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【技术产业】癌症治疗中理想的纳米粒子——冲浪板

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http://www.sciencedaily.com/releases/2009/11/091109142123.htm

Ideal Nanoparticle Cancer Therapies Surf the Bloodstream

ScienceDaily (Nov. 15, 2009) — Eric Shaqfeh studies blood at Stanford University, using computer models that simulate how the fluid and the cells it contains move around. On November 11 at a meeting of the scientific society AVS, he will present his latest unpublished findings from two studies. One shows how components in blood line up to prepare for healing; the other demonstrates the best shape to use for man-made nanoparticles that target cancers -- a surfboard.

The different components that move through our blood stream are not evenly distributed. For years, scientists have known that platelets -- which help blood to clot -- stay close to the walls of blood vessels as they circulate.

"When somebody cuts himself, the fact that the platelets are sitting seven times more frequently at the edges of the little blood vessels is critical," says Shaqfeh.

His models suggest that when a new platelet is made, it takes longer than expected to migrate to and line up at the edge -- as much as ten or fifteen minutes to establish "hemostatis," in which blood cells are properly distributed in the body. The research, funded by the Army, suggests that current techniques for blood transfusions may not be ideal. Freezing platelets, which is common practice, may change their shape and disrupt their movements, and there may be better ways to give transfusions that establish the proper blood arrangement faster, says Shaqfeh.

In related work, Shaqfeh added tiny nanoparticles of various sizes and shapes into his blood models. Such particles are of interest to the cancer researchers, who hope to use nanoparticles to target the walls of blood vessels that feed tumors. Shaqfeh found that surfboard-shaped particles stayed closest to the walls of blood vessels. He will soon be working with another group to test fluorescent surfboard-shaped particles in actual blood vessels to see how they behave.

The talk "The Microfluidics of NonSpherical Colloidal Particles and Vesicles with Application to Blood Additives" is on November 11, 2009.

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2009-11-15 21:45 浏览 : 673 回复 : 2

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2009-11-16 14:05

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Ideal Nanoparticle Cancer Therapies Surf the Bloodstream癌症治疗中理想的纳米粒子——冲浪

Science Daily (Nov. 15, 2009) — Eric Shaqfeh studies blood at Stanford University, using computer models that simulate how the fluid and the cells it contains move around. On November 11 at a meeting of the scientific society AVS, he will present his latest unpublished findings from two studies. One shows how components in blood line up to prepare for healing; the other demonstrates the best shape to use for man-made nanoparticles that target cancers -- a surfboard.
2009年11月15日，科学日报报道：斯坦福大学Eric Shaqfeh利用计算机模型模拟出的液体和细胞在血液试验中含有纳米粒。他将提出从他最近的两项未公布研究结果，在11月11日的科学社会AVS的会议上。其一，显示血液治愈功能的组成部分，再者就是使用人造的纳米粒来治愈癌症-来自冲浪板。

The different components that move through our blood stream are not evenly distributed. For years, scientists have known that platelets -- which help blood to clot -- stay close to the walls of blood vessels as they circulate.
纳米粒子的不同组分通过我们的血液流移动中分布并不均匀。多年来，科学家们已经知道血小板-这有助于血液凝固-贴近血管壁血液在血管中是循环的。
"When somebody cuts himself, the fact that the platelets are sitting seven times more frequently at the edges of the little blood vessels is critical," says Shaqfeh.
Shaqfeh指出：“当有人受伤时，血小板起到血液凝固作用在血管的边缘是平时的7倍，对小血管是至关重要的在危急时刻。”
His models suggest that when a new platelet is made, it takes longer than expected to migrate to and line up at the edge -- as much as ten or fifteen minutes to establish "hemostatis," in which blood cells are properly distributed in the body. The research, funded by the Army, suggests that current techniques for blood transfusions may not be ideal. Freezing platelets, which is common practice, may change their shape and disrupt their movements, and there may be better ways to give transfusions that establish the proper blood arrangement faster, says Shaqfeh.
Shaqfeh创建的模型表明，当制造一个新的血小板，它需要更长的时间到达血管的边缘- 10或15分钟恰当的分布在身体的血细胞起到止血剂的作用。从事这项研究Army建议，在现有技术输血可能不理想。Shaqfeh指出目前普遍的做法是冷冻血小板，这可能会改变它们的形状，并破坏它们的活动，可能有更好的办法，使输血的血液分布更快。
In related work, Shaqfeh added tiny nanoparticles of various sizes and shapes into his blood models. Such particles are of interest to the cancer researchers, who hope to use nanoparticles to target the walls of blood vessels that feed tumors. Shaqfeh found that surfboard-shaped particles stayed closest to the walls of blood vessels. He will soon be working with another group to test fluorescent surfboard-shaped particles in actual blood vessels to see how they behave.
Shaqfeh他的血模型相关工作中，加入了各种尺寸和形状的微小粒子是癌症研究人员所感兴趣的做法，他们希望利用纳米粒子作用的目标血管壁来治疗肿瘤。Shaqfeh还发现冲浪板形状的粒子留最接近于血液中的血管壁。他不久将与另一组测试荧光冲浪板形血管颗粒，看看他们如何在血液中起作用.
The talk "The Microfluidics of NonSpherical Colloidal Particles and Vesicles with Application to Blood Additives" is on November 11, 2009.
这项研究讨论胶体颗粒球形囊泡微流体在血液添加剂如何应用在2009年11月11日。

译文总结如下：
2009年11月15日，科学日报报道：斯坦福大学Eric Shaqfeh利用计算机模型模拟出的液体和细胞在血液试验中含有纳米粒。他将提出从他最近的两项未公布研究结果，在11月11日的科学社会AVS的会议上。其一，显示血液治愈功能的组成部分，再者就是使用人造的纳米粒来治愈癌症-来自冲浪板。
纳米粒子的不同组分通过我们的血液流移动中分布并不均匀。多年来，科学家们已经知道血小板-这有助于血液凝固-贴近血管壁血液在血管中是循环的。Shaqfeh指出：“当有人受伤时，血小板起到血液凝固作用在血管的边缘是平时的7倍，对小血管是至关重要的在危急时刻。Shaqfeh创建的模型表明，当制造一个新的血小板时，它需要更长的时间到达血管的边缘- 10或15分钟恰当的分布在身体的血细胞起到止血剂的作用。从事这项研究Army建议，在现有技术输血可能不理想。
Shaqfeh指出目前普遍的做法是冷冻血小板，这可能会改变它们的形状，并破坏它们的活动，可能有更好的办法，使输血的血液分布更快。Shaqfeh他的血模型相关工作中，加入了各种尺寸和形状的微小粒子是癌症研究人员所感兴趣的做法，他们希望利用纳米粒子作用的目标血管壁来治疗肿瘤。Shaqfeh还发现冲浪板形状的粒子留最接近于血液中的血管壁。他不久将与另一组测试荧光冲浪板形血管颗粒，看看他们如何在血液中起作用.这项研究讨论胶体颗粒球形囊泡微流体在血液添加剂如何应用在2009年11月11日。

2009-11-16 15:43

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