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【bio-news】2007年终中国高影响因子科技论文盘点

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这个帖子发布于13年零29天前，其中的信息可能已发生改变或有所发展。

一篇高影响因子的文章可能并不代表全部，但至少给了我们发奋的理由。

在影响因子（2006）大于30的杂志上发表的文章：

1: N Engl J Med. 2007 Dec 20;357(25):2576-88.

Telbivudine versus lamivudine in patients with chronic hepatitis B.

Lai CL, Gane E, Liaw YF, Hsu CW, Thongsawat S, Wang Y, Chen Y, Heathcote EJ, Rasenack J, Bzowej N, Naoumov NV, Di Bisceglie AM, Zeuzem S, Moon YM, Goodman Z, Chao G, Constance BF, Brown NA; Globe Study Group.

University Department of Medicine, Queen Mary Hospital, Hong Kong, China. 香港玛丽医院

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2: Science. 2007 Dec 14;318(5857):1769-72.

Asymmetric mating interactions drive widespread invasion and displacement in a whitefly.

Liu SS, De Barro PJ, Xu J, Luan JB, Zang LS, Ruan YM, Wan FH.

Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China. 浙江大学

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3: N Engl J Med. 2007 Nov 1;357(18):1855.

Images in clinical medicine. Herpes labialis.（个案报道）

Tang JW, Chan PK.

Chinese University of Hong Kong, Hong Kong, China. 香港中文大学

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4: Science. 2007 Nov 2;318(5851):746.

Comment on "A vestige of Earth's oldest ophiolite".（评论）

Nutman AP, Friend CR.

Institute of Geology, Chinese Academy of Geological Sciences, 26 Baiwanzhuang Road, Beijing 100037, China. 中科院地质研究所

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5: Science. 2007 Aug 24;317(5841):1061-4.

Breakdown of the Born-Oppenheimer approximation in the F+ o-D2 -> DF + D reaction.

Che L, Ren Z, Wang X, Dong W, Dai D, Wang X, Zhang DH, Yang X, Sheng L, Li G, Werner HJ, Lique F, Alexander MH.

State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, People's Republic of (P. R.) China.中科院大连化学物理研究所

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6: Science. 2007 Aug 17;317(5840):953-7.

Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.

Hu J, Zhong C, Ding C, Chi Q, Walz A, Mombaerts P, Matsunami H, Luo M.

National Institute of Biological Sciences, Beijing, 102206, China.北京生命科学研究所

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7: Science. 2007 Jun 29;316(5833):1901-4.

Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila.

Zhang K, Guo JZ, Peng Y, Xi W, Guo A.

Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), 320 Yueyang Road, Shanghai 200031, China.中科院上海生命科学院

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8: Science. 2007 Jun 1;316(5829):1298-301.

Large-scale spatial-transmission models of infectious disease.

Riley S.

Department of Community Medicine and School of Public Health, Faculty of Medicine, University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China. 香港大学
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9: Science. 2007 May 4;316(5825):732-5.

Synthesis of tetrahexahedral platinum nanocrystals with high-index facets and high electro-oxidation activity.

Tian N, Zhou ZY, Sun SG, Ding Y, Wang ZL.

State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.厦门大学

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10: Science. 2007 May 4;316(5825):700-1.

Plant science. Signaling to the nucleus with a loaded GUN.（评论）

Zhang DP.

State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, 100094 Beijing, China. 中国农业大学
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11: N Engl J Med. 2007 Apr 19;356(16):1631-40.

Omeprazole before endoscopy in patients with gastrointestinal bleeding.

Lau JY, Leung WK, Wu JC, Chan FK, Wong VW, Chiu PW, Lee VW, Lee KK, Cheung FK, Siu P, Ng EK, Sung JJ.

Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, China. 香港中文大学

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12: Science. 2007 Mar 9;315(5817):1385-8.

Super plastic bulk metallic glasses at room temperature.

Liu YH, Wang G, Wang RJ, Zhao de Q, Pan MX, Wang WH.

Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China.中科院物理研究所

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13: Science. 2007 Mar 23;315(5819):1712-6.

A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid.

Liu X, Yue Y, Li B, Nie Y, Li W, Wu WH, Ma L.

National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.北京生命科学研究所

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14: Science. 2007 Feb 16;315(5814):1000-3.

The phosphothreonine lyase activity of a bacterial type III effector family.

Li H, Xu H, Zhou Y, Zhang J, Long C, Li S, Chen S, Zhou JM, Shao F.

National Institute of Biological Sciences, Beijing, 102206, China.北京生命科学研究所

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2007-12-25 09:42 浏览 : 9190 回复 : 6

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kangfb 编辑于 2007-12-25 13:20

• 教育部：今年国家定向培养免费医学生，你会报考吗？——回帖

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在影响因子（2006）20～30的杂志上发表的文章：

1: Cell. 2007 Dec 14;131(6):1109-23.

let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells.

Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E.

Department of Breast Surgery, No. 2 Affiliated Hospital, Sun-Yat-Sen University, Guangzhou 510120, People's Republic of China.

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2: Nature. 2007 Nov 15;450(7168):E7-8; discussion E8-9.(Comment)

Anti-correlation of summer/winter monsoons?

Zhang D, Lu L.

National Climate Centre, China Meteorological Administration, Beijing 100081, China.

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3: Nature. 2007 Nov 15;450(7168):E10-1; discussion E11.(Comment)

Record of winter monsoon strength.

