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【科普】染发剂和吸烟增加肝脏疾病的风险

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et2005

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Hair Dye and Smoking Linked to Progressive Liver Disease
ScienceDaily (Mar. 23, 2010) — Hair dye and smoking both increase the risk of progressive liver disease, suggests research involving around 5000 people published in the journal Gut.
Primary biliary cirrhosis (PBC), which is an early form of liver cirrhosis, is a long term progressive autoimmune disease, in which environmental factors are thought to play a part.
It causes the liver's plumbing system of bile ducts to become inflamed, scarred, and blocked, leading to extensive tissue damage and irreversible, and ultimately fatal, liver cirrhosis.
The authors base their findings on two series of patients, one of which included 318 out of 381 new cases of PBC arising between 1997 and 2003 in the North East of England. The other series included 2258 out of 3217 members of the United Kingdom PBC Foundation, a national support group for people with the condition.
Finally, 2438 out of 3933 people randomly selected from the electoral roll, and matched for age and sex, were used as a comparison group.
All three groups were sent detailed questionnaires on potential environmental and genetic risk factors associated with PBC.
As expected, autoimmune diseases, such as rheumatoid arthritis, thyroid and coeliac diseases were all more common among those with PBC. And those with a family history of autoimmune disease were more likely to have PBC.
The skin condition psoriasis, urinary infections, and shingles also significantly increased the likelihood of a PBC diagnosis.
Compared to those selected from the electoral roll, both series of patients were 63% more likely to have smoked at some point in their lives, and to have started smoking before their diagnosis.
But patients with PBC were less likely to drink alcohol regularly, although this finding was not statistically significant. Previous research has indicated that alcohol is very unlikely to be a causative factor in PBC.
Less than 1% of male respondents used hair dye, whereas half of all the women surveyed did. When this was investigated among women only, those in the PBC support group were 37% more likely to develop PBC than women in the comparison group.
Respondents were not asked how often they dyed their hair, and it is not clear which component of hair dye might be responsible for this finding, say the authors.
But previous research has indicated an association between PBC and chemicals found in cosmetics, particularly octynoic acid, which is used in hair dye and nail polish, they add.
参考文献：Case%u2013control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations. Gut, 2010; 59: 508-512
原文链接：http://www.sciencedaily.com/releases/2010/03/100323212148.htm

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2010-03-24 14:55 浏览 : 1052 回复 : 1

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et2005 编辑于 2010-03-24 15:02

• 八一建军节，读军医、当军人是一种什么体验？

postgraduate007

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ScienceDaily (Mar. 23, 2010) — Hair dye and smoking both increase the risk of progressive liver disease, suggests research involving around 5000 people published in the journal Gut.
科学日报（2010年3月23日） -研究表明，染发剂和吸烟均增加进展性肝脏疾病的风险，研究对象包括5000人被刊登消化杂志上。

Primary biliary cirrhosis (PBC), which is an early form of liver cirrhosis, is a long term progressive autoimmune disease, in which environmental factors are thought to play a part.
原发性胆汁性肝硬化（PBC）的，是肝硬化的早期形式，是一项长期的渐进自身免疫性疾病，在这过程中环境因素被认为是发挥作用的。
It causes the liver's plumbing system of bile ducts to become inflamed, scarred, and blocked, leading to extensive tissue damage and irreversible, and ultimately fatal, liver cirrhosis.
它会导致肝脏的胆管管道系统发炎，损伤，梗阻，导致广泛的组织损伤，产生不可逆转的，甚至严重致死性肝硬化。

The authors base their findings on two series of patients, one of which included 318 out of 381 new cases of PBC arising between 1997 and 2003 in the North East of England. The other series included 2258 out of 3217 members of the United Kingdom PBC Foundation, a national support group for people with the condition.
该作者立足于两个系列的病人，其中一个组病人是英格兰东北部1997年到2003年患381例新PBC中的318例，另一组病人包括英国PBC基金会（有条件的人资助的组织）的3217个成员中的2258个成员。

Finally, 2438 out of 3933 people randomly selected from the electoral roll, and matched for age and sex, were used as a comparison group.
最后，随机选择3933个选民登记册上的人中的2438个人，年龄和性别与实验组相匹配的，用来作为对照组。

