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【科普】气管支气管镜改善气管支气管软化患者症状、生活质量、肺功能、活动能力

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楼主 cxw129
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这个帖子发布于12年零148天前,其中的信息可能已发生改变或有所发展。
气管支气管镜改善气管支气管软化患者症状、生活质量、肺功能、活动能力
Tracheobronchoplasty Can Be Effective for Severe Tracheobronchomalacia
NEW YORK (Reuters Health) Nov 04 - Tracheobronchoplasty provides central airway stabilization and symptom relief in patients with severe tracheobronchomalacia (TBM), according to a report in the October issue of Chest.
"TBM is an underdiagnosed entity that can be responsible for a wide variety of pulmonary symptoms, including unexplained respiratory failure or worse than expected symptoms from emphysema," Dr. Armin Ernst from Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, told Reuters Health.
Dr. Ernst and colleagues evaluated the efficacy of surgical tracheobronchoplasty in improving symptoms, quality of life, and lung function and exercise capacity in 35 patients with severe and symptomatic TBM.
The patients had been identified as surgical candidates based on symptomatic response with temporary placement of an airway stent. The surgical procedure, following stent removal, aimed to stabilize the membranous wall of the intrathoracic trachea and mainstream bronchi.
All patients experienced improvements in the modified St. George respiratory questionnaire, the baseline dyspnea index/transitional dyspnea index, the American Thoracic Society dyspnea score, and the Karnofsky performance scale after surgery, the team reports.
Two patients who required mechanical ventilation for respiratory failure secondary to TBM were able to be weaned off ventilation after stent placement and experienced subjective and objective improvement following surgery.
Fifteen patients (43%) experienced surgical complications, including the requirement for mechanical ventilation more than 24 hours after surgery (7 patients), pneumonia/bronchitis (4), subcutaneous emphysema (4), atrial fibrillation (3), hemothorax (1), and transverse myelitis (1), and two patients (5.7%) died.
Hospital stays ranged from 3 to 90 days, with a median of 8 days, the report indicates.
"We believe that despite the limitations of our study, results are compelling and we recommend that patients with severe, diffuse, and symptomatic TBM should be evaluated in an experienced center and considered for central airway stabilization," the researchers conclude.
"Currently one should have all evaluations and interventions performed in a center experienced in the management of TBM," Dr. Ernst emphasized.
"All (our) patients are involved in a registry and are being followed on a yearly basis to better assess long term outcome," Dr. Ernst added.
Chest 2008;134:801-807.
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2008-11-16 17:11 浏览 : 1682 回复 : 5
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本人已认领该文编译,48小时后若未提交译文,请其他战友自由认领。
2008-11-22 19:21
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Tracheobronchoplasty Can Be Effective for Severe Tracheobronchomalacia
气管支气管成形术可有效治疗气管支气管软化症
NEW YORK (Reuters Health) Nov 04 - Tracheobronchoplasty provides central airway stabilization and symptom relief in patients with severe tracheobronchomalacia (TBM), according to a report in the October issue of Chest.
纽约(路透社健康报道)11月4日——根据CHEST杂志十月份的一篇报道,气管支气管成形术可以稳定中央气道并缓解气管支气管软化症(TBM)患者的症状。
"TBM is an underdiagnosed entity that can be responsible for a wide variety of pulmonary symptoms, including unexplained respiratory failure or worse than expected symptoms from emphysema," Dr. Armin Ernst from Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, told Reuters Health.
“TBM是一种诊断标准不明的疾病,它可以导致广泛的各种各样的肺部症状,包括不明原因的呼吸衰竭和比肺气肿预期症状更严重的表现。” 来自马萨诸塞州,波士顿,哈佛大学医学院,贝斯以色列女执事医疗中心的阿明•恩斯特医生告诉路透社记者。
Dr. Ernst and colleagues evaluated the efficacy of surgical tracheobronchoplasty in improving symptoms, quality of life, and lung function and exercise capacity in 35 patients with severe and symptomatic TBM.
恩斯特医生及其同事们评价了外科气管支气管成形术在改善35例严重症状性TBM患者症状、生活质量、肺功能和运动能力等方面的效果。
The patients had been identified as surgical candidates based on symptomatic response with temporary placement of an airway stent. The surgical procedure, following stent removal, aimed to stabilize the membranous wall of the intrathoracic trachea and mainstream bronchi.
根据对临时放置的气道支架的症状反应来确定患者是否行手术治疗。移除支架之后所进行的手术操作的目的是稳定胸内气管和主支气管的膜壁。
All patients experienced improvements in the modified St. George respiratory questionnaire, the baseline dyspnea index/transitional dyspnea index, the American Thoracic Society dyspnea score, and the Karnofsky performance scale after surgery, the team reports.