Zhou H, Guan H, Chi B.

Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. hyzhou@gig.ac.cn

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4: Nat Biotechnol. 2007 Dec;25(12):1455-6.

A scorpion neurotoxin increases the potency of a fungal insecticide.

Wang C, St Leger RJ.

Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.

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5: Nat Biotechnol. 2007 Nov;25(11):1307-1313.

Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol.

Mao YB, Cai WJ, Wang JW, Hong GJ, Tao XY, Wang LJ, Huang YP, Chen XY.

[1] National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Institute of Plant Physiology and Ecology, Shanghai 200032, P.R. China. [2] Graduate School of Chinese Academy of Sciences, 300 Fenglin Road, Institute of Plant Physiology and Ecology, Shanghai 200032, P.R. China.

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6: Cell. 2007 Nov 2;131(3):441-3.(Comment)

Allosteric activation of a bacterial stress sensor.

Yan N, Shi Y.

Center for Structural Biology, Institute of Biomedicine, Tsinghua University, Beijing, China.

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7: JAMA. 2007 Oct 24;298(16):1928-30.

Factors contributing to high costs and inequality in China's health care system.

Wang H, Xu T, Xu J.

Department of Emergency Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China.

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8: Nature. 2007 Oct 4;449(7162):595-8.

An epipodite-bearing crown-group crustacean from the Lower Cambrian.

Zhang XG, Siveter DJ, Waloszek D, Maas A.

Key Laboratory for Palaeobiology, Yunnan University, Kunming 650091, China.

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9: Lancet. 2007 Sep 29;370(9593):1137-45.

H5N1 infection of the respiratory tract and beyond: a molecular pathology study.

Gu J, Xie Z, Gao Z, Liu J, Korteweg C, Ye J, Lau LT, Lu J, Gao Z, Zhang B, McNutt MA, Lu M, Anderson VM, Gong E, Yu AC, Lipkin WI.

Infectious Disease Centre, Peking University, Beijing, China.

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10: Lancet. 2007 Sep 29;370(9593):1106-8.(Comment)

Pathology of human H5N1 infection: new findings.

Ng WF, To KF.

Department of Pathology, Princess Margaret Hospital, Hong Kong, China.

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11: JAMA. 2007 Sep 26;298(12):1412-9.

Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease.

Chan AO, Jim MH, Lam KF, Morris JS, Siu DC, Tong T, Ng FH, Wong SY, Hui WM, Chan CK, Lai KC, Cheung TK, Chan P, Wong G, Yuen MF, Lau YK, Lee S, Szeto ML, Wong BC, Lam SK.

Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

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12: Nat Med. 2007 Oct;13(10):1248-52.

Adaptive immune cells temper initial innate responses.

Kim KD, Zhao J, Auh S, Yang X, Du P, Tang H, Fu YX.

Center for Infection and Immunity and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Da Tun Road, Chaoyang District, Beijing 100101, China.

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13: Endocr Rev. 2007 Oct;28(6):653-63. Epub 2007 Sep 18.

SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins.

Leung YM, Kwan EP, Ng B, Kang Y, Gaisano HY.

Departmnet of Physiology, China Medical University, Taichung 40402, Taiwan.

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14: Lancet. 2007 Aug 18;370(9587):548-9.

Disability and human rights.

Mercer SW, MacDonald R.

School of Public Health, Chinese University of Hong Kong, Hong Kong SAR, China.

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15: Nature. 2007 Sep 13;449(7159):243-7.

The structural basis for activation of plant immunity by bacterial effector protein AvrPto.

Xing W, Zou Y, Liu Q, Liu J, Luo X, Huang Q, Chen S, Zhu L, Bi R, Hao Q, Wu JW, Zhou JM, Chai J.

National Institute of Biological Sciences, No. 7 Science Park Road, Beijing 102206, China.

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16: Nat Biotechnol. 2007 Aug;25(8):921-9.

Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting.

Qiu XQ, Wang H, Cai B, Wang LL, Yue ST.

Key Laboratory of Transplant Immunology, Ministry of Health, State Key Laboratory of Biotherapy, No. 37 Wai Nan Guo-xue-Xiang, Chengdu, P.R. of China 610041.

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17: Lancet. 2007 Jul 28;370(9584):360.

Myocardial infarction in a woman with no apparent risk factors.

Rongjing D, Kun X.

Cardiology Department, Zhongsan Hospital, Dalian University, Dalian, China.

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18: Nat Immunol. 2007 Aug;8(8):882-92.

P-selectin primes leukocyte integrin activation during inflammation.

Wang HB, Wang JT, Zhang L, Geng ZH, Xu WL, Xu T, Huo Y, Zhu X, Plow EF, Chen M, Geng JG.

Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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19: Nat Immunol. 2007 Aug;8(8):817-24.

Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1.

Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G.

Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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20: Cell. 2007 Jun 29;129(7):1255-7.(Comment)

The primary cilium: keeper of the key to cell division.

Pan J, Snell W.

Department of Biological Sciences and Technologies, Tsinghua University, Haidian District, Beijing, 100084, China.

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21: Chem Rev. 2007 Jul;107(7):2821-60.

On the controllable soft-templating approach to mesoporous silicates.

Wan Y, Zhao D.

Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Key Laboratory of Molecular Engineering of Polymers, and Advanced Materials Laboratory, Fudan University, Shanghai 200433, P. R. China.