All three groups were sent detailed questionnaires on potential environmental and genetic risk factors associated with PBC.
给三组人发放关于环境和遗传危险因素与PBC关系的详细调查问卷。
As expected, autoimmune diseases, such as rheumatoid arthritis, thyroid and coeliac diseases were all more common among those with PBC. And those with a family history of autoimmune disease were more likely to have PBC.
正如所料，自身免疫性疾病如风湿性关节炎，甲状腺和腹腔疾病，都在PBC患者中普遍存在。在有自身免疫性疾病家族史的人中患PBC可能性更大。
The skin condition psoriasis, urinary infections, and shingles also significantly increased the likelihood of a PBC diagnosis.
牛皮癣的皮肤，尿路感染和带状疱疹也大大增加了PBC患病的可能。
Compared to those selected from the electoral roll, both series of patients were 63% more likely to have smoked at some point in their lives, and to have started smoking before their diagnosis.
与对照组相比，试验组的病人有超过63%的人在生活中的某一阶段有吸烟史，并且在他诊断之前开始吸烟。
But patients with PBC were less likely to drink alcohol regularly, although this finding was not statistically significant. Previous research has indicated that alcohol is very unlikely to be a causative factor in PBC.
但PBC患者也不太可能经常喝酒，但这个发现没有统计学意义。先前的研究表明酒精不是患PBC的诱因
Less than 1% of male respondents used hair dye, whereas half of all the women surveyed did. When this was investigated among women only, those in the PBC support group were 37% more likely to develop PBC than women in the comparison group.
少于1%的男性受访者使用染发剂，然而女性中有半数使用染发剂。当仅仅对女性受访者进行调查时，试验组比对照组多37%的可能性患PBC。
Respondents were not asked how often they dyed their hair, and it is not clear which component of hair dye might be responsible for this finding, say the authors.
But previous research has indicated an association between PBC and chemicals found in cosmetics, particularly octynoic acid, which is used in hair dye and nail polish, they add.
受试者没有被问到多久染一次发，也不清楚染发剂中的那种组成成分会产生这种影响，作者说。
但先前的研究表明在化妆品中的化学物质与PBC有关，特别是octynoic酸，它经常被用到染发剂和指甲油中，他们补充说。

编译
科学日报（2010年3月23日） -研究表明，染发剂和吸烟均增加进展性肝脏疾病的风险，研究对象包括5000人被刊登消化杂志上。原发性胆汁性肝硬化的，是肝硬化的早期形式，是一项长期的渐进自身免疫性疾病，在这过程中环境因素被认为是发挥作用的。它会导致肝脏的胆管管道系统发炎，损伤，梗阻，导致广泛的组织损伤，产生不可逆转的，甚至严重致死性肝硬化。
该作者立足于两个组的病人，其中一个组病人是英格兰东北部1997年到2003年患381例新PBC中的318例，另一组病人包括英国PBC基金会（有条件的人资助的组织）的3217个成员中的2258个成员。最后，随机选择3933个选民登记册上的人中的2438个人，年龄和性别与实验组相匹配的，用来作为对照组。给三组人发放关于环境和遗传危险因素与原发性胆汁性肝硬化关系的详细调查问卷。正如所料，自身免疫性疾病如风湿性关节炎，甲状腺和腹腔疾病，都在原发性胆汁性肝硬化患者中普遍存在。在有自身免疫性疾病家族史的人中患原发性胆汁性肝硬化可能性更大。牛皮癣的皮肤，尿路感染和带状疱疹也大大增加了原发性胆汁性肝硬化患病的可能。与对照组相比，试验组的病人有超过63%的人在生活中的某一阶段有吸烟史，并且在他诊断之前开始吸烟。但原发性胆汁性肝硬化患者也不太可能经常喝酒，但这个发现没有统计学意义。先前的研究表明酒精不是患原发性胆汁性肝硬化的诱因少于1%的男性受访者使用染发剂，然而女性中有半数使用染发剂。当仅仅对女性受访者进行调查时，试验组比对照组多37%的可能性患原发性胆汁性肝硬化。受试者没有被问到多久染一次发，也不清楚染发剂中的那种组成成分会产生这种影响，作者说。但先前的研究表明在化妆品中的化学物质与原发性胆汁性肝硬化有关，特别是octynoic酸，它经常被用到染发剂和指甲油中，他们补充说。

2010-03-25 12:19

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postgraduate007 编辑于 2010-03-25 17:25

• 氯喹无法抑制SARS-CoV-2感染人肺细胞

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