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【medical-news】严重泌尿系感染的基因学背景

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Genetic Background To Severe Urinary Tract Infections
Science Daily — If you sit on cold boulders or forget to wear your woollen underwear, you can develop a urinary tract infection, or so the story goes. It turns out though, that these diseases are more complicated than this, and in some cases they have a genetic background. Scientists at Lund University in Sweden have found a gene that appears to lie behind many of the most severe urinary tract infections.
It is well known that certain people have a tendency to develop urinary tract infections again and again. These infections often start in childhood. In serious cases they can lead to infections of the renal pelvis, which ultimately can damage the kidneys so severely that the patient will need dialysis or a kidney transplant.

Doctors have long been hoping for a method for early detection of the small group of people who are in the risk zone for renal pelvis infections. If they could single them out early, it would be unnecessary to subject all children who get a urinary tract infection to a thorough and sometimes unpleasant examination. Instead, such examinations and any preventative treatment could be reserved for those who really need it.

"Many research teams have long been looking for a genetic background to the disease. We have found a gene that could be used as a risk marker and a method for singling out the susceptible group," says researcher Ann-Charlotte Lundstedt and Professor Catharina Svanborg.

The gene in question produces a protein that is involved in the immune defence system. It regulates the migration of white blood corpuscles to the kidneys and their work with neutralizing infectious bacteria. The Lund team has previously shown that the gene protects against renal pelvis inflammation in animal experiments. Now, in studies of children and adults with recurrent renal pelvis infections, they have also shown that mutations of this very gene are much more common in kidney patients than in healthy control individuals.

"We also saw that even patients without genetic changes have low levels of this protein. Therefore, a combination of a genetic examinations and a protein measurement could be a good way to find those who are most clearly in the risk zone," says Catharina Svanborg.

The study is published on September 5 in the online, open-access journal PLoS One.

Citation: Lundstedt A-C, McCarthy S, Gustafsson MCU, Godaly G, Jodal U, et al (2007) A Genetic Basis of Susceptibility to Acute Pyelonephritis. PLoS ONE 2(9): e825. doi:10.1371/journal.pone.0000825

http://www.sciencedaily.com/releases/2007/09/070904214408.htm

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2007-09-10 18:44 浏览 : 872 回复 : 2

