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【科普】维生素C并不能阻止大部分成年人感冒

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http://www.medpagetoday.com/PrimaryCare/PreventiveCare/tb/6186
Vitamin C Won't Prevent Colds in Most Adults

By Peggy Peck, Managing Editor, MedPage Today
Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco
July 18, 2007

HELSINKI, Finland, July 18 -- Although most people won't find vitamin C effective protection against colds, marathon runners can cut their risk by about 50% if they take at least 200 mg every day. Action Points

Explain to interested patients that this review found no evidence to support the use of vitamin C for prevention of the common cold.

Explain that the researchers did find evidence to support vitamin C prophylactic use among long distance runners, skiers, or soldiers deployed to sub-artic regions.

Explain, too, that duration of cold symptoms was shorter in adults and children who took vitamin C daily, but taking high doses at the start of a cold had no consistent effect on symptoms.
This latest -- although probably not final -- word on vitamin C comes from a review published online in issue 3 of The Cochrane Library.

Pooled data from more than 11,350 participants in 30 trials found that the relative risk of catching a cold was 0.96 (0.92 to 1.00) for people who took prophylactic vitamin C, said Harri Hemilä, Ph.D., M.D., of the University of Helsinki, a co-author of the review.

The finding suggests that it "doesn't make sense to take vitamin C 365 days a year to lessen the chance of catching a cold," he said.

But a subgroup of six trials that enrolled 642 long distance runners, skiers, and soldiers deployed in sub-arctic regions revealed that vitamin C supplementation reduced by half the risk of catching cold in those populations (RR 0.50, 95% CI 0.38-0.66).

Pooled data from 9,676 people who caught colds while taking the vitamin prophylactically did find that vitamin C reduced the duration of sneezing, congestion, and other cold symptoms by about 8% in adults (95% CI 3% to 13%) and by 13.6% in children (95% CI 5% to 22%).

Trials of high dose vitamin C initiated at the first signs of a cold demonstrated no consistent effect on either duration or severity of symptoms, but, Dr. Hemilä said, there were few such trials in the literature and "their quality was variable."

Vitamin C has steadily gained status as a cold remedy since its discovery in the 1930s, but the mega-vitamin C movement took off in the 1970s when Nobel Prize-winning chemist Linus Pauling published his book, Vitamin C and the Common Cold. Pauling encouraged people to take 1,000 mg of vitamin C daily.

The first Cochrane Review of prophylactic vitamin C was published in 1998. That review was updated in 2004 and this latest update includes a single new study but no change in the Cochrane take on vitamin C.

Dr. Hemilä said he sees little use in further study of the vitamin in colds for adults. However, he would like to see more studies on vitamin C and colds in children and vitamin C and pneumonia.

Vitamin C, he said in a statement, is not a panacea, but it is not useless either. "Pauling was overly optimistic, but he wasn't completely wrong."

Dr. Hemilä disclosed no conflicts. The Commonwealth Department of Health and Aging and the Australian National University funded the study.

Additional Preventive Care Coverage

Primary source: Cochrane Collaboration Cochrane Library
Source reference:
Douglas R.M. "Vitamin C for Preventing and Treating the Common Cold (Review)" Cochrane Database of Systematic Reviews 2007; Issue 3 Published online July 18, 2007 DOI: 10.1002/14651858.CD00980.pub3

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2007-07-19 07:58 浏览 : 870 回复 : 5

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• 丁香晚间病例-地塞米松配伍头孢后，患者迅速死亡

ginnyran

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2007-07-19 16:44

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• 12 月首批公立医院发布招聘计划，含编制岗位

ginnyran

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请战友纠错！多谢！

http://www.medpagetoday.com/PrimaryCare/PreventiveCare/tb/6186
Vitamin C Won't Prevent Colds in Most Adults
维生素C并不能预防大部分成年人感冒
By Peggy Peck, Managing Editor, MedPage Today
Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco
July 18, 2007

