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【medical-news】羊膜穿刺术比预想的更加安全

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楼主 sunyongjun
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这个帖子发布于14年零86天前，其中的信息可能已发生改变或有所发展。
New study finds amniocentesis safer for pregnant women
Researchers find risk of miscarriage after procedure to be significantly lower than previously reported
Amniocentesis is the most commonly prescribed invasive test performed during pregnancies in the United States. Most women fear them while doctors recommend them based on guidelines from the American College of Obstetricians and Gynecologists. These guidelines stem from past research studies and recommendations by the CDC that were based only on maternal age. Studies that are decades old have suggested that amniocentesis increases the rate of miscarriage by 0.5% or 1 in 200 pregnancies. However, researchers at Mount School of Medicine in conjunction with other institutions involved in the First and Second Trimester Evaluation of Risk for Aneuploidy trial (FASTER trial) have just reported in the November issue of the journal Obstetrics & Gynecology, that pregnancy miscarriage rates after routine midtrimester amniocentesis are significantly lower than rates previously published years ago in the 1970s and 1980s. This study reports that the amniocentesis procedure- related loss risk is approximately 1 in 1,600 pregnancies.

Lead author of the study, "Pregnancy Loss Rates After Midtrimester Amniocentis", Dr. Keith E. Eddleman, MD, Associate Professor of Obstetrics, Gynecology and Reproductive Sciences at Mount Sinai School of Medicine has found that this new study now refutes the typically quoted 0.5% pregnancy loss rate and suggests it may be even lower than 0.1%."Women should be counseled that this older loss rate is archaic and their decision about whether or not to have an amniocentesis should be based on contemporary information about miscarriage rates with newer screening techniques, rather than just relying on general age based risks," said Eddleman. "This new research breakthrough will have a significant effect on how women are counseled about amniocentesis by their doctors and the information they have when deciding about screening for their unborn child."

One of the purposes of the FASTER trial was to calculate the contemporary procedure-related loss rate after midtrimester amniocentesis using patients who were recruited for aneuploidy screening. A total of 35,003 unselected patients were enrolled between 10 3/7 and 13 6/7 weeks of pregnancy and followed until the end of pregnancy. Two groups were derived- those who did or did not undergo amniocentesis. The rate of fetal loss was compared between these groups and the fetal loss rate less than 6 months of gestation was 1.0% and was not statistically different from the control group.

According to researchers, the procedure related loss rate after amniocentesis was 0.06%. Women undergoing amniocentesis were only 1.1 times more likely to have a spontaneous loss. Researchers concluded that the procedure related loss rate after midtrimester amniocentesis performed on patients in a contemporary clinical trial was 0.06%. There was no significant difference in loss rates between those undergoing amniocentesis and those not undergoing amniocentesis.