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2007-09-10 19:53

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Genetic Background To Severe Urinary Tract Infections
泌尿系统感染的遗传背景
Science Daily — If you sit on cold boulders or forget to wear your woollen underwear, you can develop a urinary tract infection, or so the story goes. It turns out though, that these diseases are more complicated than this, and in some cases they have a genetic background. Scientists at Lund University in Sweden have found a gene that appears to lie behind many of the most severe urinary tract infections.
科学日报－如果你坐在冰冷的石头上或者忘了穿羊绒内衣，你可能会患有泌尿系统感染或者发生诸如此类的事情。这些疾病是非常复杂的，在某些情况下存在遗传背景。瑞典Lund大学的科学家们已经发现了一种基因，这种基因是很多泌尿系统感染的发生原因。
It is well known that certain people have a tendency to develop urinary tract infections again and again. These infections often start in childhood. In serious cases they can lead to infections of the renal pelvis, which ultimately can damage the kidneys so severely that the patient will need dialysis or a kidney transplant.
我们知道一些人有反复发生泌尿系统感染的趋向。这种感染常开始于儿童时期。一些严重的情况可能引起肾盂感染，最终引起严重的肾脏损伤，患者需要进行透析或者肾脏移植。
Doctors have long been hoping for a method for early detection of the small group of people who are in the risk zone for renal pelvis infections. If they could single them out early, it would be unnecessary to subject all children who get a urinary tract infection to a thorough and sometimes unpleasant examination. Instead, such examinations and any preventative treatment could be reserved for those who really need it.
在肾盂感染高风险发病区的人群中，医生们长期寻找一种早期检测的方法。如果能早期诊断出这些患者，那么所有患泌尿系统感染的孩子们就不必要进行那样不愉快的检查了。而类似的检查和任何预防性治疗可以提供给真正需要的人。
"Many research teams have long been looking for a genetic background to the disease. We have found a gene that could be used as a risk marker and a method for singling out the susceptible group," says researcher Ann-Charlotte Lundstedt and Professor Catharina Svanborg.
“许多研究小组长期致力于研究这种疾病的遗传背景。我们已经发现一种基因，可以作为一种筛选易感人群的方法和风险标记，”研究人员Ann-Charlotte Lundstedt 和 Professor Catharina Svanborg说。
The gene in question produces a protein that is involved in the immune defence system. It regulates the migration of white blood corpuscles to the kidneys and their work with neutralizing infectious bacteria. The Lund team has previously shown that the gene protects against renal pelvis inflammation in animal experiments. Now, in studies of children and adults with recurrent renal pelvis infections, they have also shown that mutations of this very gene are much more common in kidney patients than in healthy control individuals.
谈及的这个基因产生的一种蛋白质，这种蛋白质和免疫防御系统有关。这种蛋白调节着白血球迁移至肾脏，发挥着中和入侵的细菌的作用。Lund小组以前动物实验发现这个基因对肾盂有保护作用，抑制肾盂炎症。现在，他们研究复发肾盂感染的儿童和成年患者，也发现和健康的对照组相比，患者发病就是那个基因突变引起的。"We also saw that even patients without genetic changes have low levels of this protein. Therefore, a combination of a genetic examinations and a protein measurement could be a good way to find those who are most clearly in the risk zone," says Catharina Svanborg.
“我们也发现了甚至是没有遗传改变的患者这个蛋白也有低水平的表达。为此，进行遗传的检查和蛋白检测是一个对高风险发病区人们的更早期的检测方法，”Catharina Svanborg说。The study is published on September 5 in the online, open-access journal PLoS One.
本文发表于9月5日Citation: Lundstedt A-C, McCarthy S, Gustafsson MCU, Godaly G, Jodal U, et al (2007) A Genetic Basis of Susceptibility to Acute Pyelonephritis. PLoS ONE 2(9): e825. doi:10.1371/journal.pone.0000825

编译：
泌尿系统感染的遗传背景
科学日报－如果你坐在冰冷的石头上或者忘了穿羊绒内衣，你可能会患有泌尿系统感染或者发生诸如此类的事情。这些疾病是非常复杂的，在某些情况下存在遗传背景。瑞典Lund大学的科学家们已经发现了一种基因，这种基因是很多泌尿系统感染的发生原因。
我们知道一些人有反复发生泌尿系统感染的趋向。这种感染常开始于儿童时期。一些严重的情况可能引起肾盂感染，最终引起严重的肾脏损伤，患者需要进行透析或者肾脏移植。
在肾盂感染高风险发病区的人群中，医生们长期寻找一种早期检测的方法。如果能早期诊断出这些患者，那么所有患泌尿系统感染的孩子们就不必要进行那样不愉快的检查了。而类似的检查和任何预防性治疗可以提供给真正需要的人。
“许多研究小组长期致力于研究这种疾病的遗传背景。我们已经发现一种基因，可以作为一种筛选易感人群的方法和风险标记，”研究人员Ann-Charlotte Lundstedt 和 Professor Catharina Svanborg说。
谈及的这个基因产生的一种蛋白质，这种蛋白质和免疫防御系统有关。这种蛋白调节着白血球迁移至肾脏，发挥着中和入侵的细菌的作用。Lund小组以前动物实验发现这个基因对肾盂有保护作用，抑制肾盂炎症。现在，他们研究复发肾盂感染的儿童和成年患者，也发现和健康的对照组相比，患者发病就是那个基因突变引起的。
“我们也发现了甚至是没有遗传改变的患者这个蛋白也有低水平的表达。为此，进行遗传的检查和蛋白检测是一个对高风险发病区人们的更早期的检测方法，”Catharina Svanborg说。
本文发表于9月5日

新手上路，请大家多多指正！！！

2007-09-10 21:05

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飞天猫12 编辑于 2007-09-10 21:10

• 丁香早知道 - 12.6 | 没考研的“差生”同学年薪百万，而我还为生存挣扎

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