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22: Nature. 2007 Jun 14;447(7146):844-7.

A gigantic bird-like dinosaur from the Late Cretaceous of China.

Xu X, Tan Q, Wang J, Zhao X, Tan L.

Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.

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23: Lancet. 2007 May 12;369(9573):1621-6.

Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial.

Chan FK, Wong VW, Suen BY, Wu JC, Ching JY, Hung LC, Hui AJ, Leung VK, Lee VW, Lai LH, Wong GL, Chow DK, To KF, Leung WK, Chiu PW, Lee YT, Lau JY, Chan HL, Ng EK, Sung JJ.

Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

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24: Lancet. 2007 May 12;369(9573):1582-3.

Hepatitis B in China.

Liu J, Fan D.

Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi, China.

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25: Endocr Rev. 2007 Jun;28(4):440-61.

Gonadotropins and ovarian cancer.

Choi JH, Wong AS, Huang HF, Leung PC.

Department of Obstetrics and Gynecology, Zhejiang University School of Medicine, China.

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26: Nat Genet. 2007 May;39(5):605-13. Epub 2007 Apr 22.

A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.

Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q, Zeng C, Lin D.

Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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27: Cell. 2007 Apr 20;129(2):385-95.

Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2.

Guan CB, Xu HT, Jin M, Yuan XB, Poo MM.

Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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28: Chem Rev. 2007 May;107(5):1777-830.

Natural products with maleic anhydride structure: nonadrides, tautomycin, chaetomellic anhydride, and other compounds.

Chen X, Zheng Y, Shen Y.

Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China.

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29: Nat Genet. 2007 May;39(5):623-30. Epub 2007 Apr 8.

A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase.

Song XJ, Huang W, Shi M, Zhu MZ, Lin HX.

National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, The Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China.

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30: Nature. 2007 Apr 5;446(7136):661-3.

Doushantuo embryos preserved inside diapause egg cysts.

Yin L, Zhu M, Knoll AH, Yuan X, Zhang J, Hu J.

State Key Laboratory of Paleobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China.

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31: Nat Med. 2007 Apr;13(4):486-91.

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2.

Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B, Zhang Y, Xu C, Bai Y, Wang H, Chen G, Wang Z.

Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang 150086, China.

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32: Lancet. 2007 Mar 24;369(9566):993-9.

Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study.

Ruan D, He Q, Ding Y, Hou L, Li J, Luk KD.

Department of Orthopedic Surgery, The Navy General Hospital, Beijing, China.

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33: Chem Rev. 2007 Mar;107(3):748-66.

What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: an update.

Cheng Z, Li Y.

The Key Laboratory of Bioorganic & Molecular Engineering, College of Chemistry & Molecular Engineering, Peking University, Beijing, China 100871.

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34: Lancet. 2007 Feb 24;369(9562):691-6.

Progress in tuberculosis control and the evolving public-health system in China.

Wang L, Liu J, Chin DP.

Ministry of Health, Beijing, China.

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35: Lancet. 2007 Feb 24;369(9562):679-90.

Evolution of China's response to HIV/AIDS.

Wu Z, Sullivan SG, Wang Y, Rotheram-Borus MJ, Detels R.

National Centre for AIDS/STD Control and Prevention, Beijing, China.

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36: Lancet. 2007 Feb 17;369(9561):614.

Small bowel enteropathy associated with chronic low-dose aspirin therapy.

Leung WK, Bjarnason I, Wong VW, Sung JJ, Chan FK.

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37: Lancet. 2007 Jan 13;369(9556):132-8.

Syphilis in China: results of a national surveillance programme.

Chen ZQ, Zhang GC, Gong XD, Lin C, Gao X, Liang GJ, Yue XL, Chen XS, Cohen MS.

National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, 12 Jiangwangmiao Street, Nanjing 210042, China.

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38: Chem Rev. 2007 Jan;107(1):274-302.

Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders.

Zhang A, Neumeyer JL, Baldessarini RJ.

Bioorganic and Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

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39: Nat Med. 2007 Feb;13(2):147-9. Epub 2007 Jan 7.

Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract.

Nicholls JM, Chan MC, Chan WY, Wong HK, Cheung CY, Kwong DL, Wong MP, Chui WH, Poon LL, Tsao SW, Guan Y, Peiris JS.

Department of Pathology, University of Hong Kong, Pok Fu Lam Road, Hong Kong SAR, China.

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40: Nat Med. 2007 Feb;13(2):218-23.

Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection.

Lo YM, Tsui NB, Chiu RW, Lau TK, Leung TN, Heung MM, Gerovassili A, Jin Y, Nicolaides KH, Cantor CR, Ding C.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

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41: Nat Med. 2007 Jan;13(1):78-83.

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.

Liu TX, Becker MW, Jelinek J, Wu WS, Deng M, Mikhalkevich N, Hsu K, Bloomfield CD, Stone RM, DeAngelo DJ, Galinsky IA, Issa JP, Clarke MF, Look AT.

Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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42: Nat Rev Genet. 2007 Jan;8(1):71-7.

Prenatal diagnosis: progress through plasma nucleic acids.

Dennis Lo YM, Chiu RW.

Li Ka Shing Institute of Health Sciences and the Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 3032 Ngan Shing Street, Shatin, New Territories, Hong Kong SAR, China.