HELSINKI, Finland, July 18 -- Although most people won't find vitamin C effective protection against colds, marathon runners can cut their risk by about 50% if they take at least 200 mg every day. Action Points
芬兰赫尔辛基，7月18日---虽然对于大部分人而言，维生素C不能预防感冒，但对于马拉松运动员来说，如果每天服用200mg以上维生素C就可以使感冒风险降低50%。
Explain to interested patients that this review found no evidence to support the use of vitamin C for prevention of the common cold.
告之相关患者，该综述发现并没有证据支持服用维生素C可以预防一般的感冒。
Explain that the researchers did find evidence to support vitamin C prophylactic use among long distance runners, skiers, or soldiers deployed to sub-artic regions.
但研究人员确实找到了支持长跑运动员、滑雪者或部署在亚北极地区士兵预防性服用维生素C的证据。
Explain, too, that duration of cold symptoms was shorter in adults and children who took vitamin C daily, but taking high doses at the start of a cold had no consistent effect on symptoms.
This latest -- although probably not final -- word on vitamin C comes from a review published online in issue 3 of The Cochrane Library.
另外，每天服用维生素C可以缩短成人及儿童的感冒症状持续时间，但在感冒开始时服用高剂量维生素C对于症状却没有相应的改善作用。
这项最新的---即使不是最终的---关于维生素C的综述在线发表在The Cochrane Library第3期上。
Pooled data from more than 11,350 participants in 30 trials found that the relative risk of catching a cold was 0.96 (0.92 to 1.00) for people who took prophylactic vitamin C, said Harri Hemilä, Ph.D., M.D., of the University of Helsinki, a co-author of the review.
该综述的合作者赫尔辛基大学的Harri Hemilä医学博士称，从30项试验11350多名参与者的混合数据发现，预防性服用维生素C的人患感冒的相对危险度为0.96（0.92-1.00）。
The finding suggests that it "doesn't make sense to take vitamin C 365 days a year to lessen the chance of catching a cold," he said.
该发现说明，没有必要为了减少感冒可能性而一年365天每天服用维生素C，他说。
But a subgroup of six trials that enrolled 642 long distance runners, skiers, and soldiers deployed in sub-arctic regions revealed that vitamin C supplementation reduced by half the risk of catching cold in those populations (RR 0.50, 95% CI 0.38-0.66).
但是，包括642名长跑运动员、滑雪者及部署在亚北极地区士兵的6项试验数据显示，补充维生素C可以使这类人群的感冒风险减半（RR 0.50, 95% CI 0.38-0.66）。
Pooled data from 9,676 people who caught colds while taking the vitamin prophylactically did find that vitamin C reduced the duration of sneezing, congestion, and other cold symptoms by about 8% in adults (95% CI 3% to 13%) and by 13.6% in children (95% CI 5% to 22%).
9676名预防性服用维生素的人患感冒时的混合数据显示，维生素C确实可以减少喷嚏、鼻塞及其他感冒症状的持续时间，成人约减少8%（95% CI 3% -13%）儿童减少13.6% (95% CI 5% -22%)。
Trials of high dose vitamin C initiated at the first signs of a cold demonstrated no consistent effect on either duration or severity of symptoms, but, Dr. Hemilä said, there were few such trials in the literature and "their quality was variable."
在感冒开始时服用高剂量维生素C的试验显示，不管是对症状持续时间还是对症状严重程度都没有相应的改善作用，但Hemilä博士说，该论文中的这类试验很少，而且“质量也是可变的”。
Vitamin C has steadily gained status as a cold remedy since its discovery in the 1930s, but the mega-vitamin C movement took off in the 1970s when Nobel Prize-winning chemist Linus Pauling published his book, Vitamin C and the Common Cold. Pauling encouraged people to take 1,000 mg of vitamin C daily.
从20世纪30年代发现维生素C开始，它就已经作为感冒药获得了稳固地位，当20世纪70年代诺贝尔奖获得者化学家Linus Pauling出版了一本名为《Vitamin C and the Common Cold》（《维生素C和普通感冒》）的书后，大剂量维生素C突然大受欢迎。Pauling鼓励人们每天服用1000mg维生素C。
The first Cochrane Review of prophylactic vitamin C was published in 1998. That review was updated in 2004 and this latest update includes a single new study but no change in the Cochrane take on vitamin C.
1998年发表了预防性服用维生素C的首次Cochrane评价。该评价于2004年更新，这份最近的更新包括一项新研究，但是对维生素C的Cochrane评价并没有改变。
Dr. Hemilä said he sees little use in further study of the vitamin in colds for adults. However, he would like to see more studies on vitamin C and colds in children and vitamin C and pneumonia.
Hemilä博士说，他觉得进一步研究维生素对成人感冒的作用意义不大。然而，他希望看到更多关于维生素C与儿童感冒及维生素C与肺炎的研究。
Vitamin C, he said in a statement, is not a panacea, but it is not useless either. "Pauling was overly optimistic, but he wasn't completely wrong."
他声称，维生素C不是一种万能药，但也并非毫无用处。“Pauling过分乐观，但并非完全错误。”
Dr. Hemilä disclosed no conflicts. The Commonwealth Department of Health and Aging and the Australian National University funded the study.
Hemilä博士透露前后研究并没有矛盾。联邦政府健康与高龄事务厅及澳大利亚国立大学资助该项研究。
Additional Preventive Care Coverage
另外的预防保健范围
Primary source: Cochrane Collaboration Cochrane Library
Source reference:
Douglas R.M. "Vitamin C for Preventing and Treating the Common Cold (Review)" Cochrane Database of Systematic Reviews 2007; Issue 3 Published online July 18, 2007 DOI: 10.1002/14651858.CD00980.pub3
最初来源：Cochrane 协作网Cochrane 图书馆
参考文献：
Douglas R.M. "维生素C预防和治疗普通感冒 (综述)" Cochrane 系统评价数据库2007; 第 3期 2007年7月18日在线发表 , DOI: 10.1002/14651858.CD00980.pub3

