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【medical-news】年轻的骨髓增生异常综合征患者死亡率低

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Myelodysplastic Syndromes Less Deadly in the Young

NEW YORK (Reuters Health) Dec 18 - Many patients with myelodysplastic syndromes (MDS), particularly younger patients in lower risk groups, are unlikely to benefit from aggressive treatment such allogeneic stem-cell transplantation, German researchers report in the December 1st issue of the Journal of Clinical Oncology.

Dr. Andrea Kuendgen, and colleagues at Heinrich-Heine-University, Dusseldorf note that MDS mainly affects the elderly. However, the researchers evaluated younger patients to see if any might be suitable candidates for allogeneic stem-cell transplantation. This potentially curative approach carries a high risk of treatment-related complications.

The team examined data on 232 patients less than 50 years old and compared their outcomes with those in 2496 older patients. The younger patients comprised 8.5% of the cohort, a proportion, similar to that seen in other studies.

Survival was significantly longer in the younger group (40 months) than in the older group (23 months). However, this difference was observed only in patients belonging to the low- and intermediate-I-risk categories of the International Prognostic Scoring System. Survival was identical (8 months in both groups) in the intermediate-II and high-risk categories.

The investigators add that there was a particularly large difference in median survival time between the intermediate-I and intermediate-II risk groups (176 months versus 8 months). For low-risk patients, the overall survival rate was more than 86% at 20 years.

Thus the researchers conclude that "aggressive treatment approaches should rarely be recommended to younger MDS patients in the low- and intermediate-I-risk groups."

http://www.medscape.com/viewarticle/549573

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2006-12-20 02:24 浏览 : 983 回复 : 3

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2006-12-20 09:25

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NEW YORK (Reuters Health) Dec 18 - Many patients with myelodysplastic syndromes (MDS), particularly younger patients in lower risk groups, are unlikely to benefit from aggressive treatment such allogeneic stem-cell transplantation, German researchers report in the December 1st issue of the Journal of Clinical Oncology.
纽约（路透社）12月18日-，德国的研究人员在临床肿瘤杂志12月1日版上报道，许多骨髓增生异常综合征(MDS)患者，特别是低风险的年轻患者，不大可能从干细胞异体移植等强力治疗中获益。
Dr. Andrea Kuendgen, and colleagues at Heinrich-Heine-University, Dusseldorf note that MDS mainly affects the elderly. However, the researchers evaluated younger patients to see if any might be suitable candidates for allogeneic stem-cell transplantation. This potentially curative approach carries a high risk of treatment-related complications.
德国杜塞尔多夫海涅大学Andrea Kuendgen博士及其同事注意到，MDS主要侵犯老年人。不过研究人员对年轻患者进行评估，看是否任何人都适合干细胞异体移植。这种有治愈可能的措施带来了很高的与治疗相关的合并症风险。
The team examined data on 232 patients less than 50 years old and compared their outcomes with those in 2496 older patients. The younger patients comprised 8.5% of the cohort, a proportion, similar to that seen in other studies.
研究小组对232名小于50岁的患者进行了研究，并与2496例年老患者进行比较。年轻患者占8.5%，比例与其他研究相类似。
Survival was significantly longer in the younger group (40 months) than in the older group (23 months). However, this difference was observed only in patients belonging to the low- and intermediate-I-risk categories of the International Prognostic Scoring System. Survival was identical (8 months in both groups) in the intermediate-II and high-risk categories.
生存期年轻患者为40个月，年老患者为23个月，年轻患者明显延长。不过，这种差异仅在国际预后评分系统属于低中I风险的患者中看到。在中II和更高风险类别中，生存期相同，二组都为8个月。
The investigators add that there was a particularly large difference in median survival time between the intermediate-I and intermediate-II risk groups (176 months versus 8 months). For low-risk patients, the overall survival rate was more than 86% at 20 years.
研究人员补充道，在中I和中II风险组之间，中位生存期有特别大的差异，达到176个月对8个月。对于低风险患者，20年的总的生存率超过86%。
Thus the researchers conclude that "aggressive treatment approaches should rarely be recommended to younger MDS patients in the low- and intermediate-I-risk groups."
因此研究人员总结道：“强力治疗措施应该很少被推荐到低中I风险的年轻MDS患者。”

2006-12-20 21:28

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xujianhua50 编辑于 2006-12-20 21:36

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纽约（路透社）12月18日报道，德国的研究人员在12月1日版的临床肿瘤杂志上报道，许多骨髓增生异常综合征(MDS)患者，特别是低风险的年轻患者，很少能从干细胞异体移植等强力治疗中获益。
德国杜塞尔多夫海涅大学Andrea Kuendgen博士及其同事注意到，MDS主要侵犯老年人。不过研究人员对年轻患者进行评估，看是否适合干细胞异体移植。但是这种有治愈可能的措施却带来了很大的合并症风险。
研究小组对232名小于50岁的患者进行了研究，并与2496例年老患者进行比较。年轻患者占8.5%，比例与其他研究相类似。
生存期年轻患者为40个月，年老患者为23个月，年轻患者明显延长。不过，这种差异仅在国际预后评分系统属于低、中I风险的患者中看到。在中II和更高风险类别中，二组生存期相同，都为8个月。
研究人员补充道，在中I和中II风险组之间，中位生存期差异特别大，达到176个月对8个月。对于低风险患者，20年的总的生存率超过86%。
研究人员总结道：“强力治疗措施应该很少被推荐到低、中I风险的年轻MDS患者。”

2006-12-20 21:39

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