发帖
每发1个新帖
可以获得0.5个丁当奖励
回帖

【讣告】缅怀大师：Jürg Tschopp博士

只看楼主
页码直达：
直达末页

楼主

tangdl2000

丁香园中级站友

1楼

这个帖子发布于9年零251天前，其中的信息可能已发生改变或有所发展。

生命科学领域失去一位大师：Jürg Tschopp博士

（tangdl2000点评）

2011年3月22日Jürg Tschopp博士与家人一起滑雪的时候，心脏病突发去世，享年60岁。他酷爱运动，对于科研有着独到的见解，在科学以及生活中敢于冒险。他的主要研究领域是细胞死亡和炎症的分子机制，是世界上细胞死亡（特别是死亡受体信号通路）和免疫学（特别是炎症小体）研究领域的领军人物之一。《SCIENCE》、《NATURE》、《CELL》、《NATURE IMMUNOLOGY》、《CELL DEATH AND DIFF》相继在上个月和本月发表社论悼念Jürg Tschopp博士。也让我们在丁香园一起缅怀这位大师。

生平简介：
Jürg Tschopp 1979年在贝塞尔大学（University of Basel）拿到生物物理学PhD，然后加入了在Scripps Clinic的Müller-Eberhard小组中(博士后）。1982年成为洛桑大学的副教授，然后用了7年时间于1989年成为正教授。他的研究兴趣在于凋亡和天然免疫方面。自从2003年起，Jürg Tschopp担任洛桑大学生化系的副主任，近几年里Jürg Tschopp被瑞士生化协会授予了Friedrich Miescher奖，瑞士Cloetta基金，免疫学的Novartis Clinical Immunology Prize，癌症研究的San Salvatore奖和欧洲Cell Death Society Prize，他的研究团队主要致力于先天免疫和细胞死亡的机制研究。Jürg
Tschopp 参加并创建了两家生物技术公司。最近5年就在Science，Nature和 Cell 等顶级期刊上发表20余篇文章。截止其意外死亡那一天，Jürg Tschopp博士的论文H指数是105，论文被引用41980次。

名言：
"发现，尤其是重大发现往往只是单纯的幸运"，"一旦你有一个idea就要毫不犹豫大胆的去follow下去"，

代表作：
1. Tschopp J et al. Nature 1982; 298: 534–538.
2. Tschopp J et al. Nature 1986; 322: 831–834.
3. Tschopp J et al. Nature 1989; 337: 272–274.
4. Lowin B et al. Nature 1994; 370: 650–652.
5. Hahne M et al. Science 1996; 274: 1363–1366.
6. Thome M et al. Nature 1997; 386: 517–521.
7. Irmler M et al. Nature 1997; 388: 190–195.
8. Holler N et al. Nat Immunol 2000; 1: 489–495.
9. Micheau O et al. Cell 2003; 114: 181–190.
10. Tinel A, Tschopp J. Science 2004; 304: 843–846.
11. Janssens S et al. Cell 2005; 123: 1079–1092.
12. Martinon F et al. Nature 2006; 440: 237–241.
13. Muruve DA et al. Nature 2008; 452: 103–107.
14. Dostert C et al. Science 2008; 320: 674–677.
15. Zhou R et al. Nature 2011; 469: 221–225.