该团队报道,手术后所有患者在进行改良St. George呼吸问卷、基准呼吸困难指数/过渡呼吸困难指数、美国胸科学会呼吸困难评分和Karnofsky绩效评分测试时都呈现出改善表现。
Two patients who required mechanical ventilation for respiratory failure secondary to TBM were able to be weaned off ventilation after stent placement and experienced subjective and objective improvement following surgery.
两名因TBM继发呼吸衰竭而需要进行机械通气的患者在支架放置后可以脱离辅助通气,而且都在手术后表现出主观和客观的改善。
Fifteen patients (43%) experienced surgical complications, including the requirement for mechanical ventilation more than 24 hours after surgery (7 patients), pneumonia/bronchitis (4), subcutaneous emphysema (4), atrial fibrillation (3), hemothorax (1), and transverse myelitis (1), and two patients (5.7%) died.
15例患者(占43%)发生了手术并发症,包括手术后需要机械通气超过24小时 (7例)、肺炎或支气管炎(4例)、皮下气肿(4例)、心房颤动(3例)、血胸(1例)、横断性脊髓炎(1例),以及死亡两例(5.7%)。
Hospital stays ranged from 3 to 90 days, with a median of 8 days, the report indicates.
该报告指出,患者住院天数为3 〜 90天,中位数为8天。
"We believe that despite the limitations of our study, results are compelling and we recommend that patients with severe, diffuse, and symptomatic TBM should be evaluated in an experienced center and considered for central airway stabilization," the researchers conclude.
研究人员推断,“尽管我们的研究存在局限性,但我们认为结果是令人信服的,我们建议严重的弥漫的症状性TBM患者应到有经验的医学中心进行中央气道稳定性的评价。”
"Currently one should have all evaluations and interventions performed in a center experienced in the management of TBM," Dr. Ernst emphasized.
恩斯特医生强调,“目前患者应该在一个有处理TBM经验的医学中心进行所有的评价和干预治疗。”
"All (our) patients are involved in a registry and are being followed on a yearly basis to better assess long term outcome," Dr. Ernst added.
恩斯特博士补充说,“我们对所有的患者都进行了登记,并出现一年好过一年的长期评估结果。”
Chest 2008;134:801-807.
2008-11-22 21:26
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梦在远方 编辑于 2008-11-22 21:28
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气管支气管成形术可有效治疗气管支气管软化症
纽约(路透社健康报道)11月4日——根据CHEST杂志十月份的一篇报道,气管支气管成形术可以稳定中央气道并缓解气管支气管软化症(TBM)患者的症状。
“TBM是一种诊断标准不明的疾病,它可以导致广泛的各种各样的肺部症状,包括不明原因的呼吸衰竭和比肺气肿预期症状更严重的表现。” 来自马萨诸塞州,波士顿,哈佛大学医学院,贝斯以色列女执事医疗中心的阿明•恩斯特医生告诉路透社记者。
恩斯特医生及其同事们评价了外科气管支气管成形术在改善35例严重症状性TBM患者症状、生活质量、肺功能和运动能力等方面的效果。
根据对临时放置的气道支架的症状反应来确定患者是否行手术治疗。移除支架之后所进行的手术操作的目的是稳定胸内气管和主支气管的膜壁。
该团队报道,手术后所有患者在进行改良St. George呼吸问卷、基准呼吸困难指数/过渡呼吸困难指数、美国胸科学会呼吸困难评分和Karnofsky绩效评分测试时都呈现出改善表现。
两名因TBM继发呼吸衰竭而需要进行机械通气的患者在支架放置后可以脱离辅助通气,而且都在手术后表现出主观和客观的改善。
15例患者(占43%)发生了手术并发症,包括手术后需要机械通气超过24小时 (7例)、肺炎或支气管炎(4例)、皮下气肿(4例)、心房颤动(3例)、血胸(1例)、横断性脊髓炎(1例),以及死亡两例(5.7%)。
该报告指出,患者住院天数为3 〜 90天,中位数为8天。
研究人员推断,“尽管我们的研究存在局限性,但我们认为结果是令人信服的,我们建议严重的弥漫的症状性TBM患者应到有经验的医学中心进行中央气道稳定性的评价。”
恩斯特医生强调,“目前患者应该在一个有处理TBM经验的医学中心进行所有的评价和干预治疗。”
恩斯特博士补充说,“我们对所有的患者都进行了登记,并出现一年好过一年的长期评估结果”
Chest 2008;134:801-807.
2008-11-22 21:30
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