2007-12-25 13:18

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kangfb 编辑于 2007-12-25 13:22

• 病史长达15年的老烂腿，多家医院诊疗无果，疼痛难忍……

楼主

kangfb

肝病科

丁香园准中级站友

3楼

在影响因子（2006）15～20的杂志上发表的文章：

1: J Clin Invest. 2007 Dec 13

Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke.

Shyu WC, Lin SZ, Chiang MF, Chen DC, Su CY, Wang HJ, Liu RS, Tsai CH, Li H.

Center for Neuropsychiatry, China Medical University and Hospital, Taichung, Republic of China. Department of Neurosurgery, Mackay Memorial Hospital, Mackay Junior College of Nursing, Taipei, Republic of China. Department of Neurosurgery, Buddhist Tzu-Chi General Hospital, Tzu-Chi University, Hualien, Republic of China. Institute of Molecular Biology, Academia Sinica, Taipei, Republic of China. Department of Nuclear Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Republic of China. Department of Pediatrics, China Medical University and Hospital, Taichung, Republic of China.

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2: J Clin Invest. 2007 Dec 3;117(12):4022-4033.

Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.

Rao Y, Liu ZW, Borok E, Rabenstein RL, Shanabrough M, Lu M, Picciotto MR, Horvath TL, Gao XB.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA. Department of Neurobiology, Yunyang Medical College, Shiyan, Hubei, People’s Republic of China. Department of Psychiatry, Department of Neurobiology, and Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

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3: J Clin Invest. 2007 Dec 3;117(12):3673-3683.

Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium.

Bu HF, Zuo XL, Wang X, Ensslin MA, Koti V, Hsueh W, Raymond AS, Shur BD, Tan XD.

Molecular and Cellular Pathobiology Program and Center for Digestive Disease and Immunobiology, Children’s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Department of Gastroenterology, Qilu Hospital, Medical College of Shandong University, Jinan, Shandong, People’s Republic of China. Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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4: Nat Cell Biol. 2007 Dec;9(12):1436-41.

Telomere lengthening early in development.

Liu L, Bailey SM, Okuka M, Muñoz P, Li C, Zhou L, Wu C, Czerwiec E, Sandler L, Seyfang A, Blasco MA, Keefe DL.

[1] Laboratory for Reproductive Medicine, Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida 33612, USA. [2] College of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.

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5: J Natl Cancer Inst. 2007 Oct 17;99(20):1551-5.

Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8.

Duan HF, Hu XW, Chen JL, Gao LH, Xi YY, Lu Y, Li JF, Zhao SR, Xu JJ, Chen HP, Chen W, Wu CT.

Beijing Institute of Radiation Medicine, Haidian District, Beijing, China.

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6: Cell Metab. 2007 Oct;6(4):307-19.

SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.

Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, Zhai Q.

Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.

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7: Nat Mater. 2007 Oct;6(10):744-8.

Negative birefraction of acoustic waves in a sonic crystal.

Lu MH, Zhang C, Feng L, Zhao J, Chen YF, Mao YW, Zi J, Zhu YY, Zhu SN, Ming NB.

National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, People's Republic of China.

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8: Nat Mater. 2007 Oct;6(10):735-9.

Tensile ductility and necking of metallic glass.

Guo H, Yan PF, Wang YB, Tan J, Zhang ZF, Sui ML, Ma E.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.

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9: J Natl Cancer Inst. 2007 Aug 15;99(16):1240-7.

Chemoprevention of primary liver cancer: a randomized, double-blind trial in Linxian, China.

Qu CX, Kamangar F, Fan JH, Yu B, Sun XD, Taylor PR, Chen BE, Abnet CC, Qiao YL, Mark SD, Dawsey SM.

Cancer Institute, Chinese Academy of Medical Sciences, Beijing, China.

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10: Cell Metab. 2007 Aug;6(2):115-28.

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase.

Cao J, Wang J, Qi W, Miao HH, Wang J, Ge L, DeBose-Boyd RA, Tang JJ, Li BL, Song BL.

State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.

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11: Nat Cell Biol. 2007 Aug;9(8):945-53.

Regulated ATP release from astrocytes through lysosome exocytosis.

Zhang Z, Chen G, Zhou W, Song A, Xu T, Luo Q, Wang W, Gu XS, Duan S.

Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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12: J Natl Cancer Inst. 2007 Jul 4;99(13):1004-15.

Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.

Tang N, Du G, Wang N, Liu C, Hang H, Liang W.

Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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13: J Natl Cancer Inst. 2007 Jun 20;99(12):936-48.

Cell cycle-related kinase: a novel candidate oncogene in human glioblastoma.

Ng SS, Cheung YT, An XM, Chen YC, Li M, Li GH, Cheung W, Sze J, Lai L, Peng Y, Xia HH, Wong BC, Leung SY, Xie D, He ML, Kung HF, Lin MC.

Department of Chemistry, Open Laboratory of Chemical Biology, The University of Hong Kong, Pokf***, Hong Kong, China.

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14: Nat Cell Biol. 2007 Jul;9(7):743-54. Epub 2007 Jun 10.

Dishevelled promotes axon differentiation by regulating atypical protein kinase C.

Zhang X, Zhu J, Yang GY, Wang QJ, Qian L, Chen YM, Chen F, Tao Y, Hu HS, Wang T, Luo ZG.

Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.

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15: Nat Mater. 2007 Jul;6(7):507-11.

Enhanced ethanol production inside carbon-nanotube reactors containing catalytic particles.

