没有扩散，那么，这就意味着我们可以在早期诊断出转移能力最强的肿瘤。

Every year 2800 Norwegian women are diagnosed with breast cancer. Some 800 of them die. The sooner the cancer is detected, the better the chances of survival.
在挪威每年都有2800名妇女被诊断为乳腺癌，其中有约800名妇女死于乳腺癌。乳腺癌的诊断时间在病程中越早期，则生存机率越大。

A new method makes it possible to detect the most aggressive types far earlier than previously. At the same time, women with a 'mild' type could be notified quickly that they are out of danger and not have to carry their fears for months without reason.
有一种新方法使人们可能做到这一步，即将恶性程度最高型的乳腺癌在其发生超早期内检验出来，而同时，如果病人患的是乳腺肿瘤是良性的，这种方法也能很快地将其排除，也免去了病人好几个月不必要的担忧。

Ingrid Gribbestad's research group at the MR Centre at The Norwegian University of Science and Technology (NTNU) in Trondheim has been a pioneer in the work of developing the method. The innovation involves looking at the biopsies (breast tissue samples) at molecular level.
Ingrid Gribbestad 的研究小组在Trondheim挪威科技大学MR中心从事研究工作，该小组开创了一个分子水平的病理活体检查方法。

"Today, we have to study the cancerous tumours in microscopes and observe the dangerous changes with our bare eyes. We operate on the lower level when it comes to size," Gribbestad says.
“今天，我们仍是肉眼下利用显微镜进行肿瘤组织学的研究，观察组织是否发生了瘤变，但我们开发的新技术能够在肿瘤更小的情况下及时发现它。”Gribbestad说。

Molecular prints
分子指纹

The method involves taking a 'fingerprint' of the molecules in the tissue sample. The principle is already used for liquids such as oil and wine: Fish oils can be traced back to where the salmon came from, while the content of a wine bottle can be traced to a specific vineyard. However, nobody else in the world has managed to transfer the method to a medical analysis of breast cancer before.
简单地说，新技术就是探测组织样本里分子的“指纹”，原理好比根据鱼油追溯鲑鱼，由酒瓶里的葡萄酒找到相应的葡萄庄园，非常简单，但从来没有人想过将这个道理应用到医学上来，用来检测乳腺癌。

"There is no doubt that we are at the top internationally in this area," says Gribbestad.
Gribbestad说，“无疑，在这个领域上我们是处于国际领先的。”

Based on a normal fingerprint, detectives can say something about the owner's looks and criminal record, if the person's identity is known. In the same way, Gribbestad can say something about the behaviour of a particular cancerous tumour if she knows the history and the molecules of the tumour in question.
如果一个人的身份是在先前确定的，只要根据指纹图谱，利用指纹分析技术，***就可以追查到指纹本人的基本信息及犯罪记录。同样地，只要事先获得某种肿瘤与特定分子间的关系，Gribbestad也可以根据检测到的分子进而描述相应肿瘤的行为。

That makes it possible, for instance, to establish whether the cancer in this tissue has spread to lymph nodes elsewhere in the body.
例如，利用这个技术，就有可能确定这块取材上的癌组织在体内是否转移到其它的淋巴结上。

Disease profile adaptation
适用分析疾病谱：

"Another positive aspect is that this 'fingerprint' also indicates whether the patient will respond to the medical treatment we initiate," Gribbestad explains.
“另外可以肯定的一点是，‘指纹技术’还可以告诉我们，病人的病情是否会对给予的治疗措施有所反应。”Gribbestad说。

That makes it possible to find the patients that should be given chemotherapy even before the operation. In addition, cases where it is safe to remove only the affected tissue instead of the entire breast will be easier to find. More breasts will be spared.
这个技术还可筛选出应该给予化疗的病人，即使是在手术前；另外，也会更容易发现这样的病人，即手术治疗只需切除受浸润的部分而不是整个乳房，只有这样病人才是安全的；总之，新的技术可以使更多的乳腺组织保留下来。

"With this we leave the group treatment for the benefit of individual treatment adapted to each patient's disease profile," concludes Ingrid Gribbestad.
“有了这项技术，我们就可以告别标准的统一的治疗时代，而迎来立足于患者本人的个体治疗时代。”Gribbestad最后总结说。

拯救更多的乳房
主分类：乳腺癌新闻
文章发表日期：2007年2月5日
如果单独检测一小片组织就可以告诉你体内的乳腺癌有没有扩散，那么，这就意味着我们可以在早期诊断出转移能力最强的肿瘤。
在挪威每年都有2800名妇女被诊断为乳腺癌，其中有约800名妇女死于乳腺癌。乳腺癌的诊断时间在病程中越早期，则生存机率越大。
有一种新方法使人们可能做到这一步，即将恶性程度最高型的乳腺癌在其发生超早期内检验出来，而同时，如果病人患的是乳腺肿瘤是良性的，这种方法也能很快地将其排除，也免去了病人好几个月不必要的担忧。
Ingrid Gribbestad 的研究小组在Trondheim挪威科技大学MR中心从事研究工作，该小组开创了一个分子水平的病理活体检查方法。
“今天，我们仍是肉眼下利用显微镜进行肿瘤组织学的研究，观察组织是否发生了瘤变，但我们开发的新技术能够在肿瘤更小的情况下及时发现它。”Gribbestad说。
分子指纹
简单地说，新技术就是探测组织样本里分子的“指纹”，原理好比根据鱼油追溯鲑鱼，由酒瓶里的葡萄酒找到相应的葡萄庄园，非常简单，但从来没有人想过将这个道理应用到医学上来，用来检测乳腺癌。
Gribbestad说，“无疑，在这个领域上我们是处于国际领先的。”
如果一个人的身份是在先前确定的，只要根据指纹图谱，利用指纹分析技术，***就可以追查到指纹本人的基本信息及犯罪记录。同样地，只要事先获得某种肿瘤与特定分子间的关系，Gribbestad也可以根据检测到的分子进而描述相应肿瘤的行为。
例如，利用这个技术，就有可能确定这块取材上的癌组织在体内是否转移到其它的淋巴结上。
适用分析疾病谱：
“另外可以肯定的一点是，‘指纹技术’还可以告诉我们，病人的病情是否会对给予的治疗措施有所反应。”Gribbestad解析。
这个技术还可筛选出应该给予化疗的病人，即使是在手术前；另外，也会更容易发现这样的病人，即手术治疗只需切除受浸润的部分而不是整个乳房，只有这样病人才是安全的；总之，新的技术可以使更多的乳腺组织保留下来。
“有了这项技术，我们就可以告别标准的统一的治疗时代，而迎来立足于患者本人的个体治疗时代。”Gribbestad最后总结说。

2007-02-07 22:59

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HELLOzhi 编辑于 2007-02-10 21:41

• 由「皮肤瘙痒」诊断出「塌陷性肾小球病」怎么做到的？

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