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【Science】肿瘤特刊：抗癌40年 [精华]

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tangdl2000

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这个帖子发布于9年零303天前，其中的信息可能已发生改变或有所发展。

另一个相关话题是
【Cell】肿瘤新十大特征
http://news.dxy.cn/bbs/topic/19539307?tpg=1&age=0

>Science | >Science Signaling | >Science Translational Medicine | >Science Express | >Science Classic

[About the cover] Science, 25 March 2011 (Volume 331, Issue 6024)
http://www.sciencemag.org/content/vol331/issue6024/index.dtl?etoc

Editorial

The Challenge of Cancer
Bruce Alberts
http://www.sciencemag.org/cgi/content/summary/331/6024/1491

Introduction to special issue
Celebrating an Anniversary
P. Kiberstis and E. Marshall
http://www.sciencemag.org/cgi/content/full/331/6024/1539-a

Video: Sequencing Cancer Genomes--Targeted Cancer Therapies
Applying DNA sequencing to cancer genomes is providing insights that have allowed researchers to turn some cancers into chronic diseases rather than deadly ones. Still, the ultimate goal is to kill the cancer.
http://www.sciencemag.org/cgi/content/summary/331/6024/1539-b

News（新闻）
Cancer Research and the $90 Billion Metaphor
Eliot Marshall
In the 40 years since President Richard Nixon first declared "War on Cancer," the cancer campaign has changed therapy and saved lives, as demonstrated in this infographic Science has created of indicators for the seven deadliest cancers.
http://www.sciencemag.org/cgi/content/summary/331/6024/1540-a

40 Years of the War on Cancer
Science presents a timeline chronicling notable events in the war on cancer, launched 40 years ago when U.S. President Richard Nixon signed the National Cancer Act.
http://www.sciencemag.org/cgi/content/summary/331/6024/1540-b

Combining Targeted Drugs to Stop Resistant Tumors
Jocelyn Kaiser
Even the most successful targeted therapies lose potency with time. Researchers hope to figure out how tumors escape; they aim to turn months of survival into years.
http://www.sciencemag.org/cgi/content/summary/331/6024/1542

Can Treatment Costs Be Tamed?
David Malakoff
More patients and the rising costs of new cancer treatments spark debate over how much is too much—and who should decide.
http://www.sciencemag.org/cgi/content/summary/331/6024/1545

A Push to Fight Cancer in the Developing World
Martin Enserink
Cancer and other chronic diseases have received little attention from global health advocates. That's beginning to change.
http://www.sciencemag.org/cgi/content/summary/331/6024/1548

Making Her Life an Open Book to Promote Expanded Care
Martin Enserink
Felicia Knaul, a health economist at Harvard Medical School in Boston, is one half of a Mexican-Canadian power couple that aims to end the neglect of cancer as a disease of the poor—and will succeed, if anyone can, say colleagues.
http://www.sciencemag.org/cgi/content/summary/331/6024/1549

Brothers in Arms Against Cancer
Mitch Leslie
Cancer researchers are trying to harness siblings of p53, the famous tumor-blocking protein.
http://www.sciencemag.org/cgi/content/summary/331/6024/1551

Review（综述）
Exploring the Genomes of Cancer Cells: Progress and Promise

肿瘤基因组
Michael R. Stratton
http://www.sciencemag.org/cgi/content/abstract/331/6024/1553

A Perspective on Cancer Cell Metastasis

肿瘤转移
C. L. Chaffer and R. A. Weinberg
http://www.sciencemag.org/cgi/content/abstract/331/6024/1559

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

肿瘤免疫
R. D. Schreiber et al.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1565

Report(研究报告）

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

CD40治疗胰腺癌
G. L. Beatty et al.
CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice and humans by eliciting antitumor immunity.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1612

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2011-03-25 07:29 浏览 : 25342 回复 : 145

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tangdl2000 编辑于 2011-03-25 20:40

• 一个读研期间执医四战四败的医学生内心独白

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tangdl2000

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上述各部分全文如下

肿瘤基因组.pdf(526.58k)

肿瘤免疫.pdf(556.4k)

肿瘤转移.pdf(475.31k)

CD40治疗胰腺癌.pdf(2244.13k)

新闻.pdf(2507.74k)

2011-03-25 07:47

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tangdl2000 编辑于 2011-03-25 21:02

• （原创）重症高渗高血糖综合征的急诊急救？

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背景知识：

1971年美国总统尼克松批准国家癌症法案修正案，发起“对癌症的战争”。截止到现在正好40年。所以作为美国科学会的期刊《science》叫这一期为抗癌40年。

NCI的原文报道如下：

http://dtp.nci.nih.gov/timeline/noflash/milestones/M4_Nixon.htm

National Cancer Act of 1971
In 1970, the American people made clear their desire for a cure for the second-leading cause of death in the United States. President Nixon responded during his January 1971 State of the Union address: "I will also ask for an appropriation of an extra $100 million to launch an intensive campaign to find a cure for cancer, and I will ask later for whatever additional funds can effectively be used. The time has come in America when the same kind of concentrated effort that split the atom and took man to the moon should be turned toward conquering this dread disease. Let us make a total national commitment to achieve this goal."

As part of this national effort, in October 1971, the Army's Fort Detrick, Maryland, biological warfare facility was converted to a cancer research center, eventually becoming the Frederick Cancer Research and Development Center, an internationally recognized center for cancer and AIDS research.

On December 23, 1971, President Nixon followed through on his promise as he signed the National Cancer Act into law, declaring, "I hope in the years ahead we will look back on this action today as the most significant action taken during my Administration."¹

The National Cancer Act (P.L. 92–218), "The War on Cancer," gave the NCI unique autonomy at NIH with special budgetary authority. （给了NIH预算优先权）The Cancer Chemotherapy National Service Center (CCNSC) increased its efforts to acquire new compounds for testing with the awarding of an acquisition and inventory contract responsible for the collection and documentation of test agents.

¹ Surveillance, Epidemiology, and End Results Program. Cancer Facts & the War on Cancer. 2002.

² Haran C. Vince DeVita: the view from the top. Cancer World June–July 2005;38–43.

National Cancer Act of 1971全文如下

http://legislative.cancer.gov/history/phsa/1971

2011-03-25 09:52

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tangdl2000 编辑于 2011-03-25 10:42

• 新型冠状病毒肺炎疫情下的基层医疗卫生发展策略

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1971年上述法案签署是在12月份，按理来说《科学》应该在下半年出这个特刊才合理。但是提前到上半年，可能是在某种程度上是一种舆论造势，对美国国会拨款委员会的抗议。因为今年2011年2月16日国会提出的方案中，在总统2011年预算需求的基础上削减1000亿美元开支，其中政府各部门支出将被削减620亿美元，削减程度大的部门包括美国国立卫生研究院NIH(NCI是最大的2级单位）。

去年7月15日美国众议院通过了总统奥巴马关于在2011年增加NIH 10亿美元科研经费的议案后，27日，美国参议院一开支委员会也通过了该议案。这将使NIH 2011年的预算达到320亿美元，比2010年增加了3.5%。最终议案都要提交给拨款委员会。

2011-03-25 09:52

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tangdl2000 编辑于 2011-03-25 11:01

• 一图解读｜血常规化验单

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