Aneuploidy is a chromosomal imbalance of one or a few chromosomes above or below the normal human chromosomal number of 46, which may lead a child to have abnormalities including Down Syndrome. Amniocentesis is the standard prenatal detection procedure for aneuploidy. It has been a standard clinical practice to test women using this procedure who are 35 years or older as well as women who are genetically predisposed for certain disorders.
http://www.eurekalert.org/pub_releases/2006-11/tmsh-nsf103006.php
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本人认领该文件,48小时后若未回复,请其他战友自由认领.
2006-12-27 19:44
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本人认领该文件,48小时后若未回复,请其他战友自由认领.
2006-12-29 23:07
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New study finds amniocentesis safer for pregnant women
新的研究发现羊膜穿刺术可以使孕妇更安全
Researchers find risk of miscarriage after procedure to be significantly lower than previously reported
研究者发现在此治疗后流产的危险比以前报道的明显降低
Amniocentesis is the most commonly prescribed invasive test performed during pregnancies in the United States. Most women fear them while doctors recommend them based on guidelines from the American College of Obstetricians and Gynecologists. These guidelines stem from past research studies and recommendations by the CDC that were based only on maternal age. Studies that are decades old have suggested that amniocentesis increases the rate of miscarriage by 0.5% or 1 in 200 pregnancies. However, researchers at Mount School of Medicine in conjunction with other institutions involved in the First and Second Trimester Evaluation of Risk for Aneuploidy trial (FASTER trial) have just reported in the November issue of the journal Obstetrics & Gynecology, that pregnancy miscarriage rates after routine midtrimester amniocentesis are significantly lower than rates previously published years ago in the 1970s and 1980s. This study reports that the amniocentesis procedure- related loss risk is approximately 1 in 1,600 pregnancies.
羊膜穿刺术是美国在妊娠期最常女性都会感到害怕。这些指导方针来自疾病控制中心仅以母亲年龄为依据的来的研究调查和推荐见的一种常规侵入性检查。而当医生根据美国妇产科医师协会的指导方针向妇女们推荐时，大部分。对于几十位较年长的病人的研究却表明羊膜穿刺术增加将怀孕时的流产率增加了0.5%也就是1/200.然而，蒙特医学院与一些其他机构联合参加了妊娠前3个月和中间三个月的危险评估，所用的方法是非整数倍实验（FASTER实验），这些研究者刚刚在妇产科学杂志第11月号上报道在常规的妊娠中期行的羊膜穿刺术相对于以前在20世纪七十年代和八十年代公布可以明显的降低流产率。这项研究还报道了羊膜穿刺术操作中引起的流产率占怀孕总数的大约1/1600.
Lead author of the study, "Pregnancy Loss Rates After Midtrimester Amniocentis", Dr. Keith E. Eddleman, MD, Associate Professor of Obstetrics, Gynecology and Reproductive Sciences at Mount Sinai School of Medicine has found that this new study now refutes the typically quoted 0.5% pregnancy loss rate and suggests it may be even lower than 0.1%."Women should be counseled that this older loss rate is archaic and their decision about whether or not to have an amniocentesis should be based on contemporary information about miscarriage rates with newer screening techniques, rather than just relying on general age based risks," said Eddleman. "This new research breakthrough will have a significant effect on how women are counseled about amniocentesis by their doctors and the information they have when deciding about screening for their unborn child."
这项研究“妊娠中期羊膜穿刺术后的流产率”的领导者Keith E.Eddleman博士是蒙特西奈医学院的产科、妇科和生殖科学副教授，他发现这项新的研究驳倒了以前的认识-流产率为0.5%，而证明流产率应该小于0.1%.他说：“ 我们应该劝告妇女们过去的流产率已经是历史，她们决定是否接受羊膜穿刺术应该决定于新的筛选方法却确定的当代的流产率而不是依赖一般的年龄危险论。”Eddleman说“这项研究将会对当妇女决定筛选她们的胎儿时，她们的医生如何用自己已有的信息给与妇女有关羊膜穿刺术的正确建议。
One of the purposes of the FASTER trial was to calculate the contemporary procedure-related loss rate after midtrimester amniocentesis using patients who were recruited for aneuploidy screening. A total of 35,003 unselected patients were enrolled between 10 3/7 and 13 6/7 weeks of pregnancy and followed until the end of pregnancy. Two groups were derived- those who did or did not undergo amniocentesis. The rate of fetal loss was compared between these groups and the fetal loss rate less than 6 months of gestation was 1.0% and was not statistically different from the control group.
病人们被募集来参加非整数倍的筛选，FASTER测验的目的之一是预测当代妊娠中期羊膜穿刺术相关的流产率。总共有35003位未经筛选的怀孕10周3天到13周6天的病人参加了此项实验，并随访至生产。以接受过或为接受过羊膜穿刺术被分为2组。这两组的流产率比妊娠六个月的流产率低而在统计学上与对照组没有差异。
According to researchers, the procedure related loss rate after amniocentesis was 0.06%. Women undergoing amniocentesis were only 1.1 times more likely to have a spontaneous loss. Researchers concluded that the procedure related loss rate after midtrimester amniocentesis performed on patients in a contemporary clinical trial was 0.06%. There was no significant difference in loss rates between those undergoing amniocentesis and those not undergoing amniocentesis.
研究者发现，羊膜穿刺术后操作相关的流产率为0.06%.接受羊膜穿刺术的妇女发生流产的可能仅为正常的1.1倍。研究者下结论：在当代临床试验中病人在妊娠中期3个月行羊膜穿刺术的操作相关的流产率为0.06%.接受羊膜穿刺术与不接受的流产率没有明显的差异。
Aneuploidy is a chromosomal imbalance of one or a few chromosomes above or below the normal human chromosomal number of 46, which may lead a child to have abnormalities including Down Syndrome. Amniocentesis is the standard prenatal detection procedure for aneuploidy. It has been a standard clinical practice to test women using this procedure who are 35 years or older as well as women who are genetically predisposed for certain disorders.
非整倍性是指个体的染色体不均衡或者或者某些染色体比正常人的染色体数目多或者少包括唐氏综合症。羊膜穿刺术是出生前检测非整倍体的金标准。它已经是一种标准的临床实践，用于检测35岁以上的妇女或者有某种遗传性疾病的妇女。
2006-12-31 00:35
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