最近的文章
Schroder, K., Tschopp, J. (2010). The inflammasomes. Cell 140, 821-832. PubMed
Schroder, K., Zhou, R., Tschopp, J. (2010). The NLRP3 inflammasome: a sensor for metabolic danger? Science 327, 296-300. PubMed
Zhou, R., Tardivel, A., Thorens, B., Choi, I., Tschopp, J. (2010). Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136-140. PubMed
Guarda, G., Dostert, C., Staehli, F., Cabalzar, K., Castillo, R., Tardivel, A., Schneider, P., Tschopp, J. (2009). T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460, 269-273.
PubMedRebsamen, M., Heinz, L.X., Meylan, E., Michallet, M.C., Schroder, K., Hofmann, K., Vazquez, J., Benedict, C.A., Tschopp, J. (2009). DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 10, 916-922. PubMed
Rebsamen, M., Meylan, E., Curran J., Tschopp, J. (2008b). The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. Cell Death Differ. 15, 1804-11. PubMed
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B., Tschopp, J. (2008c). Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674-7. PubMed
Dostert, C., Meylan, E., Tschopp, J. (2008a). Intracellular pattern-recognition receptors. Adv. Drug Deliv. Rev. 60, 830-40.
PubMedCuenin, S., Tinel, A., Janssens, S., Tschopp, J. (2008a). p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress. Oncogene 27, 387-96.
PubMedMuruve, D.A., Petrilli, V., Zaiss, A.K., White, L.R., Clark, S.A, Ross, J., Parks, R.A., Tschopp, J. (2008). The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature, 452, 103-107.
PubMedDostert, C., Petrilli, V., Van Bruggen, R., Steele, C., Mossman, B.T., Tschopp, J. (2008). Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674-677.
PubMedMichallet, M.C., Meylan, E., Ermolaeva, M.A., Vazquez, J., Rebsamen, M., Curran, J., Poeck, H., Bscheider, M., Hartmann, G., Konig, M., et al. (2008). TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 28, 651-661. PubMed
Park, H.H., Logette, E., Raunser, S., Cuenin, S., Walz, T., Tschopp, J., Wu, H. (2007). Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex. Cell 128, 533-546. PubMed
Mayor, A., Martinon, F., De Smedt, T., Petrilli, V., Tschopp, J. (2007). A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat. Immunol. 8, 497-503. PubMed
Papin, S., Cuenin, S., Agostini, L., Martinon, F., Werner, S., Beer, H., Grütter, C., Grütter, M., Tschopp, J. (2007). The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ. 14, 1457-66. PubMed
Pétrilli, V., Dostert, C., Muruve, D., Tschopp, J. (2007a). The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol. 19, 615-22. PubMed
Pétrilli, V., Papin, S., Dostert, C., Mayor, A., Martinon, F. Tschopp, J. (2007b). Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 14, 1583-9. PubMed
Rossi, D.C., Ballenegger, S., Ingold, K., Schneider, P. Tschopp, J. (2007). Kino me siRNA screen of the human Fas pathway. Swiss Medical Weekly. 137, 29S-29S.Schwaller, J., Schneider, P., Mhawech-Fauceglia, P., McKee, T., Myit, S., Matthes, T., Tschopp, J., Donze, O., F. A. Le Gal and B. Huard (2007) Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness. Blood. 109, 331-338. PubMed
Tinel, A., Janssens, S., Lippens, S., Cuenin, S., Logette, E., Jaccard, B., Quadroni, M., Tschopp, J. (2007). Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J. 26, 197-208. PubMed
Martinon, F., Tschopp, J. (2007). Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 14, 10-22. PubMed
Pétrilli, V., Martinon, F. (2007). The inflammasome, autoinflammatory diseases, and gout. Joint Bone Spine. 74, 571-6. PubMed
Dostert, C., Meylan, E., Tschopp, J. (2007). Intracellular pattern-recognition receptors. Adv Drug Deliv Rev. 60, 830-40. PubMed
Kummer, J.A., Micheau, O., Schneider, P., Bovenschen, N., Broekhuizen, R., Quadir, R., Strik, M.C.M., Hack, C. E., Tschopp, J. (2007). Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis. Cell Death and Differentiation. 14, 1486-1496. PubMed
Grutter, C., Briand, C., Capitani, G., Mittl, P.R., Papin, S., Tschopp, J., Grutter, M.G. (2006). Structure of the PRYSPRY-domain: Implications for autoinflammatory diseases. FEBS Lett. 580, 99-106. PubMed
Martinon, F., Petrilli, V., Mayor, A., Tardivel, A., Tschopp, J. (2006). Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241. PubMed
Brissoni, B., Agostini, L., Kropf, M., Martinon, F., Swoboda, V., Lippens, S., Everett, H., Aebi, N., Janssens, S., Meylan, E., Felberbaum-Corti, M., Hirling, H., Gruenberg, J., Tschopp, J., Burns, K. (2006). Intracellular trafficking of interleukin-1 receptor I requires Tollip. Curr. Biol. 16, 2265-2270. PubMed
Didierlaurent, A., Brissoni, B., Velin, D., Aebi, N., Tardivel, A., Kaslin, E., Sirard, J. C., Angelov, G., Tschopp, J., Burns, K. (2006). Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol. Cell. Biol. 26, 735-742. PubMed
Gurcel, L., Abrami, L., Girardin, S., Tschopp, J., van der Goot, F.G. (2006). Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 126, 1135-1145. PubMed
Munding, C., Keller, M., Niklaus, G., Papin, S., Tschopp, J., Werner, S., Beer, H. D. (2006). The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Cell Death Differ. 13, 1938-1949. PubMed
Budd, R.C., Yeh, W.C., Tschopp, J. (2006). cFLIP regulation of lymphocyte activation and development. Nat. Rev. Immunol. 6, 196-204. PubMed
Janssens, S., Tschopp, J. (2006). Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ. 13, 773-784. PubMed
Meylan, E., Tschopp, J. (2006). Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol. Cell 22, 561-569. PubMed
Meylan, E., Tschopp, J., Karin, M. (2006). Intracellular pattern recognition receptors in the host response. Nature 442, 39-44. PubMed
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., Tschopp, J. (2005). Cardif is an adaptor protein in the RIG-l antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167-1172. PubMed
Dohrman, A., Russell, J.Q., Cuenin, S., Fortner, K., Tschopp, J., Budd, R.C. (2005). Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8. J. Immunol. 175, 311-318. PubMed
Dohrman, A., Kataoka, T., Cuenin, S., Russell, J.Q., Tschopp, J., Budd, R.C. (2005). Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation. J. Immunol. 174, 5270-5278. PubMed
Ingold, K., Zumsteg, A., Tardivel, A., Huard, B., Steiner, Q.G., Cachero, T.G., Qiang, F., Gorelik, L., Kalled, S.L., Acha-Orbea, H., Rennert, P.D., Tschopp, J., Schneider, P. (2005). Identification of proteoglycans as the APRIL-specific binding partners. J. Exp. Med. 201, 1375-1383. PubMed
Petrilli, V., Papin, S., Tschopp, J. (2005). The inflammasome. Curr. Biol. 15, R581. PubMed
Martinon, F., Tschopp, J. (2005). NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26, 447-454. PubMed
Janssens, S., Tinel, A., Lippens, S., Tschopp, J. (2005). PIDD mediates NF-kB activation in response to DNA damage. Cell 123,1079-1092. PubMed
Meylan, E., Tschopp, J. (2005). The RIP kinases: crucial integrators of cellular stress. Trends Biochem. Sci. 30, 151-159. PubMed