Pan X, Fan Z, Chen W, Ding Y, Luo H, Bao X.

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, PR China.

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16: Acc Chem Res. 2007 Aug;40(8):635-43. Epub 2007 May 12.

Interface-mediated growth of monodispersed nanostructures.

Wang X, Peng Q, Li Y.

Department of Chemistry, Tsinghua University, Beijing 100084, China.

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17: Nat Mater. 2007 Jul;6(7):521-7.

Metallated conjugated polymers as a new avenue towards high-efficiency polymer solar cells.

Wong WY, Wang XZ, He Z, Djurisić AB, Yip CT, Cheung KY, Wang H, Mak CS, Chan WK.

Department of Chemistry, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, PR China.

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18: J Clin Invest. 2007 May;117(5):1175-83.

A cytokine-mediated link between innate immunity, inflammation, and cancer.

Lin WW, Karin M.

Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Republic of China.

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19: Genes Dev. 2007 May 15;21(10):1190-203. Epub 2007 Apr 30.

A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii.

Zhao T, Li G, Mi S, Li S, Hannon GJ, Wang XJ, Qi Y.

National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing 102206, China.

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20: J Clin Invest. 2007 Apr;117(4):871-3.(comment)

Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease.

Zhang J.

Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine, and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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21: Nat Mater. 2007 Apr;6(4):283-6. Epub 2007 Mar 18.

Temperature-mediated growth of single-walled carbon-nanotube intramolecular junctions.

Yao Y, Li Q, Zhang J, Liu R, Jiao L, Zhu YT, Liu Z.

State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Key Laboratory for the Physics and Chemistry of Nanodevices, College of Chemistry and Molecular Engineering, Peking University, China.

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22: Acc Chem Res. 2007 Apr;40(4):267-74.

Bioinorganic chemistry of bismuth and antimony: target sites of metallodrugs.

Ge R, Sun H.

Department of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Pokf***, Hong Kong, PR China.

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23: Acc Chem Res. 2007 Feb;40(2):162-70.

Solvothermal in situ metal/ligand reactions: a new bridge between coordination chemistry and organic synthetic chemistry.

Chen XM, Tong ML.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.

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24: J Clin Invest. 2007 Mar;117(3):730-8.

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.

Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ.

Department of Physiology, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

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25: Cell Metab. 2007 Jan;5(1):47-57.

Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.

Bai L, Wang Y, Fan J, Chen Y, Ji W, Qu A, Xu P, James DE, Xu T.

Joint Laboratory of Institute of Biophysics and Huazhong University of Science and Technology, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

2007-12-25 13:29

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• 博士第三年，遇到极大的困难，不知道该如何走下去

yunxiang

分子生物学实验室

丁香园准中级站友

4楼

1: N Engl J Med. 2007 Dec 20;357(25):2576-88.

Telbivudine versus lamivudine in patients with chronic hepatitis B.

Lai CL, Gane E, Liaw YF, Hsu CW, Thongsawat S, Wang Y, Chen Y, Heathcote EJ, Rasenack J, Bzowej N, Naoumov NV, Di Bisceglie AM, Zeuzem S, Moon YM, Goodman Z, Chao G, Constance BF, Brown NA; Globe Study Group.

University Department of Medicine, Queen Mary Hospital, Hong Kong, China. 香港玛丽医院

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2: Science. 2007 Dec 14;318(5857):1769-72.

Asymmetric mating interactions drive widespread invasion and displacement in a whitefly.

Liu SS, De Barro PJ, Xu J, Luan JB, Zang LS, Ruan YM, Wan FH.

Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China. 浙江大学

http://www.dxy.cn/bbs/thread/10396623
热烈祝贺农学院昆虫科学研究所刘树生教授论文在SCIENCE上发表并举办新闻发布会

来源：农学院作者：admin 更新日期：2007-11-9 阅读次数：530

11月8日，由我校昆虫科学研究所刘树生教授作为第一作者兼通讯作者的学术论文《非对称交配互作驱动一种粉虱的广泛入侵及对土著生物的取代》在《SCIENCE》上发表，该杂志已于8日在北京举办新闻发布会。

B 型烟粉虱是全球100种最危险入侵生物之一，包括许多不同的遗传群或“生物型”，可能起源于地中海—小亚细亚地区，并且传播到世界大多数地方，被认为是世界上危害性最大的农业害虫。90年代初期入侵到澳大利亚，90年代中期入侵到中国。B型烟粉虱入侵后，种群迅速增长并扩张，有时候，一片棉花叶上会有上万只B型烟粉虱。这些害虫大量取食，危害番茄、烟草、棉花等数十种重要经济作物，传播双生病毒引发植物病毒病蔓延成灾，取代危害性不大的土著烟粉虱导致本地生物灭绝，所到之处农作物严重减产甚至绝收，被国际科技界称为“超级害虫”。目前正给中国的农业和环境造成很严重的破坏。

