slytjiaofei
Title:Oral Contraceptive Tolerance Does the Type of Pill Matter?
题目：口服避孕药的类型影响其耐受性吗？
Author：Caroline Moreau, MD, PhD1,2, James Trussell, PhD2, Fabien Gilbert, MA1, Nathalie Bajos, PhD3 and Jean Bouyer, PhD1
作者：Caroline Moreau, MD, PhD1,2, James Trussell, PhD2, Fabien Gilbert, MA1, Nathalie Bajos, PhD3 and Jean Bouyer, PhD1
OBJECTIVE: To examine the frequencies of reported symptoms by oral contraceptive pill (OCP) composition among French women.
目的：在口服避孕药(OCP)的法国妇女中调查已报道症状的发生率。
METHODS: A population-based cohort of 2,863 women studied between 2000 and 2004 was used to compare the frequency of reported symptoms (weight gain, nausea, breast tenderness, lower frequency of menstrual periods, breakthrough bleeding, painful and heavy periods, swollen legs) by type of OCPs (classified by estrogen dosage, progestin component, and sequence of administration).
方法：以2000到2004年间2863名妇女的人群队列为对象，比较不同类型OCPs(根据雌激素剂量、孕激素成分和服药顺序进行分类)的已报道症状发生率(体重增加, 恶心, 乳房胀痛, 月经周期频率下降, 突破性出血, 痛经和月经过多, 腿部肿胀)。
RESULTS: Results show little variation in the frequency of symptoms by type of OCPs, with the exception of progestin-only pills being associated with higher frequencies of breakthrough bleeding and lower frequencies of menstrual periods. We found no decrease in the reporting of symptoms with the reduction of estrogen dosage, nor with the use of third-generation OCPs compared with second-generation OCPs. Likewise, we found little variation by sequence of administration of OCPs (monophasic versus triphasic).
结果：除了服用单一孕激素药丸与突破性出血频率升高和月经周期频率降低有关外，结果显示不同OCPs类型与症状的发生率间差异不大。不论是减少雌激素剂量，还是第三代OCPs与第二代OCPs间比较，我们发现都未发现报道症状的减少。同样，我们也未见OCPs服用顺序间存在差异(单相对三相)。
CONCLUSION: In the absence of sufficient evidence-based data to support the existence of differences in the tolerance profile of low-dose combined OCPs, future well-designed randomized trials are needed to guide providers in their choice of OCPs. However, research should also assess the effectiveness of counseling on the tolerance of OCPs, an intervention that may prove to be more rewarding than basing the choice of OCPs on their theoretical properties.
结论：由于缺少足够有证据的资料来支持低剂量复合OCPs存在耐受特性的差异，将来需要有设计良好的随机试验来指导供应者对OCPs的选择。然而，研究也应该评价OCPs耐受咨询的有效性，即与OCPs选择的理论特性相比可能更有益的一种干预。

编译后：共396字
Moreau C及其同事对口服避孕药的类型是否影响其耐受性进行了研究，结果发表在2007.6的《妇产科》杂志。研究人员在口服避孕药(OCP)的法国妇女中调查已报道症状的发生率。他们以2000到2004年间2863名妇女的人群队列为对象，比较不同类型OCPs(根据雌激素剂量、孕激素成分和服药顺序进行分类)的已报道症状发生率(体重增加, 恶心, 乳房胀痛, 月经周期频率下降, 突发性出血, 痛经和月经过多, 腿部肿胀)。除了服用孕激素药丸与突发性出血频率升高和月经周期频率降低有关外，结果显示不同OCPs类型与症状的发生率间差异不大。不论是减少雌激素剂量，还是第三代OCPs与第二代OCPs间比较，我们发现都未发现报道症状的减少。同样，我们也未见OCPs服用顺序间存在差异(单次vs三次)。由于缺少足够有证据的资料来支持低剂量OCPs存在耐受特性的差异，将来需要有设计良好的随机实验来指导供应者对OCPs的选择。然而，研究也应该评价OCPs耐受决策的有效性，即与OCPs选择的理论特性相比可能更有益的一种干预。