2007-07-20 16:04

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ginnyran 编辑于 2007-07-26 14:43

• 12 月首批博士招聘计划：20 省市 65 家单位高薪诚聘博士及博士后

ginnyran

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编译：（中文字符：560）

http://www.medpagetoday.com/PrimaryCare/PreventiveCare/tb/6186

维生素C并不能预防大部分成年人感冒

据www.medpagetoday.com 7月18日新闻报道，在线发表在The Cochrane Library第3期上的一项关于维生素C的最新综述称，虽然对于大部分人而言，维生素C不能预防感冒，但对于马拉松运动员来说，如果每天服用200mg以上维生素C可以使感冒风险降低50%。

该综述合作者赫尔辛基大学的Harri Hemilä医学博士称，30项试验研究的11350多名参与者的综合数据显示，预防性服用维生素C，患感冒的相对危险度为0.96（0.92-1.00），这说明没有必要为了减少感冒而一年365天每天服用维生素C。但包括642名长跑运动员、滑雪者及部署在亚北极地区士兵的6项试验数据显示，补充维生素C可以使这类人群的感冒风险减半（RR 0.50, 95% CI 0.38-0.66）。9676名预防性服用维生素的人感冒综合数据显示，维生素C确实可以减少喷嚏、鼻塞及其他感冒症状的持续时间，成人约减少8%（95% CI 3% -13%），儿童减少13.6% (95% CI 5% -22%)。但研究显示，感冒开始时服用高剂量维生素C，不管是对症状持续时间还是对症状严重程度都没有相应的改善作用，不过Hemilä博士认为这类试验比较少并不足信。

从20世纪30年代发现维生素C开始，它就已经作为感冒药获得了稳固地位，当20世纪70年代诺贝尔奖获得者Linus Pauling出版了一本名为《Vitamin C and the Common Cold》的书后，大剂量维生素C突然大受欢迎。Pauling鼓励人们每天服用1000mg维生素C。1998年发表了关于预防性服用维生素C的首次Cochrane评价，该评价于2004年进行更新，其包括一项新研究，但对维生素C的Cochrane评价结果并没有改变。Hemilä博士觉得进一步研究维生素对成人感冒的作用意义不大。然而，他希望看到更多关于维生素C与儿童感冒及维生素C与肺炎的研究。他声称维生素C不是一种万能药，但也并非毫无用处。（丁香）

2007-07-20 16:26

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ginnyran 编辑于 2007-07-21 10:28

• 12 月首批公立医院发布招聘计划，含编制岗位

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