为了探索其“超级入侵”本能的奥秘，世界各国的科学家进行了长期的努力，但一直都没有找到答案。

刘树生教授领衔的科研团队于1995年-2006年间在中国浙江、澳大利亚昆士兰共40多个地点进行野外系统采样调查。通过长期研究课题组发现，B型烟粉虱之所以能让成片的农作物绝收，因为它有两大“武器”：一方面利用交配行为入侵，让土著烟粉虱绝种；另一方面与病毒强强联合，既加快自身的繁殖，又加速植物病毒病的流行。 “非对称交配互作”是B型烟粉虱入侵的一个关键机制，它在促进B型烟粉虱数量增长的同时压抑土著烟粉虱种群增长，促进B型烟粉虱迅速入侵和扩张，取代危害性不大的土著烟粉虱。B型烟粉虱与它所传播的植物双生病毒(对植物危害最严重的一类病毒)之间存在互利共生关系，这种关系既有利于B型烟粉虱的繁殖入侵，又加速了病毒病的流行，经B型烟粉虱传播后，植物双生病毒的“毒性”也越来越强。这项由浙江大学昆虫科学研究所、中国农业科学院植物保护研究所与澳大利亚同行合作的研究成果，揭示了B型烟粉虱产生强大入侵能力的行为机制。

《科学》杂志论文评审专家在阅读了刘树生等投寄的论文后，对其做了高度评价。他们认为，这一研究综合应用生态学、行为学、分子生物学等领域的方法，将广泛系统的野外调查、巧妙的实验种群试验和独特且详细的行为观察有机地结合应用，而且研究在位于中国和澳大利亚的两个地理区同时进行，设计之巧妙，数据之系统和完整，在入侵生物学研究领域实属罕见，所做的结论令人信服。他们指出，该研究是入侵生物学领域的开拓性工作，将对这一学科的发展起到显著的推动作用，同时昆虫学、农学、动物行为学、进化生物学等学科领域也会从中得到启迪。美国、英国、德国等世界各国的媒体记者近几天纷纷通过各种方式采访刘树生教授。（农学院）
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3: N Engl J Med. 2007 Nov 1;357(18):1855.

Images in clinical medicine. Herpes labialis.（个案报道）

Tang JW, Chan PK.

Chinese University of Hong Kong, Hong Kong, China. 香港中文大学

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4: Science. 2007 Nov 2;318(5851):746.

Comment on "A vestige of Earth's oldest ophiolite".（评论）

Nutman AP, Friend CR.

Institute of Geology, Chinese Academy of Geological Sciences, 26 Baiwanzhuang Road, Beijing 100037, China. 中科院地质研究所

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5: Science. 2007 Aug 24;317(5841):1061-4.

Breakdown of the Born-Oppenheimer approximation in the F+ o-D2 -> DF + D reaction.

Che L, Ren Z, Wang X, Dong W, Dai D, Wang X, Zhang DH, Yang X, Sheng L, Li G, Werner HJ, Lique F, Alexander MH.

State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, People's Republic of (P. R.) China.中科院大连化学物理研究所

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6: Science. 2007 Aug 17;317(5840):953-7.

Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.

Hu J, Zhong C, Ding C, Chi Q, Walz A, Mombaerts P, Matsunami H, Luo M.

National Institute of Biological Sciences, Beijing, 102206, China.北京生命科学研究所
研究人员发现了小鼠的一组嗅觉神经元，它们使小鼠能够检测到与普通空气中浓度相当的二氧化碳量。非脊椎动物比如昆虫对二氧化碳有很强的嗅觉，它们靠二氧化碳气味微小的变化来找食物或配偶。但是包括人类在内的哺乳类动物看起来只有在高浓度下才能捕捉到二氧化碳的气味。Ji Hu和同事现在揭示，小鼠用嗅觉神经元的一组特殊的感受二氧化碳的酶在接近大气中的浓度下检测该气体。文章作者提出，小鼠和其它可能由这些气味感受器的哺乳动物，随着全球大气中二氧化碳浓度的增加，可能会有生态和行为的变化。
英文摘要：Detection of Near-Atmospheric Concentrations of CO2 by an Olfactory Subsystem in the Mouse,Ji Hu, Chun Zhong, Cheng Ding, Qiuyi Chi, Andreas Walz, Peter Mombaerts,et al.
http://www.dxy.cn/bbs/post/view?bid=116&id=9816065&sty=3&keywords=8%D4%C2
Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.
Hu J, Zhong C, Ding C, Chi Q, Walz A, Mombaerts P, Matsunami H, Luo M.

National Institute of Biological Sciences, Beijing, 102206, China.

Carbon dioxide (CO2) is an important environmental cue for many organisms but is odorless to humans. It remains unclear whether the mammalian olfactory system can detect CO2 at concentrations around the average atmospheric level (0.038%). We demonstrated the expression of carbonic anhydrase type II (CAII), an enzyme that catabolizes CO2, in a subset of mouse olfactory neurons that express guanylyl cyclase D (GC-D+ neurons) and project axons to necklace glomeruli in the olfactory bulb. Exposure to CO2 activated these GC-D+ neurons, and exposure of a mouse to CO2 activated bulbar neurons associated with necklace glomeruli. Behavioral tests revealed CO2 detection thresholds of approximately 0.066%, and this sensitive CO2 detection required CAII activity. We conclude that mice detect CO2 at near-atmospheric concentrations through the olfactory subsystem of GC-D+ neurons.
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7: Science. 2007 Jun 29;316(5833):1901-4.

Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila.

Zhang K, Guo JZ, Peng Y, Xi W, Guo A.

Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), 320 Yueyang Road, Shanghai 200031, China.中科院上海生命科学院

果蝇如何做决定[To top]

研究显示当果蝇做出基于价值的决定时，它们使用一个两个阶段的系统。研究人员对了解灵长类如何做决定很感兴趣，但是灵长类的大脑太复杂了，于是张柯以及一组中国神经科学家用了一个更简单的系统。张和同事选择用果蝇Drosophila melanogaster来研究如何做决定。他们训练了这些果蝇在一个模拟飞行器中训练响应颜色和位置的信号。当果蝇需要做一个价值选择时，它们先靠一种被称为“形成(formation)”的非线性过程，将大脑的涉及认知和运动的多巴胺系统与一个涉及学习与记忆的名为蘑菇体的结构结合起来。然后大脑进入一个更简单的、基于感知的被称为“执行(execution)”独立于多巴胺系统和蘑菇体的线性阶段。
英文摘要：Dopamine- Mushroom Body Circuit Regulates Saliency-Based Decision Making in Drosophila, Ke Zhang, Jian Zeng Guo, Yueqing Peng, Wang Xi, and Aike Guo

Science 29 June 2007:
Vol. 316. no. 5833, pp. 1901 - 1904
DOI: 10.1126/science.1137357
Prev | Table of Contents | Next

Reports
Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila
Ke Zhang,1,2 Jian Zeng Guo,1 Yueqing Peng,1,2 Wang Xi,1,2 Aike Guo1,3*
Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila.

1 Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), 320 Yueyang Road, Shanghai 200031, China.
2 Graduate School of Chinese Academy of Sciences, Beijing 100049, China.
3 State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, CAS, 15 Datun Road, Chaoyang District, Beijing 100101, China.
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8: Science. 2007 Jun 1;316(5829):1298-301.

Large-scale spatial-transmission models of infectious disease.

Riley S.

Department of Community Medicine and School of Public Health, Faculty of Medicine, University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China. 香港大学
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9: Science. 2007 May 4;316(5825):732-5.

Synthesis of tetrahexahedral platinum nanocrystals with high-index facets and high electro-oxidation activity.

Tian N, Zhou ZY, Sun SG, Ding Y, Wang ZL.

State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.厦门大学

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10: Science. 2007 May 4;316(5825):700-1.

Plant science. Signaling to the nucleus with a loaded GUN.（评论）

Zhang DP.

State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, 100094 Beijing, China. 中国农业大学
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11: N Engl J Med. 2007 Apr 19;356(16):1631-40.

Omeprazole before endoscopy in patients with gastrointestinal bleeding.

Lau JY, Leung WK, Wu JC, Chan FK, Wong VW, Chiu PW, Lee VW, Lee KK, Cheung FK, Siu P, Ng EK, Sung JJ.

Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, China. 香港中文大学

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12: Science. 2007 Mar 9;315(5817):1385-8.

Super plastic bulk metallic glasses at room temperature.

Liu YH, Wang G, Wang RJ, Zhao de Q, Pan MX, Wang WH.

Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China.中科院物理研究所
自中国科学院物理研究所的汪卫华研究组在非晶合金的塑性研究中取得的重要进展。他们成功研制出在室温条件下同时具有超高
塑性和超高强度的块体非晶合金材料，并对其进行了结构分析，提出了探索塑性大块非晶的新方法，在物理上证明高强度和大塑性(结构材料最重要的两个性质)在非晶材料中可以有机结合在一起。此外，该材料的组元均是价格较低廉的常见金属，结合其优良的性能，使得该非晶合金有望得到广泛的实际应用。

这一研究组几年来在非晶态合金材料的塑性变形方面做了较系统的研究，澄清了脆性材料断裂研究中一些重要科学问题，加深了对非晶态等脆性材料的断裂机制的认识【见Phys. Rev. Lett. 94, 125510(2005) 】，在此基础上提出了切变唯像模型，利用泊松比有效地标定了大部分大块非晶合金的室温塑性【见Philo. Mag. Lett. 85 (2), 77-87(2005)，, J Appl. Phys. 99, 093506(2006)】为改进非晶材料的脆性，设计新的具有大塑性、高强度的金属玻璃材料提供了必要的理论依据。并在此基础上首先开发出了具有较大塑性的CuZr基单相非晶合金材料【见Phys. Rev. Lett. 94(2005)205501】。

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13: Science. 2007 Mar 23;315(5819):1712-6.

A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid.

Liu X, Yue Y, Li B, Nie Y, Li W, Wu WH, Ma L.

National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.北京生命科学研究所
马力耕博士《SCIENCE》杂志发表论文作者: 来源:北京生命科学研究所发布者: 刘斌类别:头条新闻日期: 2007-03-12 今日/总浏览: 3/485

北京生命科学研究所马力耕博士实验室在3月8日《SCIENCE》杂志网络版上发表论文，报道一种G蛋白偶联受体是植物激素脱落酸的受体，该受体通过与异三聚体G蛋白α亚基直接相互作用传递脱落酸信号。论文的第一作者是刘西岗，其他作者还有岳艳玲、聂艳丽、李薇和中国农业大学的李斌和武维华博士，马力耕是通讯作者。

2007年3月8日，北京生命科学研究所马力耕博士实验室在科学(SCIENCE)杂志在线(online)发表题为 “A G protein-coupled receptor is a plasma membrane receptor for plant hormone abscisic acid” 的论文，该论文报道一种G蛋白偶联受体是植物激素脱落酸（Abscisic acid，ABA）的受体，该受体通过与异三聚体G蛋白α亚基直接相互作用传递脱落酸信号并调控脱落酸众多反应。

脱落酸是一种重要的植物激素，它参与调控众多植物生长和发育过程，特别是在植物对逆境，如干旱、盐碱、低温等的反应中发挥重要作用。ABA受体的研究对了解ABA的作用及其机制有非常重要的意义。以前的众多研究结果表明ABA的作用位点在质膜上，而且这种推测的质膜上的ABA受体可能是ABA参与逆境反应的主要参与者。

由G蛋白偶联受体（GPCR）介导的细胞信号转导途径是在真核生物中比较保守的信号转导机制。在动物细胞中GPCR介导的信号途径是重要的信号转导途径，比如动物对视觉、味觉、嗅觉的感知就是通过GPCR介导的信号途径实现的，动物中GPCR和G蛋白的种类也很多，它们参与的信号转导途径和生物学功能也很多。与此相反，高等植物中的GPCR和G蛋白的种类则非常有限，如模式生物拟南芥基因组中只有一种Gα，一种Gβ，2种Gγ和大约20-30种GPCR，而且到目前为止只有一种GPCR被比较详细地研究过，目前植物中还没有找到任何一种GPCR的配基。

该项工作鉴定了一种拟南芥中新的GPCR（GCR2），证实GCR2和Gα共同作用调控已知的ABA的众多反应。ABA可以与GCR2蛋白特异性的结合，而且这种结合符合配基-受体结合特性。研究人员进一步发现ABA与GCR2结合会导致GCR2-Gα蛋白复合体解离，从而释放出Gα使Gα进一步激活下游的效应器，从而证实GCR2是植物激素ABA的受体。该项工作的主要贡献有：1，鉴定确认了ABA的受体；2，明确了ABA的信号转导途径；3，发现了植物体系中的第一对配基-受体对。

该论文的第一作者是刘西岗博士，论文的其他作者还有岳艳玲、聂艳丽、李薇和中国农业大学的李斌和武维华博士。论文的通讯作者是马力耕博士。

该项研究为科技部863和北京市政府资助课题。

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14: Science. 2007 Feb 16;315(5814):1000-3.

The phosphothreonine lyase activity of a bacterial type III effector family.

Li H, Xu H, Zhou Y, Zhang J, Long C, Li S, Chen S, Zhou JM, Shao F.

National Institute of Biological Sciences, Beijing, 102206, China.北京生命科学研究所
北京生命科学研究所邵峰博士实验室在科学（Science）杂志上发表文章

2007 年2月16日，我所邵峰博士实验室在科学（Science）杂志上发表题为 “The Phosphothreonine Lyase Activity of a Bacterial Type III Effector Family” 的文章。该文章报道了来源于多种三型分泌系统致病病原菌的一个效应分子家族，这类效应分子通过一种新的磷酸化苏氨酸裂解酶（Phosphothreonine Lyase）的活性，能够特异性地、不可逆地去磷酸化宿主MAPK激酶并使其失活。

通过所谓的三型分泌系统分泌效应分子进入真核宿主体内，进而阻断或调节宿主免疫相关的信号通路是许多革蓝氏阴性病原菌普遍采用的致病机制。寻找这些效应分子在宿主细胞中的靶蛋白并阐明其作用于靶蛋白及相关信号通路的生物化学机理对于我们认识病原菌致病机理和建立有效防治手段有着重要的意义。同时，这也可能促进我们对真核细胞本身的信号转导机制的进一步理解。　在这篇文章里，作者首先发现了一类高度保守的，既存在于动物病原菌［包括导致痢疾的志贺氏痢疾杆菌（shigella）和沙门氏菌（Salmonella）］，同时也存在于能够感染植物的假单胞杆菌（Pseudomonas syringae）中的三型分泌系统效应分子。通过对其中志贺氏痢疾杆菌来源的OspF效应分子的深入研究，作者发现OspF效应分子直接作用于真核宿主体内的，并且能够抑制MAPK激酶通路的激活。进一步的生化研究发现OspF具有全新的磷酸化苏氨酸裂解酶的活性，　这种酶活能够使OspF不可逆地“去磷酸化”MAPK激酶并使之失活。作者在文章中又证明了OspF效应分子家族都普遍具有这种MAPK激酶特异性的磷酸化苏氨酸裂解酶活性并探讨了可能的催化位点。

邵峰博士（本文通讯作者）说：“我们的发现不仅揭示了一种在动植物界都保守的致病病原菌拮抗真核宿主细胞免疫信号通路的机理，但更为重要的是，这种机理是由一种全新的酶学活性来完成的，并且突破了二十多年来关于蛋白质磷酸化和去磷酸化是可逆调节的认识”。

邵峰博士于1996年毕业于北京大学，2003年获美国密执安大学博士学位， 2005年7月应聘为研究所研究员并开始筹建实验室。此项工作从起始到论文发表，全部在研究所完成。对他在如此短的时间内所获得的进展，邵峰博士指出： “研究所为大家提供了一个最佳的科研环境。”

李洪涛博士，徐浩（技术员）和周艳（本科实习生）为本文共同第一作者；其他参与此项工作的还有，张杰（在读博士生），龙承祖（技术员），李素芹（技术员），陈涉（蛋白质组中心）和周俭民博士。

此项研究为科技部863和北京市科委资助课题。

2007-12-25 14:47

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yunxiang 编辑于 2007-12-25 15:15

• 被曝欠外债20亿、欠薪1年多，全院医护第2次游行讨薪！

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